Abstract:
The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.
Abstract:
A host material may be used for the separation of elements or compounds, wherein the host material is an organic molecular solid with suitable cavities for accommodating a guest material to be separated, and with interconnections between the cavities to allow the guest material to diffuse through the host material, and wherein said interconnections are closed for a proportion of the time or have a static pore limiting diameter which is smaller than the static dimension of the guest material. Applications include separations of rare gases, chiral molecules, and alkanes. One class of suitable host materials may be made by imine condensation.
Abstract:
L'invention concerne un procédé de fabrication d'une colonne d'analyse de chromatographie, la colonne ainsi obtenue et un dispositif comprenant une telle colonne. Le procédé de l'invention comprend les étapes de : a) dépôt d'une première couche de particules, destinées à former la phase stationnaire, sur la surface plane d'un substrat, b) dépôt d'au moins une seconde couche de particules en assemblage compact sur la couche, c) imprégnation des première et seconde couches avec un matériau sensible à un rayonnement lumineux, pour former au moins deux couches de particules en assemblage compact imprégnées de matériau sensible, d) insolation de ces couches dans les zones correspondant à la forme interne voulue de la colonne d'analyse de chromatographie, lorsque le matériau sensible au rayonnement lumineux se comporte comme une résine positive, ou détourant cette forme interne, lorsque le matériau sensible au rayonnement lumineux se comporte comme une résine photosensible négative, e) élimination soit des zones insolées à l'étape d), lorsque le matériau sensible au rayonnement lumineux se comporte comme une résine photosensible positive, soit des zones non insolées à l'étape d), lorsque le matériau sensible au rayonnement lumineux se comporte comme une résine photosensible négative, et d) recouvrement et scellement de la structure obtenue à l'étape e) avec un capot recouvert sur sa face tournée vers les couches d'au moins une couche de particules en assemblage compact identiques ou différentes à celles déposées sur la surface du substrat. L'invention trouve application dans le domaine de l'analyse chimique, en particulier.
Abstract:
Methods and compositions are provided for treatment of an apatite-based resin from which retained solutes have been eluted by an elution buffer that contains an alkali metal salt with solutions of calcium ion, phosphate ion, and hydroxide separately from any sample loading and elution buffers. The treatment solutions restore the resin, reversing the deterioration that is caused by the alkali metal salt in the elution buffer.
Abstract:
The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
Abstract:
In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, acid-base stable highly cross- linked polymers, acid-base stable at least partially cross-linked polymers, titania, alumina, thoria combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction.
Abstract:
Purification methods for fullerene derivatives are described. The method comprises passing a solution of fullerene derivatives containing impurities such as other fullerene derivatives and polycyclic aromatic hydrocarbons through activated charcoals. Fullerene derivatives with high purity were obtained.
Abstract:
Procedimiento para la purificación de triglicéridos que contienen ácido gamma- linolénico en posición sn-2. Con la finalidad de purificar triglicéridos que contienen ácido gamma- linolénico a partir de fuentes naturales, se utiliza una columna cromatográfica gravimétrica en fase normal, trabajando en gradiente de polaridad con solventes biocompatibles. Así se consigue la purificación de triglicéridos que cuentan en su estructura con una o más moléculas de ácido gamma -linolénico, pudiendo ser utilizados con diversos fines. Con esta metodología es posible trabajar a escala industrial, pues es fácilmente escalable, a diferencia de otras técnicas que son aplicables a escala analítica pero presentan serios inconvenientes en cuanto a coste y adiestramiento del personal a la hora de utilizarlas con fines industriales, como por ejemplo la cromatografía líquida de alta resolución (HPLC).
Abstract:
Selecting a stationary phase for a fluid analyzer using certain criteria to determine an appropriate material for use in, for instance, a micro fluid analyzer. High absorption of an analyte or sample, low water sorbency and high porosity or permeability of the material may be sought. A selected material may incorporate a toughening agent using a neutral leaving group. A selected material may have a capping agent to promote hydrophobicity. A selected material may be a hydrophobic polymer. The selection of a stationary phase may involve molecular modeling.
Abstract:
A carbonaceous material is derived from a polysaccharide by carbonisation. The polysaccharide is preferably a starch. The carbonaceous material has mesoporosity and is useful as a solid catalytic support.