公开(公告)号：WO2017141238A1

公开(公告)日：2017-08-24

申请号：PCT/IL2017/050188

申请日：2017-02-14

Applicant: INOVYTEC MEDICAL SOLUTIONS LTD.

Inventor： KANTOR, Ehud ,  BARKAI, Nir

IPC: A61N1/04 ,  A61K9/70 ,  A61B5/0408

CPC classification number: A61B5/04085 ,  A61B5/04012 ,  A61B5/0416 ,  A61B5/0492 ,  A61B5/6823 ,  A61B5/6833 ,  A61B2505/01 ,  A61B2562/04 ,  A61B2562/12 ,  A61B2562/125 ,  A61B2562/164 ,  A61B2562/242 ,  A61K9/0009 ,  A61K9/703 ,  A61N1/046 ,  A61N1/0492

Abstract: An envelope is comprised of two sheets of material that are placed one on top of each other with their interior sides facing each other with their edges sealed to each other with an adhesive to form an airtight enclosure. The envelope has at least one medical patch inside it that is attached to the interior side of at least one of the sheets and a layer of medical grade pressure sensitive adhesive surrounding the at least one medical patch. The pressure sensitive adhesive is applied to a part of the surface of the interior side of the sheet in order to attach the sheet of material and the at least one medical patch to the body of a patient. The medical patch can be an electrode for measuring a patient's vital signs or delivering an electric shock or a transdermal patch for delivering a drug to a patient.

Abstract translation: 信封由两片材料构成，它们彼此叠置放置，其内侧彼此面对，其边缘用粘合剂彼此密封以形成气密外壳。 所述外壳在其内部具有至少一个贴附在至少一个所述片的内侧上的医疗贴片以及围绕所述至少一个医疗贴片的医用级压敏粘合剂层。 将压敏粘合剂施加到片的内侧的表面的一部分上，以将片材和至少一个医用贴片附着到患者​​的身体。 医用贴片可以是用于测量患者生命体征或传递电击或用于向患者递送药物的透皮贴片的电极。

公开(公告)号：WO2017070295A1

公开(公告)日：2017-04-27

申请号：PCT/US2016/057825

申请日：2016-10-20

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： BRISBEN, Amy Jean ,  ALLAVATAM, Venugopal ,  SIEJKO, Krzysztof Z. ,  MAHAJAN, Deepa ,  WIKA, Kevin G. ,  HERRMANN, Keith L. ,  HAHN, Stephen J.

IPC: A61B5/0402 ,  A61B5/00 ,  A61B5/0456 ,  A61B5/0468 ,  A61B5/0452 ,  A61N1/39 ,  A61B5/04 ,  A61B5/042 ,  A61N1/362 ,  A61B5/0472 ,  A61B5/0245 ,  A61B5/024

CPC classification number: A61N1/36514 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/04028 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/0456 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/72 ,  A61B5/7203 ,  A61B5/7221 ,  A61N1/046 ,  A61N1/05 ,  A61N1/0563 ,  A61N1/3622 ,  A61N1/3625 ,  A61N1/3704 ,  A61N1/3925 ,  A61N1/3956 ,  A61N1/3987

Abstract: Methods and devices for combining multiple signals from multiple sensing vectors for use in wearable or implantable cardiac devices. A preferred sensing configuration may be selected at a given point in time, for example under clinical conditions. Signal quality for the preferred sensing configuration is then monitored, and if the signal quality degrades under selected conditions, re-analysis may be performed to select a different sensing vector configuration for at least temporary use. If signal quality increases for the preferred sensing configuration, temporary use of the different sensing vector configuration may cease and reversion to the preferred sensing configuration takes place if certain conditions are met. The conditions for reversion may depend in part of a history of sensing signal quality for the preferred sensing configuration.

Abstract translation: 用于组合来自多个感测向量的多个信号以用于可穿戴或可植入的心脏装置的方法和设备。 例如在临床条件下，可以在给定的时间点选择优选的感测配置。 然后监测优选感测配置的信号质量，并且如果在选定条件下信号质量下降，则可以执行重新分析以选择至少临时使用的不同感测向量配置。 如果信号质量对于优选的感测配置增加，则可以停止临时使用不同的感测矢量配置，并且如果满足某些条件则可以恢复到优选的感测配置。 回复的条件可能部分取决于优选传感配置的感测信号质量的历史。

公开(公告)号：WO2017070292A1

公开(公告)日：2017-04-27

申请号：PCT/US2016/057821

申请日：2016-10-20

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： BRISBEN, Amy Jean ,  ALLAVATAM, Venugopal ,  MAHAJAN, Deepa ,  SIEJKO, Krzysztof, Z. ,  WIKA, Kevin, G. ,  HERRMANN, Keith, L. ,  HAHN, Stephen, J.

IPC: A61B5/0402 ,  A61B5/00 ,  A61B5/0456 ,  A61N1/39 ,  A61B5/04 ,  A61B5/042

CPC classification number: A61N1/36514 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/04028 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/0456 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/72 ,  A61B5/7203 ,  A61B5/7221 ,  A61N1/046 ,  A61N1/05 ,  A61N1/0563 ,  A61N1/3622 ,  A61N1/3625 ,  A61N1/3704 ,  A61N1/3925 ,  A61N1/3956 ,  A61N1/3987

Abstract: Methods and devices for combining multiple signals from multiple sensing vectors for use in wearable or implantable cardiac devices. Signals from multiple vectors may be combined using weighting factors and/or by conversion to different coordinate systems than the original inputs, which may or may not be normalized to patient anatomy. Signals from multiple sensing vectors may be combined prior to or after several analytical steps or processes including before or after filtering, and before or after cardiac cycle detection. Cardiac cycle detection information may be combined across multiple sensing vectors before or after analysis of individual vectors for noise or overdetection. Cardiac cycle detection information may also be combined across multiple sensing vectors to identify noise and/or overdetection.

Abstract translation: 用于组合来自多个感测向量的多个信号以用于可穿戴或可植入的心脏装置的方法和设备。 来自多个向量的信号可以使用加权因子和/或通过转换到与原始输入不同的坐标系统来组合，其可以或不可以针对患者解剖结构进行归一化。 来自多个感测向量的信号可以在几个分析步骤或过程之前或之后进行组合，包括在过滤之前或之后以及在心动周期检测之前或之后。 心脏周期检测信息可以在分析个体向量之前或之后跨过多个感测向量进行组合以用于噪声或过度检测。 心脏周期检测信息也可以跨越多个感测向量组合以识别噪音和/或过度检测。

公开(公告)号：WO2017058524A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/051833

申请日：2016-09-15

Applicant: ZOLL MEDICAL CORPORATION

Inventor： FREEMAN, Gary A. ,  KAIB, Thomas E. ,  VOLPE, Shane S.

IPC: A61B5/0205

CPC classification number: A61N1/3987 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/02438 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0816 ,  A61B5/1112 ,  A61B5/1118 ,  A61B5/4809 ,  A61B5/4836 ,  A61B5/6805 ,  A61B5/6831 ,  A61B5/746 ,  A61B2560/0242 ,  A61N1/046 ,  A61N1/0484 ,  A61N1/3625 ,  A61N1/3925

Abstract: An ambulatory medical device comprising: a monitoring component comprising at least one sensing electrode for detecting a cardiac condition of a patient; at least one processor configured for: adjusting one or more detection parameters for detecting the cardiac condition of the patient based at least in part on at least one of 1) one or more environmental conditions and 2) input received from the monitoring component; and providing at least one of an alarm and a treatment in response to detecting the cardiac condition of the patient based on the adjusted one or more detection parameters.

Abstract translation: 一种移动医疗装置，包括：监测部件，包括用于检测患者的心脏状况的至少一个感测电极; 至少一个处理器被配置为：至少部分地基于以下至少一个来调整用于检测患者的心脏状况的一个或多个检测参数：1）一个或多个环境条件和2）从所述监视组件接收的输入; 以及响应于基于所调整的一个或多个检测参数来检测患者的心脏状况而提供报警和治疗中的至少一个。

公开(公告)号：WO2016207655A1

公开(公告)日：2016-12-29

申请号：PCT/GB2016/051902

申请日：2016-06-24

Applicant: SKY MEDICAL TECHNOLOGY LTD

Inventor： FENTON, Jonathan ,  ERSAN, Ali ,  BAIN, Duncan ,  TUCKER, Arthur ,  GORDON, Martin

IPC: A61N1/04 ,  A61N1/36

CPC classification number: A61N1/0452 ,  A61N1/0456 ,  A61N1/046 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/36003 ,  A61N1/36007 ,  A61N1/36034

Abstract: The present invention relates to a device for providing neuromuscular stimulation. The device comprises a positive electrode, a plurality of negative electrodes, a non-conductive substrate and a control unit for activating the electrodes. The control unit of the device activates the negative electrodes in a predetermined sequence, so as to deliver electrical stimulus to a user, wherein the predetermined sequence is repeated with an increasing level of stimulus until a predetermined outcome is achieved. Additionally each negative electrode of the devices comprises at least one conductive track mounted on the non-conductive substrate wherein at least one pair of negative electrodes overlap such that the conductive track or tracks of a first negative electrode of the pair overlap with the electrode footprint, but not the conductive tracks, of a second negative electrode of the pair.

Abstract translation: 本发明涉及一种用于提供神经肌肉刺激的装置。 该装置包括正电极，多个负电极，非导电衬底和用于启动电极的控制单元。 该装置的控制单元以预定的顺序激活负电极，以便将电刺激传递给用户，其中以增加的刺激水平重复预定的顺序，直到达到预定的结果为止。 此外，器件的每个负电极包括安装在非导电衬底上的至少一个导电轨道，其中至少一对负电极重叠，使得该对的第一负电极的导电轨迹或轨迹与电极脚迹重叠， 但不是该对的第二负电极的导电轨道。

公开(公告)号：WO2016154425A1

公开(公告)日：2016-09-29

申请号：PCT/US2016/023992

申请日：2016-03-24

Applicant: ZOLL MEDICAL CORPORATION

Inventor： FREEMAN, Gary A. ,  KAUFMAN, Christopher Luke

IPC: A61B5/0402 ,  A61B5/0404 ,  A61B5/0428 ,  A61B5/0452 ,  A61B5/046 ,  A61H31/00

CPC classification number: A61B5/4836 ,  A61B5/0205 ,  A61B5/04286 ,  A61B5/046 ,  A61B5/1118 ,  A61B5/7257 ,  A61B2505/01 ,  A61B2562/17 ,  A61B2562/221 ,  A61H31/005 ,  A61H2031/001 ,  A61H2031/002 ,  A61H2201/0184 ,  A61H2201/10 ,  A61H2201/1619 ,  A61H2201/165 ,  A61H2201/1652 ,  A61H2201/1654 ,  A61H2201/5007 ,  A61H2201/5025 ,  A61H2201/5043 ,  A61H2201/5046 ,  A61H2201/5048 ,  A61H2201/5079 ,  A61H2201/5097 ,  A61H2230/00 ,  A61H2230/045 ,  A61H2230/06 ,  A61H2230/08 ,  A61H2230/207 ,  A61H2230/30 ,  A61H2230/42 ,  A61H2230/60 ,  A61H2230/65 ,  A61N1/046 ,  A61N1/0484 ,  A61N1/3625 ,  A61N1/36507 ,  A61N1/39044 ,  A61N1/3925 ,  A61N1/3968 ,  A61N1/3987 ,  A61N1/3993

Abstract: A medical monitoring and treatment device that includes a therapy delivery interface, a plurality of therapy electrodes coupled to the therapy delivery interface, a plurality of electrocardiogram sensing electrodes to sense electrocardiogram signals of a patient, a sensor interface to receive the electrocardiogram signals and digitize the electrocardiogram signals, and at least one processor coupled to the sensor interface and the therapy delivery interface to analyze the digitized electrocardiogram signals, to detect a cardiac arrhythmia based on the digitized electrocardiogram signals, and to control the therapy delivery interface to apply electrical therapy to the patient based upon the detected cardiac arrhythmia. The at least one processor is further configured to analyze a frequency domain transform of the digitized electrocardiogram signals, to determine a metric indicative of a metabolic state of a heart of the patient, and to accelerate or delay application of the electrical therapy based upon the metric.

Abstract translation: 一种医疗监视和治疗装置，其包括治疗递送界面，耦合到治疗递送界面的多个治疗电极，用于感测患者的心电图信号的多个心电图感测电极，用于接收心电图信号的传感器接口和数字化 心电图信号，以及耦合到传感器接口和治疗传递界面的至少一个处理器，以分析数字化的心电图信号，以基于数字化的心电图信号检测心律不齐，并且控制治疗传递界面以将电疗法应用于 患者基于检测到的心律失常。 所述至少一个处理器还被配置为分析所述数字化心电图信号的频域变换，以确定指示所述患者心脏的代谢状态的度量，并且基于所述度量来加速或延迟所述电疗法的应用 。

公开(公告)号：WO2016077786A1

公开(公告)日：2016-05-19

申请号：PCT/US2015/060730

申请日：2015-11-13

Applicant: ZOLL MEDICAL CORPORATION ,  WENG, Binwei ,  JOHNSON, Guy R.

Inventor： WENG, Binwei ,  JOHNSON, Guy R. ,  SULLIVAN, Adam ,  NICOLO, Francesco ,  SZYMKIEWICZ, Steve ,  FREEMAN, Gary A. ,  FRANK, Gregory R. ,  WHITING, Jason T. ,  RINGQUIST, Steve ,  KAIB, Thomas E.

IPC: G06F19/00

CPC classification number: A61B5/04012 ,  A61B5/0006 ,  A61B5/0059 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/0533 ,  A61B5/085 ,  A61B5/1118 ,  A61B5/14552 ,  A61B5/4803 ,  A61B5/686 ,  A61B5/7267 ,  A61B5/7275 ,  A61B7/003 ,  A61B7/04 ,  A61B8/0883 ,  A61N1/046 ,  A61N1/0484 ,  A61N1/37211 ,  A61N1/3925 ,  A61N1/3975 ,  G06F19/00

Abstract: A system and method for medical premonitory event estimation includes one or more processors to perform operations comprising: acquiring a first set of physiological information of a subject, and a second set of physiological information of the subject received during a second period of time; calculating first and second risk scores associated with estimating a risk of a potential cardiac arrhythmia event for the subject based on applying the first and second sets of physiological information to one or more machine learning classifier models, providing at least the first and second risk scores associated with the potential cardiac arrhythmia event as a time changing series of risk scores, and classifying the first and second risk scores associated with estimating the risk of the potential cardiac arrhythmia event for the subject based on the one or more thresholds.

Abstract translation: 用于医疗预兆事件估计的系统和方法包括一个或多个处理器，用于执行操作，包括：获取对象的第一组生理信息和在第二时间段期间接收的对象的第二组生理信息; 基于将所述第一和第二组生理信息应用于一个或多个机器学习分类器模型来计算与估计所述受试者的潜在心律失常事件的风险相关联的第一和第二风险评分，提供至少相关联的第一和第二风险分数 将潜在的心律失常事件作为时间变化的一系列风险评分，并且基于一个或多个阈值来分类与估计受试者的潜在心律失常事件的风险相关联的第一和第二风险评分。

公开(公告)号：WO2016069862A1

公开(公告)日：2016-05-06

申请号：PCT/US2015/057993

申请日：2015-10-29

Applicant: ZOLL MEDICAL CORPORATION

Inventor： FREEMAN, Gary, A. ,  HERKEN, Ulrich ,  KAUFMAN, Christopher ,  SILVER, Annemarie, Elizabeth

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/1477

CPC classification number: A61B5/684 ,  A61B5/0075 ,  A61B5/02 ,  A61B5/0402 ,  A61B5/14539 ,  A61B5/6823 ,  A61B5/7246 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B2560/0425 ,  A61B2562/0219 ,  A61N1/046 ,  A61N1/39

Abstract: A method for measuring a myocardial physiologic parameter according to an embodiment includes placing an at least partially convex portion of a spectral sensor against an intercostal space of a human over a heart of the human and measuring the physiologic parameter of a myocardium of the heart with the spectral sensor over time during an emergency medical event. The spectral sensor may be configured to determine and visually display a suggested position adjustment for directing the spectral radiation more directly toward the tissue of interest (e.g. the myocardium), and/or for placing the operative elements of the spectral sensor closer to the tissue of interest (e.g. the myocardium).

Abstract translation: 根据实施例的用于测量心肌生理参数的方法包括将光谱传感器的至少部分凸起的部分放置在人的心脏上的肋间空间上，并且测量心脏的心肌的生理参数， 频谱传感器随着时间的推移在紧急医疗事件。 光谱传感器可以被配置为确定并可视地显示建议的位置调整，用于更直接地将光谱辐射引导到感兴趣的组织（例如，心肌），和/或用于将光谱传感器的操作元件更靠近组织 兴趣（如心肌）。

公开(公告)号：WO2016058004A1

公开(公告)日：2016-04-14

申请号：PCT/US2015/055330

申请日：2015-10-13

Applicant: RUSE TECHNOLOGIES, LLC ,  IDEKER, Raymond, E. ,  RUSE, Richard, B. ,  BOHANAN, Scott

Inventor： IDEKER, Raymond, E. ,  RUSE, Richard, B. ,  BOHANAN, Scott

IPC: A61H31/00

CPC classification number: A61N1/3906 ,  A61N1/046 ,  A61N1/0492 ,  A61N1/3625 ,  A61N1/39

Abstract: A method and apparatus for treating a cardiac condition in a human or animal patient comprises contacting an area of skin spanning the chest area of the patient with at least two patches or electrode paddles that apply low voltages and currents in a rotational manner to pre- stimulate that area, followed by applying a high voltage shock in rapid succession through the patient's heart through at least two electrode pad patches or paddles, wherein an amplifier-based external defibrillation cardioversion system is used. Also, an external pacing system is employed using ascending ramp or any arbitrary ascending or level waveform for transcutaneous pacing which employ a constant current delivery mode. Treatable conditions include atrial fibrillation (AF), atrial tachycardia (AT), ventricular fibrillation (VF), and ventricular tachycardia (VT).

Abstract translation: 用于治疗人或动物患者的心脏病症的方法和装置包括使穿过患者胸部区域的皮肤区域与至少两个以旋转方式施加低电压和电流的贴片或电极片接触以预刺激 然后通过患者的心脏通过至少两个电极垫片或桨片快速连续施加高电压冲击，其中使用基于放大器的外部除颤心脏复律系统。 此外，采用使用恒定电流传送模式的经皮起搏的上升斜坡或任意上升或电平波形使用外部起搏系统。 可治疗的病症包括心房颤动（房颤），房性心动过速（AT），室颤（VF）和室性心动过速（VT）。

公开(公告)号：WO2015189275A1

公开(公告)日：2015-12-17

申请号：PCT/EP2015/062949

申请日：2015-06-10

Applicant: METRAX GMBH

Inventor： FOTSO, Martial Desiré ,  MABROUK, Ziad ,  VON WAGNER, Gero

IPC: A61N1/39 ,  A61H31/00

CPC classification number: A61H31/005 ,  A61H31/007 ,  A61H2031/002 ,  A61H2201/5061 ,  A61H2201/5064 ,  A61H2201/5069 ,  A61H2201/5071 ,  A61H2230/206 ,  A61H2230/208 ,  A61H2230/255 ,  A61H2230/405 ,  A61H2230/655 ,  A61N1/046 ,  A61N1/0492 ,  A61N1/3968

Abstract: Die Erfindung bezieht sich auf eine Vorrichtung zur Unterstützung des Rettungspersonals bei der Durchführung einer Herz-Lungen-Wiederbelegung mit einer Überwachungseinrichtung für die Herzdruckmassage, die mindestens eine Sensoreinheit (1) für die Druckbetätigung und eine Verarbeitungsvorrichtung (2) für ihr zugeführte Sensorsignale aufweist. Vorteile für den Aufbau und die Funktion ergeben sich dadurch, dass die Sensoreinheit (1) mindestens ein Dehnungssensorelement (10) aus einem seine elektrischen Eigenschaften bei Dehnung ändernden Material um- fasst und mit einer Haltevorrichtung versehen ist, mittels deren das mindestens eine Dehnungssensorelement (10) bezüglich der Brust der zu rettenden Person in der Weise fixierbar ist, dass das mindestens eine Dehnungssensorelement (10) synchron mit der Druckbetätigung verformt wird und dadurch das Sensorsignal gebildet wird.

Abstract translation: 本发明涉及一种设备，用于在与用于胸部按压的按压操作的监控装置，至少一个传感器单元（1）和（2），用于向其提供的传感器信号处理装置执行心肺复苏支撑救援人员。 其建造和从一个事实，即在传感器单元（1）一个其电特性中的至少一个应变传感器元件（10）总结环境改变材料时拉伸并设置有保持装置，借助于该函数的结果优点，至少一个应变传感器元件（10 ）是相对于所述胸部人在固定的方式获救，至少一个应变传感器元件（10）变形同步地在打印操作和由此形成的传感器信号。