公开(公告)号：WO0191828A3

公开(公告)日：2002-04-04

申请号：PCT/US0117247

申请日：2001-05-25

Applicant: ABIOMED INC

Inventor： FASCIANO ROBERT W ,  ZARINETCHI FARHAD ,  KUNG ROBERT T V ,  BHUNIA SOURAV K

IPC: A61M1/10 ,  A61M1/12

CPC classification number: A61M1/1044 ,  A61M1/1037 ,  A61M1/106 ,  A61M1/1063 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122

Abstract: A biventricular cardiac prosthesis has a flow balance control system to balance blood flow through the left and right sides of the prosthesis to maintain a patient's left atrial pressure within physiologic bounds. The prosthesis can be configured to have flow characteristics so that a signal representative of the difference in hydraulic pumping pressures on the left and right sides of the prosthesis is representative of the difference between left and right atrial pressures of a patient having the prosthesis implanted. This signal can be used as a control signal to drive the prosthesis so that left atrial pressure is approximately equal to right atrial pressure, and within physiologic bounds. A specific prosthesis includes left and right pumping sections, each having a blood pumping chamber and a hydraulic fluid chamber, with a reciprocating hydraulic pump driving systole alternately on the right and left sides. A hydraulic balance chamber is hydraulically coupled to the right hydraulic fluid chamber and an adjustable occluder varies flow resistance through the hydraulic coupling. The occluder can be adjusted based on the control signal to adjustably derate right side blood flow to achieve the desired pressure balance, or the occluder can be adjusted based on fluid communication with sources of pressure in the prosthesis that are representative of right and left atrial pressures.

Abstract translation: 双心室心脏假体具有流量平衡控制系统，以平衡穿过假体左侧和右侧的血流，以将患者的左心房压力维持在生理范围内。 假体可被构造成具有流动特性，使得表示假体左侧和右侧的液压泵送压力的差异的信号代表植入假体的患者的左心房和右心房压力之间的差异。 该信号可用作驱动假体的控制信号，使得左心房压力近似等于右心房压力，并且在生理范围内。 具体的假体包括左右泵送部分，每个部分具有血液泵腔和液压腔，其中往复式液压泵在右侧和左侧交替地驱动收缩器。 液压平衡室液压耦合到右液压流体室，可调节的封闭器通过液压联轴器改变流动阻力。 可以基于控制信号来调节闭塞器，以可调节地降低右侧血流量以实现所需的压力平衡，或者可以基于与代表右心房和左心房压力的假体中的压力源的流体连通来调节闭塞器 。

公开(公告)号：WO2005002645A1

公开(公告)日：2005-01-13

申请号：PCT/IL2004/000500

申请日：2004-06-10

Applicant: DYNAMICOR LTD. ,  LAVEE, Jacob ,  SHAHAR, Menashe ,  BEN SHALOM, Zvi

Inventor： LAVEE, Jacob ,  SHAHAR, Menashe ,  BEN SHALOM, Zvi

IPC: A61M1/10

CPC classification number: A61H9/0078 ,  A61H9/00 ,  A61M1/106 ,  A61M1/1063 ,  A61M1/1065 ,  A61M1/1068 ,  A61M1/1086 ,  A61M1/12 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2210/12 ,  A61M2210/125 ,  A61M2230/04 ,  A61M2230/005

Abstract: A hydraulic system and method for supporting a body organ, the system comprising a closed loop liquid-tight tubing fitted with a pressure generator (20) for propelling a liquid through the system, an organ engaging member (40) connected to a pressure chamber (30) via a discharge valve (34) for controlled discharge of liquid into the organ inflatable pressure member. The organ engaging member comprises an inflatable pressure member (46) suited for receiving the organ. There is further provided at least one control valve for selectively controlling liquid flow through the system and a controller (c) for selectively controlling the discharge valve and the at least one control valve.The system may be used as cardiac assist device or for massaging a limb to stimulate blood flow therethrough.

Abstract translation: 一种用于支撑身体器官的液压系统和方法，所述系统包括装配有用于推动液体通过所述系统的压力发生器（20）的闭环液体密封管，连接到压力室的器官接合构件（40） 30）通过用于将液体控制排放到器官可充气压力构件中的排放阀（34）。 器官接合构件包括适于接收器官的可充气压力构件（46）。 还提供了至少一个用于选择性地控制通过系统的液体流量的控制阀和用于选择性地控制排出阀和至少一个控制阀的控制器（c）。该系统可以用作心脏辅助装置或用于按摩 肢体刺激血液流过。

公开(公告)号：WO0224254A2

公开(公告)日：2002-03-28

申请号：PCT/GB0104250

申请日：2001-09-24

Applicant: IMP COLLEGE INNOVATIONS LTD ,  KHAGHANI ASGHAR ,  ANDREWS GEOFFREY THOMAS ,  BOWLES CHRISTOPHER ,  SMITH NIGEL GORDON

Inventor： KHAGHANI ASGHAR ,  ANDREWS GEOFFREY THOMAS ,  BOWLES CHRISTOPHER ,  SMITH NIGEL GORDON

IPC: A61M1/10

CPC classification number: A61M1/107 ,  A61M1/1008 ,  A61M1/1058 ,  A61M1/106 ,  A61M1/1063 ,  A61M1/1067 ,  A61M1/12 ,  A61M2205/0283

Abstract: A blood circulation assistance device (1), for location around a blood conduit (20). The device comprises: an inflatable bladder (10) moveable between a contracted form and an expanded form, for compressing the blood conduit (20) to provide counterpulsation. Pump means (30) in fluid communication with the bladder (10) move the bladder (10) from the contracted form to the expanded form. The pump means (30) comprises a centrifugal impeller (62) rotatable about an axis (61) to effect pumping. The impeller (62) is moveable axially between first and second positions to effect a reversal of the direction of pumping. Control means (50), in communication with the pump means, is capable of monitoring the cardiac cycle of an individual and triggering the pump means (30) to move the bladder (10) to the expanded form at diastole. An outer cuff, surrounds at least a portion of the bladder (10), providing an outer limiting extent to the movement of the bladder (10).

Abstract translation: 一种用于位于血液导管（20）周围的血液循环辅助装置（1）。 该装置包括：可膨胀囊（10），其可在收缩形式和膨胀形式之间移动，用于压缩血管（20）以提供反搏。 与气囊（10）流体连通的泵装置（30）将囊（10）从收缩形式移动到膨胀形式。 泵装置（30）包括可围绕轴线（61）旋转以实现泵送的离心式叶轮（62）。 叶轮（62）可在第一和第二位置之间轴向运动，以实现泵送方向的反转。 与泵装置连通的控制装置（50）能够监测个体的心动周期并且触发泵装置（30）以在舒张期将膀胱（10）移动到扩张形式。 外囊套围绕囊（10）的至少一部分，为膀胱（10）的移动提供外部限制范围。

公开(公告)号：WO1989003696A1

公开(公告)日：1989-05-05

申请号：PCT/GB1988000920

申请日：1988-10-21

Applicant: RESEARCH CORPORATION LIMITED ,  GREENWOOD, Roger, Newton ,  ALDRIDGE, Colin ,  TATTERSALL, James, Erskine ,  BARRETT, Rodney, Valentine

Inventor： RESEARCH CORPORATION LIMITED

IPC: A61M01/30

CPC classification number: A61M1/30 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1063 ,  A61M1/1698 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3604 ,  A61M1/3679 ,  A61M5/1486

Abstract: Blood purification apparatus comprises a dead-end system in which blood from the patient is allowed to flow through one or more purification modules (4), such as a dialyser, a haemofilter, a haemoperfusion column and an oxygenator, into a resiliently walled reservoir (6), which is conveniently a standard blood bag. The direction of flow of the blood is then reversed by exertion of sufficient pressure on the bag (6) to push the blood back through the purification module (4) to the patient's circulation. Thus, since the reservoir is of variable capacity, being of resilient material for example, the capacity of the apparatus remains equal to the volume of extra-corporeal blood.

Abstract translation: 血液净化装置包括死端系统，其中允许来自患者的血液通过一个或多个净化模块（例如透析器，血液滤过器，血液灌注柱和充氧器）流入弹性壁储存器，这是方便的 一个标准血袋。 然后通过在袋上施加足够的压力来逆转血液的流动方向，以将血液通过净化模块推回患者的循环。 因此，由于储存器具有可用容量，例如具有弹性材料，装置的容量保持等于体外血液的体积。

公开(公告)号：WO2014155119A1

公开(公告)日：2014-10-02

申请号：PCT/GB2014/050977

申请日：2014-03-27

Applicant: QUANTA FLUID SOLUTIONS

Inventor： BUCKBERRY, Clive

IPC: A61M1/06 ,  A61M1/10

CPC classification number: A61M1/1048 ,  A61M1/1006 ,  A61M1/1008 ,  A61M1/1037 ,  A61M1/1043 ,  A61M1/106 ,  A61M1/1063 ,  A61M1/1065 ,  A61M1/1086 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M1/3612 ,  A61M1/3639 ,  A61M2205/12 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3344 ,  F04B43/02 ,  F04B49/20

Abstract: A blood pump comprising a cartridge, the cartridge comprising a first recess therein, said first recess having a surface, and a flexible diaphragm closing said first recess, the first recess and the flexible diaphragm defining a first pump chamber, said first pump chamber having an inlet and an outlet wherein the flexible diaphragm of the first pump chamber is movable between a first position, separated in use from the surface of the first recess, in which said first pump chamber has a maximum volume, and a second position, substantially adjacent to the surface of the first recess, in which said first pump chamber has a minimum volume a pump driver arranged to interface with the cartridge, said pump driver operable to move the flexible diaphragm of the first pump chamber in a first direction into said first recess to, in use, pump blood from the chamber and to move the flexible diaphragm of the first pump chamber in a second direction away from the first recess to, in use, draw blood into said first pump chamber, wherein the pump driver controls the movement of the flexible diaphragm of the first pump chamber such that the flexible diaphragm of the first pump chamber moves toward said first position at a first speed and moves toward said second position at a second speed, said second speed being greater than said first speed.

Abstract translation: 一种血泵，包括一个药筒，所述药筒包括其中的第一凹槽，所述第一凹部具有表面，以及封闭所述第一凹槽的柔性膜片，所述第一凹槽和所述柔性膜片限定第一泵室，所述第一泵室具有 入口和出口，其中所述第一泵室的柔性隔膜可在第一位置和第二位置之间移动，所述第一位置在使用中与所述第一泵室具有最大容积的所述第一凹部的表面分开， 所述第一凹部的表面，其中所述第一泵室具有最小体积，泵驱动器被布置成与所述筒相接触，所述泵驱动器可操作以将所述第一泵室的柔性隔膜沿第一方向移动到所述第一凹槽中， 在使用中，从腔室抽取血液并使第一泵室的柔性隔膜沿远离第一凹槽的第二方向移动，在使用中将血液I抽出 在所述第一泵室中，其中所述泵驱动器控制所述第一泵室的所述柔性膜片的运动，使得所述第一泵室的柔性膜片以第一速度朝向所述第一位置移动，并且在第二泵室处移动到所述第二位置 速度，所述第二速度大于所述第一速度。

公开(公告)号：WO2003034893A2

公开(公告)日：2003-05-01

申请号：PCT/US2001/020170

申请日：2001-06-25

Applicant: LTK ENTERPRISES, L.L.C.

Inventor： KORAKIANITIS, Theodosios ,  GRANDIA, Lonn

IPC: A61B

CPC classification number: A61M1/1096 ,  A61M1/1005 ,  A61M1/1037 ,  A61M1/1055 ,  A61M1/1063 ,  A61M1/1081 ,  A61M1/1086 ,  A61M1/1087 ,  A61M1/1098 ,  A61M1/122 ,  A61M2205/33 ,  A61M2205/3303

Abstract: A method of optimizing a mechanical cardiac pumping device includes modeling the circulatory system of the patient who will receive the mechanical cardiac pumping device and identifying an operating condition of the native heart to which the device will respond. The model is used to determine the required blood volume to be ejected from the device and an initial estimate of the power required to be provided to the mechanical cardiac pumping device is provided in order to provide the required ejected blood volume. The resultant ejected blood volume is evaluated with data obtained from the model and the estimate of the power requirement is then updated. The above steps are iteratively performed until the power required to obtain the necessary ejected blood volume is identified. Possible variations of power and pumping rate that allow the mechanical cardiac pumping device to provide the required volume are determined and the variation that best matches the physiological constraints of the patient and minimizes the power required by the mechanical cardiac pumping device is selected. The steps are iteratively performed until the mechanical cardiac pumping device is optimized to respond to each desired operating condition of the native heart.

Abstract translation: 优化机械心脏泵送装置的方法包括建模患者的循环系统，其将接收机械心脏泵送装置并且识别装置将响应的原生心脏的操作状态。 该模型用于确定要从装置喷射的所需血液体积，并且提供要提供给机械心脏泵送装置的功率的初始估计，以便提供所需的喷射血液体积。 用从模型获得的数据评估所得到的排出血液体积，然后更新功率需求的估计。 迭代地执行上述步骤，直到确定获得必要的喷射血液体积所需的功率。 确定允许机械心脏泵送装置提供所需体积的功率和泵送速率的可能变化，并且选择与患者的生理约束最佳匹配并使机械心脏泵送装置所需功率最小化的变化。 重复执行这些步骤，直到机械心脏泵送装置被优化以响应天然心脏的每个期望的操作条件。

公开(公告)号：WO1995007109A1

公开(公告)日：1995-03-16

申请号：PCT/CA1994000492

申请日：1994-09-09

Applicant: OTTAWA HEART INSTITUTE RESEARCH CORPORATION

Inventor： OTTAWA HEART INSTITUTE RESEARCH CORPORATION ,  MUSSIVAND, Tofy

IPC: A61M01/12

CPC classification number: A61M1/1063 ,  A61M1/1037 ,  A61M1/1086 ,  A61M1/1096 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/8243

Abstract: The invention is directed to a unified system (1) for an electrohydraulic ventricular assist device adapted for implantation in the thorax and for cannulation to the blood circulatory system comprising an internal electronic controller (3) for generating an actuating signal actuating means for converting the actuating signal into a back and forth rhythmic displacement of a fluid, a blood pumping chamber (15) having an inflow blood port (19) and an outflow blood port (21) for converting the back and forth displacement of the fluid into a rhythmic unidirectional displacement of blood through the inflow and outflow ports (19, 21), hermetic coupling means (49) for supplying the internal electronic controller (3) with a supply voltage (45), detecting means (9) for generating the actuating signal in response to the status of the blood pumping chamber (15), a volume displacement chamber (VDC) acting as a reservoir for the back and forth rhythmic displacement of a fluid, and a support with a surface curvature compatible with the internal human sagittal and transverse chest wall curvatures for supporting the internal electronic controller (3), the actuating means (11), the blood pumping chamber (15), the hermetic coupling means (49) and the detecting means (9) in a compact structure with the blood pumping chamber (15) arranged with the inflow and outflow ports (19, 21) oriented away from the support and the structure with an overall size that when the unified system (1) is placed within the human thorax with the support surface adjacent the chest wall, the structure does not adversely compress adjacent organs.

Abstract translation: 本发明涉及一种用于电动液压心室辅助装置的统一系统（1），其适用于植入胸腔并用于插入血液循环系统，包括内部电子控制器（3），用于产生致动信号致动装置，用于转换致动 信号进入流体的来回节奏性位移，具有流入血液端口（19）的血液泵腔（15）和用于将流体的前后位移转换成节奏单向位移的流出血液端口（21） 通过流入和流出端口（19,21）的血液，用于向内部电子控制器（3）提供电源电压（45）的气密耦合装置（49），用于响应于 血液泵腔（15）的状态，用作流体的前后节奏位移的储液器的体积位移室（VDC），以及作为 用于支撑内部电子控制器（3），致动装置（11），血液泵腔（15），气密耦合装置（49）和检测装置（49）的内部人矢状矢量和横向胸壁曲率 9）具有紧凑的结构，其中所述血液泵送室（15）布置成使得所述流入口（19,21）远离所述支撑件和所述结构取向，所述总体尺寸使得当所述统一系统（1） 人体胸部与支撑面邻近胸壁，结构不会不利地压迫邻近器官。

公开(公告)号：WO2009121962A1

公开(公告)日：2009-10-08

申请号：PCT/EP2009/054027

申请日：2009-04-03

Applicant: DEUTSCHES ZENTRUM FÜR LUFT- UND RAUMFAHRT E. V. ,  VODERMAYER, Berndhard ,  WAGNER, Harald ,  SCHILLER, Wolfgang ,  SCHMID, Thomas

Inventor： VODERMAYER, Berndhard ,  WAGNER, Harald ,  SCHILLER, Wolfgang ,  SCHMID, Thomas

IPC: A61M1/10

CPC classification number: A61M1/106 ,  A61M1/101 ,  A61M1/1037 ,  A61M1/1063 ,  A61M1/12 ,  A61M1/122

Abstract: Die Erfindung betrifft eine Herzunterstützungsvorrichtung zur pulsatilen Förderung von Blut (12) mit einem ersten (14) und einem zweiten (16) Ventrikel und einer Pumpe (18). Beide Ventrikel (14, 16) weisen jeweils eine Fluidkammer (14a, 16a) und eine blutführende Kammer (14b, 16b) auf, wobei jede Fluidkammer (14a, 16a) durch die Pumpe (18) mit einem Fluid (20) derart befullbar oder entleerbar ist, dass eine Expansion oder eine Kontraktion der Fluidkammer (14a, 16a) erfolgt. Bei der Expansion der Fluidkammer (14a) eines Ventrikels (14) erfolgt eine Kompression der blutführenden Kammer (14b) des selben Ventrikels, wobei zwischen einer Fluidkammer (14a, 16a) und der jeweiligen blutführenden Kammer ( 16a, 16b) eine in Richtung der jeweiligen blutführenden Kammer (14b, 16b) verschiebbare steife Druckplatte (24) angeordnet ist.

Abstract translation: 本发明涉及一种心脏用于具有第一（14）脉动促进血液（12）和第二（16）心室，和泵（18），辅助装置。 两个心室（14，16）各包括一个流体室（14A，16A）和血液 - 运送室（14B，16B），其中每个流体腔室（14A，16A）由泵（18）与流体（20），例如befullbar或 被清空，流体腔室（14A，16A）的该膨胀或收缩来实现。 一旦心室的流体室（14a）的膨胀（14）进行的血液承载腔室的压缩（14b）的同一心室，其中一个流体室（14A，16A）和相应的载血液室之间（16A，16B）中的每个方向中的一个 血液运送室（14B，16B）移动的刚性压力板（24）布置。

公开(公告)号：WO01080927A2

公开(公告)日：2001-11-01

申请号：PCT/US2001/040579

申请日：2001-04-23

IPC: A61M1/10 ,  A61M1/12 ,  A61M1/00

CPC classification number: A61M1/1063 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/122 ,  A61M1/127

Abstract: Systems and methods of supplementing blood flow from the heart of a patient (10) involving superficial, non-invasive procedures. In one general method, a first conduit (20) is directed into the left side of the heart, a second conduit (24) is directed into a superficial vessel (26) and a pump (16) is connected between the first and second conduits (20, 24). The pump (16) is implanted superficially in the patient (10) and a power supply (18) is connected to the pump (16). Blood is then suctioned from the left side of the patient's heart through the first conduit (20) into the pump (16) and expelled from the pump (16) into the second conduit (24) and the superficial vessel (26). A transcutaneous power supply (18) is disclosed in one aspect and includes an external portion with a connection and alignment feature to assure transmission of power.

Abstract translation: 补充来自患者（10）的心脏的血液流动的系统和方法涉及表面的，非侵入性的程序。 在一般的方法中，第一导管（20）被引导到心脏的左侧，第二导管（24）被引导到浅表容器（26）中，并且泵（16）连接在第一和第二导管 （20,24）。 泵（16）表面植入患者（10）中，电源（18）连接到泵（16）。 然后将血液从患者心脏的左侧通过第一导管（20）吸入泵（16）并从泵（16）排出到第二导管（24）和浅表容器（26）中。 在一方面公开了一种经皮电源（18），并且包括具有连接和对准特征的外部部分，以确保功率传递。

公开(公告)号：WO0076288A3

公开(公告)日：2001-05-25

申请号：PCT/AU0000654

申请日：2000-06-09

Applicant: SUNSHINE HEART CO PTY LTD ,  PETERS WILLIAM SUTTLE ,  MARSH PETER CRISPIN LAWRENCE ,  WHITE GEOFFREY HAMILTON ,  MILSOM FREDERICK PAGET ,  HENRICHSEN HANS HANSFORTH ,  UNGER ROLF GUNNAR ,  SULLIVAN COLIN EDWARD

Inventor： PETERS WILLIAM SUTTLE ,  MARSH PETER CRISPIN LAWRENCE ,  WHITE GEOFFREY HAMILTON ,  MILSOM FREDERICK PAGET ,  HENRICHSEN HANS HANSFORTH ,  UNGER ROLF GUNNAR ,  SULLIVAN COLIN EDWARD

IPC: A61M1/12 ,  A61M1/10

CPC classification number: A61M1/1037 ,  A61M1/1051 ,  A61M1/1055 ,  A61M1/106 ,  A61M1/1063 ,  A61M1/1065 ,  A61M1/1067 ,  A61M1/107 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122 ,  A61M2230/04 ,  A61M2230/30

Abstract: A heart assist device (10) adapted for implantation into a patient (99). The device (10) includes an aortic compression means (60) adapted, when actuated, to compress an aorta (15) of a patient (99), a fluid reservoir (74) and a pump means (71) adapted to pump a fluid from the fluid reservoir (74) to the aortic compression means (60) so as to actuate the aortic compression means (60) at least partly in counterpulsation with the patient's heart. The fluid reservoir (74) is adapted to be wholly positioned within the chest cavity of the patient (99).

Abstract translation: 适于植入患者（99）的心脏辅助装置（10）。 装置（10）包括主动脉压缩装置（60），该主动脉压缩装置（60）在致动时适于压缩患者（99）的主动脉（15），流体储存器（74）和泵装置（71） 从所述流体储存器（74）到所述主动脉压缩装置（60），以便至少部分地与所述患者的心脏反搏来致动所述主动脉压缩装置（60）。 流体储存器（74）适于完全定位在患者（99）的胸腔内。