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    AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS
    1.
    发明申请
    AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS 审中-公开
    AZOARYLS作为可逆调节的TUBULIN抑制剂

    公开(公告)号：WO2015166295A1

    公开(公告)日：2015-11-05

    申请号：PCT/IB2014/001246

    申请日：2014-04-29

    Applicant: ECOLE NORMALE SUPERIEURE DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON I ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  LUDWIG-MAXIMILIANS-UNIVERSITÄT MUNCHEN

    Inventor： THORN-SESHOLD, Oliver ,  BOROWIAK, Malgorzata ,  TRAUNER, Dirk ,  HASSERODT, Jens

    IPC: C09B29/01 ,  A61K41/00 ,  C09B29/08

    CPC classification number: C09B29/12 ,  A61K41/0042 ,  C09B29/0003 ,  C09B29/0014 ,  C09B29/0048 ,  C09B29/081 ,  C09B29/26 ,  G01N33/582

    Abstract: The invention concerns a new class of tubulin polymerisation inhibitors and their applications in research and medicine, notably in chemotherapy. The invention proposes new azoaryl derivatives of formula (I): as defined in Claim 1, which may be fully reversibly interconverted between non-tubulin-binding trans and tubulin-binding cis isomeric forms, either by irradiation or spontaneously. The invention also concerns compounds with a azoaryl structure for use in studying the cytoskeleton and/or its associated processes, or in the treatment of a disease for which a tubulin polymerisation inhibition activity has a beneficial effect, wherein the compound is administered to the cell, organism or patient in need of such treatment in the trans form of the diazenyl bond, and where this trans form is inactive as regards a tubulin polymerisation inhibition effect, and where after photoisomerisation in vitro, in cellulo or in vivo to an azoaryl compound in its cis isomeric form of the diazenyl bond by the application of light, optionally with modification in vitro, in cellulo or in vivo of one or more substituents, the resultant cis form is active as regards a tubulin polymerisation inhibition effect.

    Abstract translation: 本发明涉及一类新型的微管蛋白聚合抑制剂及其在研究和医学中的应用，特别是化疗。 本发明提出了式（I）的新的偶氮芳基衍生物：如权利要求1所定义，其可以通过照射或自发地完全可逆地相互转化在非微管蛋白结合反式和微管蛋白结合的顺式异构体形式之间。 本发明还涉及具有用于研究细胞骨架和/或其相关过程的偶氮芳基结构的化合物，或者治疗其中微管蛋白聚合抑制活性具有有益效果的疾病，其中该化合物被施用于细胞， 关于微管蛋白聚合抑制作用，并且其中在反式形式在微管蛋白聚合抑制作用方面是无活性的，并且其中在体外，在纤维素中或体内将其转化成其中的偶氮芳基化合物 通过在纤维素或体内一个或多个取代基的应用光，任选地在体外进行修饰，所述顺式形式对于微管蛋白聚合抑制作用是有活性的，所述顺式异构体形式为二氮烯基键。

    ANTIBACTERIAL ACID DYES CONTAINING SILVER AND METHOD OF PREPARING THE SAME AND ANTIBACTERIAL FIBER THEREBY
    3.
    发明申请
    ANTIBACTERIAL ACID DYES CONTAINING SILVER AND METHOD OF PREPARING THE SAME AND ANTIBACTERIAL FIBER THEREBY 审中-公开
    含有银的防酸果皮及其制备方法及抗菌纤维

    公开(公告)号：WO2006091022A1

    公开(公告)日：2006-08-31

    申请号：PCT/KR2006/000622

    申请日：2006-02-23

    Applicant: KOLON INDUSTRIES, INC ,  PARK, Sung-Hui

    Inventor： PARK, Sung-Hui

    IPC: C09B29/24 ,  C09B29/01

    CPC classification number: C09B29/0803 ,  A01N59/16 ,  C09B29/0836 ,  C09B29/26 ,  D06M16/00 ,  D06P1/10

    Abstract: Disclosed are an anti-bacterial acid dye containing silver which is prepared by combining a sulfonamide based anti-bacterial agent containing silver as a strong anti-bacterial reactant group with any of intermediates of dyes and a preparation method thereof. The inventive anti-bacterial acid dye containing silver which has yellow color can express a wide range of colors when two or more of the dyes are used in combination. If a fiber is dyed using the anti-bacterial acid dye containing silver according to the present invention, it enables production of an anti-bacterially functional fiber product that exhibits strong anti-bacterial properties to inhibit inhabitation or growth of microorganisms and, as a result, protects against contagious disease and bad odor and prevents staining and brittleness of fiber of the product.

    Abstract translation: 公开了含有银的抗细菌酸性染料，其通过将含有银作为强抗菌反应物基团的磺酰胺类抗菌剂与任何染料中间体组合而制备，及其制备方法。 本发明的含有黄色的银的抗菌酸性染料可以在组合使用两种或更多种染料时表现出广泛的颜色。 如果使用根据本发明的含有银的抗菌酸性染料对纤维进行染色，则能够生产具有强抗菌性能的抗细菌功能纤维产品，以抑制微生物的生长或生长，结果 防止传染性疾病和恶臭，防止产品纤维的染色和脆性。

    CHROMOGENIC REAGENTS
    6.
    发明申请
    CHROMOGENIC REAGENTS 审中-公开
    染色剂

    公开(公告)号：WO1994004539A1

    公开(公告)日：1994-03-03

    申请号：PCT/GB1993001713

    申请日：1993-08-12

    Applicant: THE UNIVERSITY OF LIVERPOOL ,  SUTHERLAND, Ian, Oxley ,  SHOLL, Alastair, Foyle ,  SANDANAYAKE, Kaththota, Ralalage, Arunasiri, ...

    Inventor： THE UNIVERSITY OF LIVERPOOL

    IPC: C07D498/08

    CPC classification number: C07D498/08 ,  C09B29/26 ,  G01N31/22

    Abstract: Chromogenic reagents, and more particularly compounds which function as selective cation-sensitive dyes are disclosed. The compounds are of formula (II) wherein X is a chromophore; Y and Z are -CH2(CHR-O-CHR)nCH2- in which n is an integer from 1 - 10 (which may be different for Y and Z) and each R independently is hydrogen or a substituent for hydrogen or when n is an integer from 2-10 at least one -CHR-CHR- group may additionally represent a substituted or unsubstituted arylene group; W indicates one or more optional substituents on the benzene ring; and A is a group imparting acidity to the molecule. Preferred compounds are those in which n = 2 for Z and n = 1 or 2 for Y; X is 4-nitrophenylazophenol and R is hydrogen or additionally when n is 2 at least one -CHR-CHR- group may represent a substituted or unsubstituted arylene group.

    Abstract translation: 公开了显色剂，更特别是用作选择性阳离子敏感染料的化合物。 所述化合物具有式（II），其中X是发色团; Y和Z是-CH 2（CHR-O-CHR）nCH 2 - ，其中n是1-10的整数（对于Y和Z可以是不同的），每个R独立地是氢或氢的取代基，或者当n是 2-10的整数，至少一个-CHR-CHR-基团可另外表示取代或未取代的亚芳基; W表示苯环上一个或多个任选的取代基; 而A是赋予该分子酸性的基团。 优选的化合物是对于Z为n = 2且对于Y为n = 1或2的化合物; X是4-硝基苯基偶氮苯酚，R是氢或另外当n是2时，至少一个-CHR-CHR-基团可以代表取代或未取代的亚芳基。

    AZO DYES, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF
    7.
    发明申请
    AZO DYES, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF 审中-公开
    AZO染料，其制备方法及其用途

    公开(公告)号：WO2010046192A2

    公开(公告)日：2010-04-29

    申请号：PCT/EP2009062300

    申请日：2009-09-23

    Applicant: HUNTSMAN ADV MAT SWITZERLAND ,  PETERMANN RALF ,  SUPPIGER CHRISTIAN ,  LAUK URS

    Inventor： PETERMANN RALF ,  SUPPIGER CHRISTIAN ,  LAUK URS

    IPC: C09B29/00

    CPC classification number: C09B29/0003 ,  C09B29/0033 ,  C09B29/0059 ,  C09B29/0081 ,  C09B29/0085 ,  C09B29/081 ,  C09B29/0811 ,  C09B29/0833 ,  C09B29/24 ,  C09B29/26 ,  Y10S8/92

    Abstract: The present invention relates to dyes of formula (I) wherein R1 and R2 are each independently of the other hydrogen, vinyl, allyl or C1-C6alkyl which is unsubstituted or substituted by cyano, carboxy, hydroxy, C1-C6alkoxy or C6-C24aryl, R3 is hydrogen, C1-C6alkyl or C6-C24aryl, R4 is hydrogen, C1-C6alkyl or C6-C24aryl, 2-Cyano-C1-C6alkyl, 2-Alkoxy-C1-C6alkyl, 2-Oxo-C1-C6alkyl, n is 0, 1 or 2, and D denotes a radical of formula (2), (3), (4), (5), (6) or (7) wherein R5 is hydrogen, nitro, cyano or halogen, R6 and R7 are each independently of the other hydrogen, nitro, cyano or halogen, R8 and R9 are each independently of the other hydrogen, nitro, cyano or halogen, R10 and R11 are each independently of the other nitro, cyano, trifluoromethyl, carboxy, C1-C6alkyl, C1-C6alkoxy, C1-C6acylamino or halogen, R12 and R13 are each independently of the other hydrogen, nitro, cyano, trifluoromethyl, carboxy, C1-C6alkoxycarbonyl, C1-C6alkylsulfonyl, C1-C6alkylsulfonylamino, C1-C6acylamino or halogen, R14 represents nitro, cyano or halogen and R15 is C1-C6alkyl, and R16 is nitro, cyano, trifluoromethyl, carboxy, C1-C6alkylsulfonyl, C1-C6alkylsulfonylamino, C1-C6acylamino or halogen, and to the process for the preparation thereof and to the use thereof in dyeing or printing semi-synthetic and especially synthetic hydrophobic fibre materials, more especially textile materials.

    Abstract translation: 本发明涉及式（I）的染料，其中R 1和R 2各自独立地为未被取代或被氰基，羧基，羟基，C 1 -C 6烷氧基或C 6 -C 24芳基取​​代的其它氢，乙烯基，烯丙基或C 1 -C 6烷基， R3是氢，C1-C6烷基或C6-C24芳基，R4是氢，C1-C6烷基或C6-C24芳基，2-氰基-C1-C6烷基，2-烷氧基-C1-C6烷基，2-氧代-C1-C6烷基， （2），（3），（4），（5），（6）或（7）的基团，其中R5是氢，硝基，氰基或卤素，R6和R7 各自独立为氢，硝基，氰基或卤素，R 8和R 9各自独立地为氢，硝基，氰基或卤素，R 10和R 11各自独立地为其他硝基，氰基，三氟甲基，羧基，C1- C6烷基，C1-C6烷氧基，C1-C6烷氨基或卤素，R12和R13各自独立地为氢，硝基，氰基，三氟甲基，羧基，C1-C6烷氧基羰基，C1-C6烷基磺酰基，C1-6烷基磺酰基氨基， R14代表硝基，氰基或卤素，R15代表C1-C6烷基，R16代表硝基，氰基，三氟甲基，羧基，C1-C6烷基磺酰基，C1-C6烷基磺酰氨基，C1-C6酰氨基或卤素，和其制备方法和 涉及其在染色或印刷半合成和特别合成的疏水性纤维材料，尤其是纺织材料中的用途。

    アゾ色素
    8.
    发明申请
    アゾ色素 审中-公开
    AZO DYE

    公开(公告)号：WO2006004134A1

    公开(公告)日：2006-01-12

    申请号：PCT/JP2005/012431

    申请日：2005-06-29

    Applicant: 富士写真フイルム株式会社 ,  石綿 靖宏

    Inventor： 石綿 靖宏

    IPC: C09B29/12

    CPC classification number: C09B29/0081 ,  C07D513/04 ,  C09B29/12 ,  C09B29/26

    Abstract: 下記一般式（I）で表わされるアゾ色素。　一般式（I）　一般式（Ｉ）において、Ｒ １ 、Ｒ ２ 、Ｒ ３ 及びＲ ４ は、各々独立して水素原子、脂肪族基、アリール基、ハロゲン原子、アシル基、シアノ基、アシルアミノ基、脂肪族オキシカルボニル基、アリールオキシカルボニル基、カルバモイル基、脂肪族スルホニル基、アリールスルホニル基、スルファモイル基、脂肪族オキシカルボニルアミノ基、アリールオキシカルボニルアミノ基、スルホ基、カルボキシル基、カルバモイルアミノ基、スルファモイルアミノ基、又は脂肪族もしくは芳香族スルホニルアミノ基を表す。Ｒ １ とＲ ２ および／またはＲ ３ とＲ ４ は結合し５または６員の芳香環あるいは非芳香環を形成してもよい。Ｘは炭素原子または窒素原子を表し、Ｘが窒素原子のときｎは０であり、炭素原子のときｎは１である。Ａ、Ｂ、Ｃ及びＤは炭素原子または窒素原子を表し、Ａ、Ｂ、Ｃ及びＤの少なくとも１個は窒素原子を表す。Ｙは置換基を表し、ｍは０から３の整数を表す。

    Abstract translation: 公开了由以下通式（I）表示的偶氮染料。 在通式（I）中，R 1，R 2，R 3和R 4独立地表示 氢原子，脂族基团，芳基，卤素原子，酰基，氰基，酰基氨基，脂族氧基羰基，芳氧基羰基，氨基甲酰基，脂肪族磺酰基，芳基磺酰基， 氨磺酰基，脂族氧羰基氨基，芳氧基羰基氨基，磺基，羧基，氨基甲酰氨基，氨磺酰氨基或脂族或芳族磺酰氨基。 R 1和R 2和/或R 3和R 4可以结合在一起形成五元环 或六元芳族或非芳族环。 X表示碳原子或氮原子，当X为氮原子时n为0，而当X为碳原子时n为1。 A，B，C和D分别表示碳原子或氮原子，A，B，C和D中的至少一个表示氮原子。 Y表示取代基，m表示0〜3的整数。

    PROCESS FOR DETECTING MARKED MINERAL OILS AND NEW AZO DYES
    9.
    发明申请
    PROCESS FOR DETECTING MARKED MINERAL OILS AND NEW AZO DYES 审中-公开
    检测方法的标明矿物油和新的偶氮染料

    公开(公告)号：WO1995010581A1

    公开(公告)日：1995-04-20

    申请号：PCT/EP1994003259

    申请日：1994-09-30

    Applicant: BASF AKTIENGESELLSCHAFT

    Inventor： BASF AKTIENGESELLSCHAFT ,  DYLLICK-BRENZINGER, Rainer ,  RAULFS, Friedrich-Wilhelm ,  SCHLÖSSER, Ulrike ,  BECK, Karin, Heidrun ,  SCHOLZ, Gerhard

    IPC: C10L01/00

    CPC classification number: C09B29/12 ,  C09B29/26 ,  C09B31/062 ,  C10L1/003 ,  C10L1/226 ,  C10M171/007 ,  G01N33/2882

    Abstract: A process for detecting marked mineral oils by treating the marked mineral oil with an extracting agent containing water, a solvent and a base, in which use is made as the marking agent of an azo dye of formula (I), in which ring A may be benzo-anellated and l is 1 or 2, m is 1 to 4, X is hydrogen, C1-C4-alkyl, cyano, nitro or possibly substituted phenylazo; X is hydrogen, C1-C4-alkyl, cyano, nitro, C1-C4-alkoxy or C1-C16-alkoxy carbonyl; X is hydrogen, C1-C4-alkyl, cyano or C1-C16-alkoxy carbonyl and X is hydrogen, hydroxy, possibly substituted C1-C8-alkyl, C1-C4-alkoxy, amino, C1-C4-dialkyl amino or possibly substituted C1-C16-monoalkylamino. A partially or completely water-miscible organic solvent is used as the solvent and the base is an alkaline or alkaline earth hydroxide, an alkali carbonate or a quaternary ammonium hydroxide. The invention also relates to the use of azo dyes as marking agents for mineral oils and novel azo dyes.

    Abstract translation: 通过用萃取剂包括水，溶剂和碱处理所标记的矿物油，使用作为标记的式（I）的偶氮染料，其中环A可以被苯并稠合和升1或2所述的检测标记的矿物油的方法， m为1〜4，X <1>为氢，C1-C4烷基，氰基，硝基或任选取代的苯偶氮基，X <2>为氢，C1-C4烷基，氰基，硝基，C1-C4烷氧基或C1-C16 烷氧基羰基，X <3>为氢，C1-C4烷基，氰基，或C1-C16烷氧羰基，且X <4>是氢，羟基，任选取代的C1-C8烷基，C1-C4烷氧基，氨基，C1-C4 意味着二烷基氨基，或任选取代的C1-C16-单烷基氨基，作为溶剂中的部分或完全与水混溶的有机溶剂和作为碱的碱金属或碱土金属氢氧化物，碱金属碳酸盐或氢氧化季铵，使用偶氮染料作为Markierungsmit的 电话为矿物油和新颖偶氮染料。

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