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公开(公告)号：WO2015154078A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/024523
申请日：2015-04-06
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： DESAI, Rajiv , JOSHI, Neel Satish , MOONEY, David J. , KOSHY, Sandeep T. , STAFFORD, Alexander G.
CPC classification number: A61L27/52 , A61L27/20 , A61L27/222 , A61L27/26 , A61L27/3886 , A61L27/54 , A61L2300/22 , A61L2300/23 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61L2400/06 , A61L2400/18 , C07D237/26 , C07K14/78 , C08B37/0084 , C08L5/04 , C08L89/00
Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.
Abstract translation: 本公开提供了点击交联的水凝胶和使用方法。
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2.发明申请AMPHIPHILIC DEGRADABLE POLYMERS FOR IMMOBILIZATION AND SUSTAINED DELIVERY OF BIOMOLECULES 审中-公开用于固定和持续分送生物分子的聚合可降解聚合物
公开(公告)号：WO2015130877A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/017640
申请日：2015-02-26
Applicant: UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
Inventor： SONG, Jie , ZHANG, Jing
CPC classification number: A61L27/18 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/414 , C08G63/664 , C08G63/823 , C08G2230/00 , C08L67/04
Abstract: The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. An amphiphilic biodegradable polymer platform is disclosed herein for the stable encapsulation and sustained release of biomolecules, such as SIP.
Abstract translation: 本发明提供了一种通过使用作为有效递送载体的新型两亲性聚合物来控制传递生物分子（例如脂质和蛋白质）的新方法。 这些独特的两亲性聚合物可以用作控制递送载体或组织工程支架，其中可以实现亲脂性或两亲生物活性分子的递送。 本文公开了两亲生物可降解聚合物平台，用于稳定包封和持续释放生物分子，例如SIP。
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3.发明申请COMPOSITIONS AND METHODS FOR THE TREATMENT OF BONE VOIDS AND OPEN FRACTURES 审中-公开用于治疗骨质疏松和开放性骨折的组合物和方法
公开(公告)号：WO2014020610A1
公开(公告)日：2014-02-06
申请号：PCT/IL2013/050657
申请日：2013-08-01
Applicant: POLYPID LTD.
Inventor： EMANUEL, Noam
CPC classification number: A61L27/54 , A61K31/65 , A61L27/12 , A61L27/34 , A61L27/3608 , A61L2300/22 , A61L2300/406 , A61L2430/02 , C08L67/04
Abstract: The present invention relates to compositions, methods and medical devices for the treatment of bone voids and bone defects. The methods of the invention comprise the step of applying to a bone void or bone defect site a composition comprising a matrix which provides local prolonged release of at least one antibiotic agent at the bone void site.
Abstract translation: 本发明涉及用于治疗骨空隙和骨缺损的组合物，方法和医疗装置。 本发明的方法包括向骨空隙或骨缺损部位施加包含基质的组合物的步骤，所述基质在骨空隙部位提供局部延长的至少一种抗生素的释放。
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公开(公告)号：WO2013181529A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/043607
申请日：2013-05-31
Applicant: BAYLOR COLLEGE OF MEDICINE
Inventor： MANSOURI, Mohammad, David , DAROUICHE, Rabih, O.
CPC classification number: A61L29/16 , A61L27/28 , A61L27/54 , A61L29/08 , A61L31/08 , A61L31/16 , A61L2300/22 , A61L2300/404
Abstract: The present invention includes lipoic acid and derivatives thereof useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The present invention further includes compositions and methods useful for coating medical devices. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on the surface of a medical device or subject's body.
Abstract translation: 本发明包括硫辛酸及其衍生物，其用于从医疗装置或受试者的身体的表面除去微生物和/或生物膜嵌入的微生物。 本发明还包括可用于涂覆医疗装置的组合物和方法。 本发明还包括可用于预防或减少微生物和/或生物膜嵌入的微生物在医疗装置或受试者身体的表面上的生长或增殖的组合物和方法。
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5.发明申请GENE DELIVERY STENT USING A TITANIUM OXIDE THIN FILM COATING, AND METHOD FOR FABRICATING SAME 审中-公开使用氧化钛薄膜涂层的基因递送支架及其制造方法
公开(公告)号：WO2012081850A3
公开(公告)日：2012-08-16
申请号：PCT/KR2011009298
申请日：2011-12-02
Applicant: CHONNAM NAT UNIVERSITY HOSPITAL , KWON JIN SOOK , AHN YOUNG KEUN , JEONG MYUNG HO , SONG SUN JUNG , CHO DONG LYUN
Inventor： KWON JIN SOOK , AHN YOUNG KEUN , JEONG MYUNG HO , SONG SUN JUNG , CHO DONG LYUN
CPC classification number: A61L31/16 , A61F2/82 , A61F2240/001 , A61F2250/0067 , A61F2310/00407 , A61L27/54 , A61L31/022 , A61L31/088 , A61L2300/22 , A61L2300/236 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/41 , A61L2300/416 , A61L2300/418 , A61L2300/45 , A61L2300/802 , A61L2400/18 , A61L2420/08
Abstract: The present invention relates to a gene delivery stent using a titanium oxide thin film coating, and to a method for fabricating the gene delivery stent. The gene delivery stent is loaded with medication having anti-inflammatory and antithrombotic functions, and delivers a gene for inhibiting the growth of vascular smooth muscle cells. Accordingly, late thrombosis or metal allergy can be reduced, and vascular restenosis in the stent region can be prevented, thereby increasing the treatment effects of the gene delivery stent when inserted in a blood vessel.
Abstract translation: 本发明涉及使用氧化钛薄膜涂层的基因递送支架，以及制造基因递送支架的方法。 基因递送支架装载有具有抗炎和抗血栓形成功能的药物，并递送用于抑制血管平滑肌细胞生长的基因。 因此，可以减少晚期血栓形成或金属变态反应，并且可以防止支架区域中的血管再狭窄，由此增加基因递送支架插入血管时的治疗效果。
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Patent Agency Ranking
公开(公告)号：WO2012081850A2
公开(公告)日：2012-06-21
申请号：PCT/KR2011/009298
申请日：2011-12-02
CPC classification number: A61L31/16 , A61F2/82 , A61F2240/001 , A61F2250/0067 , A61F2310/00407 , A61L27/54 , A61L31/022 , A61L31/088 , A61L2300/22 , A61L2300/236 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/41 , A61L2300/416 , A61L2300/418 , A61L2300/45 , A61L2300/802 , A61L2400/18 , A61L2420/08
Abstract: 본발명은 티타늄 산화물 박막코팅을 이용한 유전자 전달 스텐트 및 그 제조방법에 관한 것으로，상기 본 발명에 따른 스텐트는 항염증 및 항혈전 작용이 있는 약물의 탑재와 동시에 혈관 평활근 세포의 증식을 억제할 수 있는 유전자의 전달을 동시에 가능하게 함으로써 후기 혈전증이나 금속 과민증을 감소시킬 수 있을 뿐만 아니라 스텐트 내 혈관 재협착을 방지할 수 있어 혈관 삽입용 스텐트의치료효과를 증대시킬 수 있는 장점이 있다.
Abstract translation: 本发明涉及使用氧化钛薄膜包衣的基因递送支架，以及制造基因递送支架的方法。 基因递送支架装载有具有抗炎和抗血栓形成功能的药物，并且提供用于抑制血管平滑肌细胞生长的基因。 因此，可以降低晚期血栓形成或金属变态反应，并且可以防止支架区域中的血管再狭窄，从而在插入血管时增加基因递送支架的治疗效果。
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公开(公告)号：WO2011007353A1
公开(公告)日：2011-01-20
申请号：PCT/IL2010/000563
申请日：2010-07-14
Applicant: POLYPID LTD. , EMANUEL, Noam , NEUMAN, Moshe , BARAK, Shlomo
Inventor： EMANUEL, Noam , NEUMAN, Moshe , BARAK, Shlomo
IPC: A61K9/127
CPC classification number: A61K9/1617 , A61K9/1641 , A61K9/1647 , A61K31/65 , A61L24/0015 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/22 , A61L2300/406 , A61L2300/416 , A61L2300/602
Abstract: The present invention provides compositions for extended release of one or more active ingredients, comprising a lipid-saturated matrix formed from a non-biodegradable polymer or a block- co-polymers comprising a non-biodegradable polymer and a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.
Abstract translation: 本发明提供了用于延长释放一种或多种活性成分的组合物，其包含由不可生物降解的聚合物形成的脂质饱和基质或包含不可生物降解的聚合物和可生物降解的聚合物的嵌段共聚物。 本发明还提供了生产基质组合物的方法和使用该基质组合物来提供活性成分在有需要的受试者体内的受控释放的方法。
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公开(公告)号：WO2010042134A1
公开(公告)日：2010-04-15
申请号：PCT/US2008/085386
申请日：2008-12-03
Applicant: ATRIUM MEDICAL CORPORATION , FAUCHER, Keith, M. , TANG, Hui , FERRARO, Joseph , MARTAKOS, Paul , HERWECK, Steve, A. , KARWOSKI, Theodore , CORBELL, Scott, E.
Inventor： FAUCHER, Keith, M. , TANG, Hui , FERRARO, Joseph , MARTAKOS, Paul , HERWECK, Steve, A. , KARWOSKI, Theodore , CORBELL, Scott, E.
CPC classification number: A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
Abstract translation: 描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。 脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。 还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。
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9.发明申请IMPROVED PHARMACEUTICAL-COATED MEDICAL PRODUCTS, THE PRODUCTION THEREOF AND THE USE THEREOF 审中-公开改进的覆盖层的医疗药品，其生产和使用
公开(公告)号：WO2009018816A3
公开(公告)日：2010-01-21
申请号：PCT/DE2008001285
申请日：2008-08-01
Applicant: INVATEC TECHNOLOGY CT GMBH , SCHELLER BRUNO , SPECK ULRICH
Inventor： SCHELLER BRUNO , SPECK ULRICH
CPC classification number: A61M25/1029 , A61L29/08 , A61L29/145 , A61L29/16 , A61L2300/204 , A61L2300/21 , A61L2300/22 , A61L2300/602 , A61L2420/02 , A61L2420/06 , A61M25/0045 , A61M25/10 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , B05D1/26
Abstract: The present invention relates to novel combinations of balloon catheters and active ingredient preparations adhering to the surface of the balloon membrane. The present invention further relates to coating methods for producing said balloon catheters, and to the use thereof for the treatment and prophylaxis of vascular diseases.
Abstract translation: 本发明涉及一种气囊导管的新组合并粘附到活性化合物的球囊膜制品的表面上。 此外，用于制备血管疾病的这些气囊导管及其用于治疗和预防本发明涂层的方法涉及。
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公开(公告)号：WO2009052516A2
公开(公告)日：2009-04-23
申请号：PCT/US2008080540
申请日：2008-10-20
Applicant: MIV THERAPEUTICS INC , LANDY MARK , TSVETKOV ALEKSEY , CHEN MICHAEL N C , MANUS TSUI
Inventor： LANDY MARK , TSVETKOV ALEKSEY , CHEN MICHAEL N C , MANUS TSUI
CPC classification number: A61L31/146 , A61L31/082 , A61L31/16 , A61L2300/22 , A61L2300/452 , A61L2420/02 , B05D1/02 , B05D3/105 , B05D7/52 , B05D2203/30
Abstract: Disclosed herein are medical devices, such as stents, comprising a porous substrate, such as a porous ceramic. Also disclosed herein are methods for impregnating the porous substrate with a composition comprising at least one lipid and at least one pharmaceutically active agent, where the porous substrate is microporous and/or nanoporous.
Abstract translation: 本文公开了包括诸如多孔陶瓷的多孔基底的医疗装置，例如支架。 本文还公开了用包含至少一种脂质和至少一种药物活性剂的组合物浸渍多孔底物的方法，其中多孔底物是微孔和/或纳米多孔的。
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