公开(公告)号：WO2006010775A1

公开(公告)日：2006-02-02

申请号：PCT/EP2005/053728

申请日：2005-07-29

Applicant: Laboratorios S.A.L.V.A.T., S.A. ,  SERRA COMAS, Carmen ,  FERNANDEZ SERRAT, Anna ,  BALSA LOPEZ, Dolors ,  MASIP MASIP, Isabel ,  CATENA RUIZ, Juan Lorenzo ,  HIDALGO RODRIGUEZ, José ,  LAGUNAS ARNAL, Carmen ,  SALCEDO ROCA, Carolina ,  FERNANDEZ GARCIA, Andrés

Inventor： SERRA COMAS, Carmen ,  FERNANDEZ SERRAT, Anna ,  BALSA LOPEZ, Dolors ,  MASIP MASIP, Isabel ,  CATENA RUIZ, Juan Lorenzo ,  HIDALGO RODRIGUEZ, José ,  LAGUNAS ARNAL, Carmen ,  SALCEDO ROCA, Carolina ,  FERNANDEZ GARCIA, Andrés

IPC: C07C233/88 ,  C07C229/36 ,  C07C233/20 ,  C07C233/69 ,  A61K31/198 ,  A61K31/341 ,  A61K31/4406 ,  A61P3/04 ,  A61P3/10 ,  C07D213/56 ,  C07D307/54 ,  C07D215/14 ,  A61K31/47

CPC classification number: C07D213/81 ,  C07C229/36 ,  C07C233/20 ,  C07C233/24 ,  C07C233/60 ,  C07C233/69 ,  C07C233/88 ,  C07C2601/02 ,  C07C2601/04 ,  C07D213/56 ,  C07D213/82 ,  C07D215/48 ,  C07D217/26 ,  C07D241/24 ,  C07D241/44 ,  C07D307/52 ,  C07D307/54 ,  C07D307/68 ,  C07D333/20 ,  C07D333/24 ,  C07D333/38

Abstract: Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents -(CH 2 ) s -N(COR 3 )-A-J-T or -(CH 2 ) S -N(R 4 )-B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPARγ modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.

Abstract translation: 通式I的化合物及其盐和溶剂合物，其中R1表示2-苯甲酰基苯基; R2表示 - （CH

公开(公告)号：WO00043368A1

公开(公告)日：2000-07-27

申请号：PCT/FR2000/000143

申请日：2000-01-21

IPC: C07D295/10 ,  A61K8/00 ,  A61K8/22 ,  A61K8/41 ,  A61K8/49 ,  A61Q5/10 ,  C07C233/24 ,  C07C233/88 ,  C07D233/56 ,  C07D233/60 ,  D06P3/08 ,  A61K7/13

CPC classification number: A61Q5/10 ,  A61K8/42 ,  C07C233/24

Abstract: The invention concerns novel cationic 2-acylaminophenols of formula (I) comprising at least a cationic group, their use as coupler for oxidation dyeing of keratin fibres and in particular human keratin fibres such as hair, oxidation dyeing compositions containing them combined with at least an oxidation base, and oxidation dyeing methods using them.

Abstract translation: 本发明涉及至少包含阳离子基团的式（I）的阳离子2-酰基氨基苯酚，它们作为角蛋白纤维氧化染色，特别是人角蛋白纤维如毛发的成色剂的用途，含有它们的氧化染色组合物与至少一种 氧化碱和氧化染色方法。

公开(公告)号：WO2012076466A3

公开(公告)日：2012-08-30

申请号：PCT/EP2011071747

申请日：2011-12-05

Applicant: BAYER PHARMA AG ,  LAMPE THOMAS ,  HAHN MICHAEL G ,  STASCH JOHANNES-PETER ,  SCHLEMMER KARL-HEINZ ,  WUNDER FRANK ,  EL SHEIKH SHERIF ,  LI VOLKHART MIN-JIAN ,  BECKER EVA-MARIA ,  STOLL FRIEDERIKE ,  KNORR ANDREAS ,  KOLKHOF PETER ,  WOLTERING ELISABETH

Inventor： LAMPE THOMAS ,  HAHN MICHAEL G ,  STASCH JOHANNES-PETER ,  SCHLEMMER KARL-HEINZ ,  WUNDER FRANK ,  EL SHEIKH SHERIF ,  LI VOLKHART MIN-JIAN ,  BECKER EVA-MARIA ,  STOLL FRIEDERIKE ,  KNORR ANDREAS ,  KOLKHOF PETER ,  WOLTERING ELISABETH

IPC: C07C233/24

CPC classification number: C07C231/02 ,  A61K31/196 ,  C07C233/24 ,  C07C233/55

Abstract: The present application relates to novel substituted 1-benzyl­cycloalkyl­carboxylic acid derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of disorders and to the use thereof for production of medicaments for treatment and/or prevention of disorders, especially for treatment and/or prevention of cardiovascular disorders.

Abstract translation: 本申请涉及新的取代的1-Benzylcycloalkylcarbonsäure衍生物，用于治疗和/或预防它们的制备方法，其用于疾病的治疗和/或预防和它们用于制备药物用于治疗和/或预防的疾病中的用途的用途，特别 心血管疾病。

公开(公告)号：WO2006010775A8

公开(公告)日：2006-06-15

申请号：PCT/EP2005053728

申请日：2005-07-29

Applicant: S A L V A T LAB SA ,  SERRA COMAS CARMEN ,  FERNANDEZ SERRAT ANNA ,  BALSA LOPEZ DOLORS ,  MASIP MASIP ISABEL ,  CATENA RUIZ JUAN LORENZO ,  HIDALGO RODRIGUEZ JOSE ,  LAGUNAS ARNAL CARMEN ,  SALCEDO ROCA CAROLINA ,  FERNANDEZ GARCIA ANDRES

Inventor： SERRA COMAS CARMEN ,  FERNANDEZ SERRAT ANNA ,  BALSA LOPEZ DOLORS ,  MASIP MASIP ISABEL ,  CATENA RUIZ JUAN LORENZO ,  HIDALGO RODRIGUEZ JOSE ,  LAGUNAS ARNAL CARMEN ,  SALCEDO ROCA CAROLINA ,  FERNANDEZ GARCIA ANDRES

IPC: C07C233/88 ,  A61K31/198 ,  A61K31/341 ,  A61K31/4406 ,  A61K31/47 ,  A61P3/04 ,  A61P3/10 ,  C07C229/36 ,  C07C233/20 ,  C07C233/69 ,  C07D213/56 ,  C07D215/14 ,  C07D307/54

CPC classification number: C07D213/81 ,  C07C229/36 ,  C07C233/20 ,  C07C233/24 ,  C07C233/60 ,  C07C233/69 ,  C07C233/88 ,  C07C2601/02 ,  C07C2601/04 ,  C07D213/56 ,  C07D213/82 ,  C07D215/48 ,  C07D217/26 ,  C07D241/24 ,  C07D241/44 ,  C07D307/52 ,  C07D307/54 ,  C07D307/68 ,  C07D333/20 ,  C07D333/24 ,  C07D333/38

Abstract: Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents -(CH 2 ) s -N(COR 3 )-A-J-T or -(CH 2 ) S -N(R 4 )-B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPAR? modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.

Abstract translation: 通式I的化合物及其盐和溶剂化物，其中R1代表2-苯甲酰基苯基; R 2表示 - （CH 2 CH 2）n -N（COR 3） - ， - 或 - （CH 2 2） _{取值 -N（R 4 ） - BJT; 和s，R3，R4，A，B，J和T具有说明书中公开的含义。 这些化合物是PPAR？ 因此，可用于治疗或预防由这些受体介导的疾病或疾病。}

公开(公告)号：WO2012076466A2

公开(公告)日：2012-06-14

申请号：PCT/EP2011/071747

申请日：2011-12-05

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT ,  LAMPE, Thomas ,  HAHN, Michael, G. ,  STASCH, Johannes-Peter ,  SCHLEMMER, Karl-Heinz ,  WUNDER, Frank ,  EL SHEIKH, Sherif ,  LI, Volkhart Min-Jian ,  BECKER, Eva-Maria ,  STOLL, Friederike ,  KNORR, Andreas ,  KOLKHOF, Peter ,  WOLTERING, Elisabeth

Inventor： LAMPE, Thomas ,  HAHN, Michael, G. ,  STASCH, Johannes-Peter ,  SCHLEMMER, Karl-Heinz ,  WUNDER, Frank ,  EL SHEIKH, Sherif ,  LI, Volkhart Min-Jian ,  BECKER, Eva-Maria ,  STOLL, Friederike ,  KNORR, Andreas ,  KOLKHOF, Peter ,  WOLTERING, Elisabeth

IPC: C07C233/24

CPC classification number: C07C231/02 ,  A61K31/196 ,  C07C233/24 ,  C07C233/55

Abstract: Die vorliegende Anmeldung betrifft neue substituierte 1-Benzylcycloalkylcarbonsäure-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prävention von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere zur Behandlung und/oder Prävention kardiovaskulärer Erkrankungen.

Abstract translation: 本申请涉及新的取代的1-Benzylcycloalkylcarbonsäure衍生物，用于治疗和/或预防它们的制备方法，其用于疾病的治疗和/或预防和它们用于制备药物用于治疗和/或预防的疾病中的用途的用途，特别 心血管疾病。

公开(公告)号：WO2004005372A1

公开(公告)日：2004-01-15

申请号：PCT/US2002/021433

申请日：2002-07-05

Applicant: GENERAL ELECTRIC COMPANY

Inventor： PICKETT, James, Edward ,  SICLOVAN, Tiberiu, Mircia ,  SURIANO, Joseph, Anthony ,  BRUNELLE, Daniel, Joseph

IPC: C08G64/12

CPC classification number: C07C233/24 ,  C07C69/63 ,  C08G64/12

Abstract: In one embodiment the preset invention is a polycarbonate comprising structural units derived from at least one dihydric phenol, a carbonate precursor, and at least one member selected from the group consisting of an oxanilide-comprising compound, an oxamate-comprising compound, and mixtures thereof. In another embodiment the present invention is a method for making a polycarbonate comprising structural units derived from at least one dihydric phenol and at least one member selected from the group consisting of an oxanilide-comprising compound, an oxamate-comprising compound, and mixtures thereof, which comprises the step of contacting under reactive conditions at least one dihydric phenol, a carbonate precursor, and at least one member selected from the group consisting of an oxanilide-comprising compound, an oxamate-comprising compound, and mixtures thereof. In still another embodiment the present invention is an article comprising a policarbonate comprising oxanilide structural units. In still another embodiment the present invention is a method for making a symmetrical or unsymmetrical oxanilide-comprising dihydric phenol which comprises the step of contacting at least one aromatic amine bearing a hydroxy group with a diaryl oxalate or a dialkyl oxalate bearing alkyl groups each substituted with at least one electron-withdrawing group. In still another embodiment the present invention is a method for making an oxamate-comprising monohydric phenol which comprises the step of contacting an aromatic amine bearing a hydroxy group with a diaryl oxalate or a dialkyl oxalate bearing alkyl groups each substituted with at least one electron-withdrawing group.

Abstract translation: 在一个实施方案中，本发明是包含衍生自至少一种二元酚，碳酸酯前体和至少一种选自由含草酰替苯的化合物，含草酸酯化合物及其混合物组成的组中的至少一种的结构单元的聚碳酸酯 。 在另一个实施方案中，本发明是一种制备聚碳酸酯的方法，该聚碳酸酯包含衍生自至少一种二元酚的结构单元和至少一种选自由含草酰替苯的化合物，含草酸酯化合物及其混合物组成的组， 其包括在反应条件下使至少一种二元酚，碳酸酯前体和选自由含草酰替苯的化合物，含草酸酯化合物及其混合物中的至少一种接触的步骤。 在另一个实施方案中，本发明是包含含有草酰替苯胺结构单元的碳酸氢盐的制品。 在另一个实施方案中，本发明是一种制备包含对称或不对称的草酰替苯胺的二元酚的方法，其包括使至少一种带有羟基的芳族胺与草酸二芳基酯或带有烷基的二烷基酯的烷基基团接触的步骤， 至少一个吸电子基团。 在另一个实施方案中，本发明是一种制备含草酸羟基的一元酚的方法，其包括使带有羟基的芳族胺与草酸二芳基酯或带有烷基的草酸二烷基酯接触的步骤，每个烷基取代有至少一个电子 - 退出组。