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    ANTISENSE COMPOUNDS AND USES THEREOF
    1.
    发明申请
    ANTISENSE COMPOUNDS AND USES THEREOF 审中-公开
    抗体化合物及其用途

    公开(公告)号：WO2016061263A1

    公开(公告)日：2016-04-21

    申请号：PCT/US2015/055582

    申请日：2015-10-14

    Applicant: IONIS PHARMACEUTICALS, INC. ,  COLD SPRING HARBOR LABORATORY

    Inventor： RIGO, Frank ,  KRAINER, Adrian, R.

    IPC: G01N33/68

    CPC classification number: C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2310/346 ,  C12N2320/31 ,  C12N2320/33 ,  C12Y207/0104 ,  C12N2310/321 ,  C12N2310/3525

    Abstract: The present invention provides compounds comprising oligonucleotides complementary to a pyruvate kinase M transcript. Certain such compounds are useful for hybridizing to a pyruvate kinase M transcript, including but not limited to a pyruvate kinase M transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the pyruvate kinase M transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with cancer.

    Abstract translation: 本发明提供了包含与丙酮酸激酶M转录物互补的寡核苷酸的化合物。 某些这样的化合物可用于与丙酮酸激酶M转录物杂交，包括但不限于细胞中的丙酮酸激酶M转录物。 在某些实施方案中，这种杂交导致丙酮酸激酶M转录物剪接的调节。 在某些实施方案中，这些化合物用于治疗与癌症相关的一种或多种症状。

    ANTISENSE COMPOUNDS AND USES THEREOF
    7.
    发明申请
    ANTISENSE COMPOUNDS AND USES THEREOF 审中-公开
    抗体化合物及其用途

    公开(公告)号：WO2014071078A1

    公开(公告)日：2014-05-08

    申请号：PCT/US2013/067881

    申请日：2013-10-31

    Applicant: ISIS PHARMACEUTICALS, INC. ,  COLD SPRING HARBOR LABORATORY

    Inventor： RIGO, Frank ,  BENNETT, C., Frank ,  KRAINER, Adrian, R. ,  WANG, Zhenxun

    IPC: C12N15/113

    CPC classification number: C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12Y207/0104

    Abstract: The present invention provides compounds comprising oligonucleotides complementary to a pyruvate kinase M transcript. Certain such compounds are useful for hybridizing to a pyruvate kinase M transcript, including but not limited to a pyruvate kinase M transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the pyruvate kinase M transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with cancer.

    Abstract translation: 本发明提供了包含与丙酮酸激酶M转录物互补的寡核苷酸的化合物。 某些这样的化合物可用于与丙酮酸激酶M转录物杂交，包括但不限于细胞中的丙酮酸激酶M转录物。 在某些实施方案中，这种杂交导致丙酮酸激酶M转录物剪接的调节。 在某些实施方案中，这些化合物用于治疗与癌症相关的一种或多种症状。

    NUCLEIC ACID CODING FOR A BONDING SITE OF A PROTEIN KINASE OF THE MITOGENIC SIGNALLING CASCADE OF A GLYCOLYSIS-CATALYSING ENZYME
    8.
    发明申请
    NUCLEIC ACID CODING FOR A BONDING SITE OF A PROTEIN KINASE OF THE MITOGENIC SIGNALLING CASCADE OF A GLYCOLYSIS-CATALYSING ENZYME 审中-公开
    核酸，其编码蛋白激酶的有丝分裂信号传导级联的结合位点糖酵解酶催化

    公开(公告)号：WO01096535A2

    公开(公告)日：2001-12-20

    申请号：PCT/DE2001/002246

    申请日：2001-06-14

    IPC: A61K38/00 ,  C12N9/12 ,  C12N15/54 ,  C12N9/00

    CPC classification number: C12N9/1205 ,  A61K38/00 ,  C12Y207/0104

    Abstract: The invention relates to a nucleic acid coding for at least one partial sequence of a protein kinase of the mitogenic signalling cascade, whereby the partial sequence codes for a binding site for a glycolysis-catalysing enzyme. The invention further relates to a silent mutation of one such nucleic acid or a nucleic acid hybridising with one such nucleic acid or the silent mutation thereof.

    Abstract translation: 本发明教导了一种核酸编码至少所述有丝分裂信号级联的蛋白激酶的部分序列，其中所述亚序列编码糖酵解酶催化，或这样的核酸的沉默突变的结合位点，或与这样的核酸或它的沉默突变杂交的核酸。

    NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY
    9.
    发明申请
    NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY 审中-公开
    具有改善能源效率的非天然微生物有机体

    公开(公告)号：WO2016044713A1

    公开(公告)日：2016-03-24

    申请号：PCT/US2015/050923

    申请日：2015-09-18

    Applicant: GENOMATICA, INC.

    Inventor： PHARKYA, Priti ,  BURGARD, Anthony P. ,  NUNEZ VAN NAME, Eric Roland

    IPC: C12P7/42 ,  C12P7/16

    CPC classification number: C12N15/52 ,  C12N9/1205 ,  C12N9/88 ,  C12P5/026 ,  C12P7/04 ,  C12P7/18 ,  C12P7/40 ,  C12P7/42 ,  C12Y207/0104 ,  C12Y401/02009 ,  C12Y401/02022 ,  Y02E50/343

    Abstract: The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA, or oxaloacetate and acetyl-CoA. Embodiments of the invention include microbial organisms having a pathway to acetyl-CoA and oxaloacetate that includes phosphoketolase (a PK pathway). The organisms also have either (i) a genetic modification that enhances the activity of the non-phosphotransferase system (non-PTS) for sugar uptake, and/or (ii) a genetic modification(s) to the organism's electron transport chain (ETC) that enhances efficiency of ATP production, that enhances availability of reducing equivalents or both. The microbial organisms can optionally include (iii) a genetic modification that maintains, attenuates, or eliminates the activity of a phosphotransferase system (PTS) for sugar uptake. The enhanced carbon flux through acetyl-CoA and oxaloacetate can be used for production of a bioderived compound, and the microbial organisms can further include a pathway capable of producing the bioderived compound.

    Abstract translation: 本发明提供了含有酶途径和/或代谢修饰用于增强通过乙酰辅酶A，或草酰乙酸和乙酰辅酶A的碳通量的非天然微生物生物。 本发明的实施方案包括具有乙酰辅酶A途径和包含磷酸酮醇酶（PK途径）的草酰乙酸的途径的微生物。 生物体还具有（i）增强非磷酸转移酶系统（非PTS）对于糖吸收的活性的遗传修饰，和/或（ii）对生物体的电子传递链（ETC）的遗传修饰 ），其提高了ATP生产的效率，这增强了减少等效物或两者的可用性。 微生物生物可以任选地包括（iii）维持，减弱或消除磷酸转移酶系统（PTS）用于糖摄取的活性的遗传修饰。 通过乙酰辅酶A和草酰乙酸酯的增强的碳通量可用于生产生物活性化合物，并且微生物有机体可以进一步包括能够生产生物活性化合物的途径。

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