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    SUBSTITUTED CARBOXYLIC CETO-ACIDS,PROCESS FOR THE PREPARATION THEREOF,USE THEREOF AND MEDICINAL COMPOSITIONS CONTAINING THEM
    1.
    发明申请
    SUBSTITUTED CARBOXYLIC CETO-ACIDS,PROCESS FOR THE PREPARATION THEREOF,USE THEREOF AND MEDICINAL COMPOSITIONS CONTAINING THEM 审中-公开
    取代的羧甲基纤维素，其制备方法，其用途及含有它们的药物组合物

    公开(公告)号：WO1981001285A1

    公开(公告)日：1981-05-14

    申请号：PCT/EP1980000123

    申请日：1980-10-31

    申请人： BYK GULDEN LOMBERG CHEM FAB GMBH ,  KRAAS E ,  WOLF H

    发明人： BYK GULDEN LOMBERG CHEM FAB GMBH ,  LUDWIG G ,  RAPP E

    IPC分类号： C07C51/09

    CPC分类号： C07F3/08 ,  C07C29/36 ,  C07C59/84 ,  C07C59/88 ,  C07C59/90 ,  C07F3/02 ,  Y10S514/866 ,  C07C33/46

    摘要： Substituted carboxylic ceto-acids having the formula I (FORMULA) wherein R1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl, lower alkyloxy or trifluoromethyl residue. R2 represents a hydrogen or halogen atom and n represents an integer from 3 to 8. These acids, as well as the salts thereof exhibit an hypoglycemic activity when applied to living homeothermic organisms. Preparation processes for these new compounds and intermediate compounds of the synthesis thereof are described. A preparation of medicinal compositions containing such acids or the salt thereof is also referred to.

    摘要翻译： PCT No.PCT / EP80 / 00123 Sec。 371日期1981年6月29日第 102（e）日期1981年6月29日PCT提交1980年10月31日PCT公布。 出版物WO81 / 01285 日期：1981年5月14日。式I的取代的氧代羧酸（I）其中R1表示氢原子，卤素原子，羟基，低级烷基，低级烷氧基或三氟甲基，R2表示 氢原子或卤素原子，n表示3〜8的整数，它们的盐在温血动物中显示低血糖作用。 描述了制备新化合物及其制备所需的中间产物以及相应药物的方法。

    A METHOD OF SYNTHESIS OF CDL2 COMPLEX WITH HIGH BIOLOGICAL ACTIVITY AGAINST AT LEAST CHLOROQUINE RESISTANT STRAIN OF THE MALARIA PARASITE PLASMODIUM FALCIPARUM
    4.
    发明申请
    A METHOD OF SYNTHESIS OF CDL2 COMPLEX WITH HIGH BIOLOGICAL ACTIVITY AGAINST AT LEAST CHLOROQUINE RESISTANT STRAIN OF THE MALARIA PARASITE PLASMODIUM FALCIPARUM 审中-公开
    一种合成具有高生物活性的CDL2复合物的方法，用于疟原虫PLASMODIUM FALCIPARUM的最低氯霉素抗性菌株

    公开(公告)号：WO2011132028A1

    公开(公告)日：2011-10-27

    申请号：PCT/IB2010/055282

    申请日：2010-11-19

    申请人： KIREMIRE, Enos ,  UNIVERSITY OF NAMIBIA

    发明人： KIREMIRE, Enos

    IPC分类号： C07D213/53 ,  A61K33/24 ,  A61P33/06

    CPC分类号： C07F3/08 ,  C07D213/53

    摘要： Metal complex of Nickel (II) containing a dithio-based ligand have been synthesized and char¬ acterized by elemental analysis, mass spectrometry, Proton NMR and FT-IR spectrometry. A single crystal X-ray structure of the cadmium complex has been analyzed. The metal complex was subjected to biological tests on falcipain-2 (FP-2) and falcipain-3 (FP-3) cysteine protease enzymes from the malaria parasite Plasmodium falciparum. They were further tested in vitro against chloroquine resistant strain (W2). Whereas the potency of the metal complexes was weaker than the control regarding the FP-2 and FP-3, the potency of metal complexes was found to be exceedingly greater than the control when tested against the chloroquine resistant strain (W2) with a strength ratio of (1.4). This paper describes the synthesis, characterization and biological results of the said metal complex containing deprotonated 3-[l-(2-pyridyl) ethylidene] hydrazinecarbodithioate ligand (Fig. 1).

    摘要翻译： 已经通过元素分析，质谱，质子核磁共振和FT-IR光谱法合成了含有二硫基配体的镍（II）的金属络合物。 已经分析了镉络合物的单晶X射线结构。 对来自疟原虫恶性疟原虫的疟原虫-2（FP-2）和镰刀菌素-3（FP-3）半胱氨酸蛋白酶进行生物试验。 他们在体外进一步测试氯喹抗性菌株（W2）。 虽然金属络合物的效力弱于对FP-2和FP-3的对照，但是发现金属络合物的效力远高于对抗氯喹抗性菌株（W2）时的对照，强度比 （1.4）。 本文介绍了所述含有去质子化的3- [1-（2-吡啶基）亚乙基]肼碳二硫酸酯配体的金属络合物的合成，表征和生物学结果（图1）。

    PREPARATION OF GROUP II METAL ALKYLS
    5.
    发明申请
    PREPARATION OF GROUP II METAL ALKYLS 审中-公开
    第二组金属碱的制备

    公开(公告)号：WO1986006071A1

    公开(公告)日：1986-10-23

    申请号：PCT/GB1986000197

    申请日：1986-04-09

    申请人： THE SECRETARY OF STATE FOR DEFENCE IN HER ... ,  MULLIN, John, Brian ,  COLE-HAMILTON, David, John ,  ORRELL, Elisabeth, Diane ,  SHENAI-KHATKHATE, Deodatta, Vinayak ,  JACOBS, Philip, Reeve

    发明人： THE SECRETARY OF STATE FOR DEFENCE IN HER ...

    IPC分类号： C07F03/06

    CPC分类号： C07F3/08 ,  C07F3/06

    摘要： A method of preparing high purity dimethyl cadmium or dimethyl zinc suitable for use in the deposition of Group II-VI epitaxial layers, which consists of forming an adduct of the metal alkyl with a non-chelating tertiary amine containing at least two tertiary amino groups per amine molecule, and subsequently dissociating the adduct to liberate the metal alkyl as a vapour. The adducts formed during the preparative method are found to dissociate readily on heating and yet are substantially involatile and so do not contaminate the liberated metal alkyl. A preferred amine suitable for use in the preparative method is 4,4' bipyridyl.

    摘要翻译： 一种制备适合用于沉积II-VI族外延层的高纯度二甲基镉或二甲基锌的方法，其包括由金属烷基与含有至少两个叔氨基的非螯合叔胺形成加合物 胺分子，然后解离加合物以释放作为蒸气的金属烷基。 发现在制备方法期间形成的加合物在加热时容易解离，而且基本上是非挥发性的，因此不会污染释放的金属烷基。 适用于制备方法的优选胺是4,4'-联吡啶。

    TRISTHIOUREA TRIPODAL METAL COMPLEXES
    6.
    发明申请
    TRISTHIOUREA TRIPODAL METAL COMPLEXES 审中-公开
    三叉戟三元金属复合物

    公开(公告)号：WO2014126950A1

    公开(公告)日：2014-08-21

    申请号：PCT/US2014/015917

    申请日：2014-02-12

    申请人： SAAD, Fawaz ,  UMM AL-QURA UNIVERSITY ,  UMM AL-QURA GLOBAL PATENT TRUST

    发明人： SAAD, Fawaz

    IPC分类号： C07D401/14 ,  C07F13/00

    CPC分类号： C07F13/005 ,  C07D213/75 ,  C07F1/08 ,  C07F3/06 ,  C07F3/08 ,  C07F15/045 ,  C07F15/065

    摘要： The tristhiourea tripodal metal complexes are a group of coordination compounds having a transition metal linked by coordinate covalent bods to a chelating agent. The chelating agent has a tris-(6-amino-2-pyridylmethyl)amine (TAPA) backbone and three thiourea ligands bonded to the three legs of the TAPA backbone, respectively. The transition metal bonds to the amino groups of the TAPA backbone, and the thiourea ligands hydrogen bond to the anion guest remote from the transition metal. The chelating agent has a symmetrical C 3v tripodal cavity that is selective for tetrahedral anions. The transition metal is selected from the group consisting of cadmium, manganese, cobalt, nickel, copper, and zinc. The tristhiourea tripodal metal complexes may be used in colorimetric sensors, selectively permeable membranes, filtration media for separating tetrahedral anions (such as phosphate and perchlorate) from mixtures, and similar applications.

    摘要翻译： 三硫键三价金属络合物是一组具有通过配位共价骨架与螯合剂连接的过渡金属的配位化合物。 螯合剂分别具有三（6-氨基-2-吡啶基甲基）胺（TAPA）主链和三个硫脲配体键合到TAPA骨架的三条腿上。 过渡金属键合到TAPA主链的氨基上，而硫脲配体与过渡金属的阴离子客体键合氢键。 螯合剂具有对称的三价阴离子C3v三孔体，对四面体阴离子是选择性的。 过渡金属选自镉，锰，钴，镍，铜和锌。 三硝基三联体金属络合物可用于比色传感器，选择性渗透膜，用于从混合物中分离四面体阴离子（例如磷酸盐和高氯酸盐）的过滤介质和类似应用。