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    COENZYMES USEFUL FOR THE SYNTHESIS OF L-CARNITINE
    4.
    发明申请
    COENZYMES USEFUL FOR THE SYNTHESIS OF L-CARNITINE 审中-公开
    聚合物可用于合成L-卡尼汀

    公开(公告)号：WO00024919A1

    公开(公告)日：2000-05-04

    申请号：PCT/IT1999/000339

    申请日：1999-10-22

    IPC: C07B53/00 ,  C07B61/00 ,  C07C227/16 ,  C07C227/32 ,  C07C229/06 ,  C07G99/00 ,  C07H19/20 ,  C12P13/00 ,  C12P41/00

    CPC classification number: C07H19/20 ,  C12P13/007 ,  C12P41/001

    Abstract: The invention described herein relates to coenzymes useful for the synthesis of L-carnitine, particularly a compound of coenzyme A, and more particularly gamma-butyrobetainyl-coenzyme A and crotonobetainyl-coenzyme A, to procedures for their preparation and to their use for the production of L(-)-carnitine from crotonobetaine and D(-)-carnitine.

    Abstract translation: 本文所述的发明涉及可用于合成L-肉毒碱，特别是辅酶A的化合物的更适合于γ-丁酰谷维酮酰辅酶A和巴豆甜菜碱 - 辅酶A的辅酶，其制备方法及其用于生产 的（ - ） - 肉碱从巴豆甜菜碱和D（ - ） - 肉碱。

    PROCESS AND COMPOSITION FOR PREPARING D-ASPARTIC ACID
    5.
    发明申请
    PROCESS AND COMPOSITION FOR PREPARING D-ASPARTIC ACID 审中-公开
    制备D-天冬氨酸的方法和组合物

    公开(公告)号：WO1998018954A1

    公开(公告)日：1998-05-07

    申请号：PCT/US1997019371

    申请日：1997-10-28

    Applicant: MONSANTO COMPANY

    Inventor： MONSANTO COMPANY ,  PANTALEONE, David, P. ,  FOTHERINGHAM, Ian, G. ,  TON, Jennifer, L.

    IPC: C12P41/00

    CPC classification number: C12P41/001 ,  C12P13/06 ,  C12P13/20

    Abstract: A process and composition for preparing D-aspartic acid and beta -alanine from D,L-aspartic acid, wherein a solution of D,L-aspartic acid or a salt thereof is contacted with a composition having an L-aspartate- alpha -decarboxylase activity of greater than 100 mu mol L-aspartate used per hour per gram of cells, under appropriate conditions to produce D-aspartic acid and beta -alanine.

    Abstract translation: 从D，L-天冬氨酸制备D-天冬氨酸和β-丙氨酸的方法和组合物，其中D，L-天冬氨酸或其盐的溶液与具有L-天冬氨酸-α-脱羧酶的组合物接触 在适当条件下，每小时每克细胞使用大于100微摩尔L-天冬氨酸的活性，以产生D-天冬氨酸和β-丙氨酸。

    A NOVEL BACTERIAL STRAIN OF ACHROMOBACTER SP. MTCC 5605 AND A HIGHLY ENANTIOSELECTIVE EPOXIDE HYDROLASE ISOLATED THEREFROM
    6.
    发明申请
    A NOVEL BACTERIAL STRAIN OF ACHROMOBACTER SP. MTCC 5605 AND A HIGHLY ENANTIOSELECTIVE EPOXIDE HYDROLASE ISOLATED THEREFROM 审中-公开
    ACHROMOBACTER SP的新型细菌菌株 MTCC 5605和分离的高选择性环氧化物水解剂

    公开(公告)号：WO2013030851A4

    公开(公告)日：2013-05-10

    申请号：PCT/IN2012000569

    申请日：2012-08-27

    Applicant: COUNCIL OF SCIENT & INDUSTRAIL RES ,  KAMAL AHMED ,  KHANNA ROHINI ,  KUMAR CHITYAL GANESH ,  SHAIK ANVER BASHA ,  KUMAR MATAM SHIVA

    Inventor： KAMAL AHMED ,  KHANNA ROHINI ,  KUMAR CHITYAL GANESH ,  SHAIK ANVER BASHA ,  KUMAR MATAM SHIVA

    IPC: C12N1/20 ,  C12N1/26 ,  C12N9/14 ,  C12P41/00 ,  C12R1/025

    CPC classification number: C12N9/14 ,  C12P7/18 ,  C12P41/001 ,  C12R1/025 ,  C12Y303/02003

    Abstract: The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invention further relates to a new bacterial strain Achromobacter sp. MTCC 5605 isolated from a petroleum-contaminated sludge sample, capable of producing the said enzyme. It is notable that the enzyme can be used as whole bacterial cell preparation, which allows continuous hydrolysis of substrates at even higher concentration and have an advantage of being recycled. The invention further relates to a process for the hydrolysis of different aryl epoxides which are potential synthons of intermediates for the synthesis of chiral amino alcohols and bioactive compounds like beta-blockers.

    Abstract translation: 本发明涉及一种新的环氧化物水解酶，其目的是为具有高对映选择性的较宽范围的底物获得高度的分辨率，并以最小的产物抑制率得到产率。 本发明还涉及一种新的细菌菌株Achromobacter sp。 从能够产生所述酶的经石油污染的污泥样品中分离出的MTCC 5605。 值得注意的是，该酶可以用作整个细菌细胞制剂，其允许以更高浓度连续水解底物并且具有被回收的优点。 本发明还涉及水解不同芳基环氧化物的方法，它们是用于合成手性氨基醇和生物活性化合物如β-阻滞剂的中间体的潜在合成子。

    R-HNL RANDOM VARIANTS AND THEIR USE FOR PREPARING OPTICALLY PURE, STERICALLY HINDERED CYANOHYDRINS
    7.
    发明申请
    R-HNL RANDOM VARIANTS AND THEIR USE FOR PREPARING OPTICALLY PURE, STERICALLY HINDERED CYANOHYDRINS 审中-公开
    R-HNL随机变量及其用于制备光学纯的，异味的氰基氰

    公开(公告)号：WO2008071695A1

    公开(公告)日：2008-06-19

    申请号：PCT/EP2007/063692

    申请日：2007-12-11

    Applicant: DSM IP ASSETS BV ,  GLIEDER, Anton

    Inventor： GLIEDER, Anton

    IPC: C12N9/88 ,  C12P13/00 ,  C12P41/00

    CPC classification number: C12N9/88 ,  C12P13/004 ,  C12P41/001

    Abstract: The invention relates to R -hydroxynitrile lyases with improved substrate acceptance, increased activity and increased selectivity, obtainable by introducing random mutations with the aid of random mutagenesis and/or saturation mutagenesis techniques, identifyingby means of screening or selection and, where appropriate, subsequently combining advantageous mutations, and to the use thereof.

    Abstract translation: 本发明涉及具有改善的底物接受性，增加的活性和增加的选择性的R-羟基腈裂解酶，其可通过借助于随机诱变和/或饱和诱变技术引入随机突变而获得，通过筛选或选择鉴定，并且在适当的情况下随后组合 有利的突变及其用途。

    PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED NITRILES
    8.
    发明申请
    PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED NITRILES 审中-公开
    制备充分增强的硝酸盐的方法

    公开(公告)号：WO2007128469A1

    公开(公告)日：2007-11-15

    申请号：PCT/EP2007/003852

    申请日：2007-05-02

    Applicant: DSM IP ASSETS B.V. ,  MINK, Daniel ,  LUTJE SPELBERG, Jeffrey, Harald ,  VRIES,DE, Erik Jan

    Inventor： MINK, Daniel ,  LUTJE SPELBERG, Jeffrey, Harald ,  VRIES,DE, Erik Jan

    IPC: C12P13/00 ,  C12P41/00 ,  C12P17/02 ,  C12P17/10 ,  C12P17/12

    CPC classification number: C12P13/002 ,  C12P17/02 ,  C12P17/10 ,  C12P17/12 ,  C12P41/001 ,  C12P41/006

    Abstract: The invention relates to a process for the preparation of an enantiomerically enriched nitrile by reacting an epihalohydrin (derivative) with Br - and CN - in the presence of an enantioselective haloalcohol dehalogenase. The process of the invention leads to enantiomerically enriched nitriles in a high yield and in a high enantiomeric excess. Preferably the haloalcohol dehalogenase used is HheC, more preferably HheC from Agrobacterium radiobacter AD1, most preferably the W249F mutant from HheC from Agrobacterium radiobacter AD1. In one preferred embodiment of the invention the epihalohydrin (derivative) is epichlorohydrin. The enantiomerically enriched nitriles obtained by the process of the invention are especially suitable as intermediates in the preparation of statins, in particular of atorvastatin or rosuvastatin.

    Abstract translation: 本发明涉及一种通过在对映选择性卤代醇脱卤酶存在下使表卤代醇（衍生物）与Br - 和/或SUP反应来制备对映体富集的腈的方法。 本发明的方法以高产率和高对映体过量导致对映体富集的腈。 优选使用的卤代醇脱卤酶是HheC，更优选来自放射性土壤杆菌AD1的HheC，最优选来自放射性土壤杆菌AD1的来自HheC的W249F突变体。 在本发明的一个优选实施方案中，表卤代醇（衍生物）是表氯醇。 通过本发明方法获得的对映异构体富集的腈特别适合作为他汀类药物，特别是阿托伐他汀或罗苏伐他汀制剂的中间体。

    PROCESS FOR THE PRODUCTION OF ENZYMES WITH ALTERED CATALYTIC ACTIVITY RELATIVE TO AN AMINO ACID SUBSTRATE AND ENZYMES SO PRODUCED
    10.
    发明申请
    PROCESS FOR THE PRODUCTION OF ENZYMES WITH ALTERED CATALYTIC ACTIVITY RELATIVE TO AN AMINO ACID SUBSTRATE AND ENZYMES SO PRODUCED 审中-公开
    生产具有相对于氨基酸底物和生产的酶的催化活性的酶的方法

    公开(公告)号：WO00037631A1

    公开(公告)日：2000-06-29

    申请号：PCT/IE1998/000113

    申请日：1998-12-22

    IPC: C12N9/10 ,  C12N15/01 ,  C12P13/04 ,  C12P41/00 ,  C12N1/20

    CPC classification number: C12N15/01 ,  C12N9/1096 ,  C12P13/04 ,  C12P41/001

    Abstract: A process for the production of an altered microbial enzyme, especially an aminotransferase, which displays catalytic activity towards the L-enantiomer of an amino acid which is not the normal substrate for the precursor enzyme comprises treating a microorganism with a mutagenic agent, growing the microorganism so treated on a medium containing said amino acid as the sole nitrogen source and isolating surviving microorganisms containing enzymes capable of using said amino acid as a substrate. The process involves the use of a random chemical mutagen followed by a biological selection procedure and does not require prior knowledge of the protein structure of the enzyme nor site-directed mutagenesis.

    Abstract translation: 生产对于不是前体酶的正常底物的氨基酸的L-对映体显示催化活性的改变的微生物酶，特别是氨基转移酶的方法包括用致突变剂处理微生物，培养微生物 在包含所述氨基酸作为唯一氮源的培养基上进行处理，并分离含有能够使用所述氨基酸作为底物的酶的存活微生物。 该方法包括使用随机化学诱变剂，然后使用生物选择程序，并且不需要酶的蛋白质结构的先前知识或定点诱变。

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