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    SYNTHESIS OF SUBSTITUTED AMIDOBENZOATE COMPOUNDS, THE COMPOUNDS OBTAINED AND THE USE THEREOF AS PHTHALATE FREE INTERNAL ELECTRON DONOR FOR POLYMERIZATION OF OLEFINS
    4.
    发明申请
    SYNTHESIS OF SUBSTITUTED AMIDOBENZOATE COMPOUNDS, THE COMPOUNDS OBTAINED AND THE USE THEREOF AS PHTHALATE FREE INTERNAL ELECTRON DONOR FOR POLYMERIZATION OF OLEFINS 审中-公开
    合成取代的酰胺苯甲酸酯化合物，得到的化合物及其用作用于烯烃聚合的邻苯二甲酸酐自由内给电子体的用途

    公开(公告)号：WO2017050870A9

    公开(公告)日：2018-01-25

    申请号：PCT/EP2016072508

    申请日：2016-09-22

    Applicant: SABIC GLOBAL TECHNOLOGIES BV

    Inventor： ZUIDEVELD MARTIN ALEXANDER ,  SAINANI JAIPRAKASH BRIJLAL ,  AL-HUMAIDAN OSAMAH ,  PADMANABHAN SUDHAKAR R ,  SHINGE PRASHANT SUKUMAR ,  SHETTY SHARANKUMAR ,  SHAIKH ABBAS-ALLI GHUDUBHAI

    IPC: C07C231/14 ,  C07C233/75 ,  C07C233/88 ,  C08F4/654 ,  C08F4/656 ,  C08F110/06

    CPC classification number: C08F4/6565 ,  C07C231/14 ,  C07C233/75 ,  C08F110/06 ,  C08F4/651 ,  C08F2500/15 ,  C08F2500/18

    Abstract: The present invention relates to a compound according to Formula (I) wherein R1 is a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, and alkylaryl groups, and one or more combinations thereof; wherein R2 is a hydrogen atom, an aryl group or an alkyl group; and wherein R3, R4, R5 and R6, are the same or different and are each independently a hydrogen atom, a halogen atom, a cyano group, an amino group, a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, and alkylaryl groups or an alkoxy group, and one or more combinations thereof as internal electron donor and to a process for the synthesis of a compound according to Formula (I), wherein R1 is a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, alkoxycarbonyl and alkylaryl groups, and one or more combinations thereof; wherein R2 is a hydrogen atom or an alkyl group; wherein R3, R4, R5 and R6, are the same or different and are each independently selected from a group consisting of a hydrogen atom; a hydrocarbyl, preferably, said process comprising the step of reacting a compound according to Formula (II) [R1- C(=O)Cl] with a compound according to Formula (III) to obtain the compound according to Formula (I) and to the use of these compounds as internal donor in Ziegler-Natta catalysis of olefins.

    Abstract translation: 本发明涉及根据式（I）的化合物，其中R 1为选自烷基，烯基，芳基，芳烷基和烷基芳基以及它们的一种或多种组合的烃基; 其中R2是氢原子，芳基或烷基; 并且其中R 3，R 4，R 5和R 6相同或不同并且各自独立地为氢原子，卤素原子，氰基，氨基，选自烷基，链烯基，芳基， 芳烷基和烷基芳基或烷氧基，以及它们的一种或多种组合作为内电子给体，并且涉及合成式（I）化合物的方法，其中R 1是选自下列的烃基：烷基 ，烯基，芳基，芳烷基，烷氧基羰基和烷基芳基以及它们的一种或多种组合; 其中R2是氢原子或烷基; 其中R 3，R 4，R 5和R 6相同或不同，并且各自独立地选自氢原子; 所述方法包括使根据式（II）的化合物[R 1 -C（= O）Cl]与根据式（III）的化合物反应以获得根据式（I）的化合物和 涉及这些化合物在齐格勒 - 纳塔催化烯烃中作为内给体的用途。

    SUBSTITUTED STILBENES AS GLUCOSE UPTAKE ENHANCERS
    6.
    发明申请
    SUBSTITUTED STILBENES AS GLUCOSE UPTAKE ENHANCERS 审中-公开
    取代的胶原蛋白作为葡萄糖摄取增强剂

    公开(公告)号：WO01094295A1

    公开(公告)日：2001-12-13

    申请号：PCT/US2001/017673

    申请日：2001-06-01

    IPC: C07D317/68 ,  A61K31/196 ,  A61K31/24 ,  A61K31/245 ,  A61K31/36 ,  A61K45/00 ,  A61P3/10 ,  C07C231/02 ,  C07C231/12 ,  C07C233/81 ,  C07C233/88 ,  C07C235/56 ,  C07C235/64 ,  C07C235/84 ,  C07C237/40 ,  C07C237/42 ,  C07C309/51 ,  C07C309/61 ,  C07D317/60

    CPC classification number: C07C233/81 ,  C07C233/88 ,  C07C235/56 ,  C07C235/64 ,  C07C235/84 ,  C07C237/40 ,  C07C237/42 ,  C07C309/51 ,  C07C309/61 ,  C07D317/60

    Abstract: The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, methods of treatment administering these compounds to mammalian hosts, and processes for their preparation. Specifically, the invention relates to a means to enhance insulin-dependent glucose uptake. More specifically, the invention concerns compounds and pharmaceutical compositions that activate the insulin receptor kinase, which leads to increased sensitivity to insulin and an increase in glucose uptake, as well as processes for the preparation of the compounds. The invention also specifically concerns methods for treating humans with hyperglycemia, especially for the treatment of Type II diabetes.

    Abstract translation: 本发明涉及化合物，包含所述化合物的药物组合物，将哺乳动物宿主施用这些化合物的方法及其制备方法。 具体地，本发明涉及一种增强胰岛素依赖性葡萄糖摄取的方法。 更具体地，本发明涉及激活胰岛素受体激酶的化合物和药物组合物，其导致对胰岛素的增加的敏感性和葡萄糖摄取的增加以及制备化合物的方法。 本发明还具体涉及用于治疗高血糖患者的方法，尤其涉及用于治疗II型糖尿病的方法。

    18F-LABELED DAA ANALOGUES AND METHODS OF LABELING THESE ANALOGUES AS POSITRON EMISSION TOMOGRAPHY (PET) TRACERS FOR IMAGING PERIPHERAL BENZODIAZEPINE RECEPTORS
    10.
    发明申请
    18F-LABELED DAA ANALOGUES AND METHODS OF LABELING THESE ANALOGUES AS POSITRON EMISSION TOMOGRAPHY (PET) TRACERS FOR IMAGING PERIPHERAL BENZODIAZEPINE RECEPTORS 审中-公开
    18F标记的DAA模拟物和标记这些模拟物作为用于成像外周苯二氮酮受体的POSITRON排放成像（PET）追踪器的方法

    公开(公告)号：WO2007060517A1

    公开(公告)日：2007-05-31

    申请号：PCT/IB2006/003281

    申请日：2006-11-20

    Applicant: GE HEALTHCARE LIMITED ,  KARIMI, Farhad ,  LANGSTROM, Bengt ,  RAHMAN, Obaidur ,  ESTRADA, Sergio

    Inventor： KARIMI, Farhad ,  LANGSTROM, Bengt ,  RAHMAN, Obaidur ,  ESTRADA, Sergio

    IPC: C07B59/00 ,  C07C233/88

    CPC classification number: C07B59/001 ,  C07C233/88

    Abstract: Methods for selecting novel DAA analogues for a peripheral type benzodiazepine receptor were labeled with 18 F using one-step syntheses are provided. Analogues labeled with the 18 F using the one-step synthesis method are also provided. Additionally, the purification of the Br, I, C1, TsO, MsO, or R f SO 3 precursors in the compound of formula (II) by solid phase extraction is provided as is the precursor compounds of formula (II). Kit and method of use claims for comprising an effective amount of an 18 F labeled compound, and pharmaceutically acceptable salts and solvates thereof are also provided.

    Abstract translation: 选择用于外周型苯二氮卓受体的新型DAA类似物的方法使用一步合成用 18F标记。 还提供了使用一步合成方法用 18F标记的类似物。 另外，提供通过固相萃取来纯化式（II）化合物中的Br，I，Cl，TsO，MsO或R 1 SO 3 N 3前体 式（II）的前体化合物也是如此。 还提供了包含有效量的18 F标记化合物及其药学上可接受的盐和溶剂化物的试剂盒和使用方法。

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