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    트랜스아미나제의 조기질 순환을 이용한 광학 활성 아미노산의 제조방법
    2.
    发明申请
    트랜스아미나제의 조기질 순환을 이용한 광학 활성 아미노산의 제조방법 审中-公开
    通过使用跨膜酶的矩阵循环制备光学活性氨基酸的方法

    公开(公告)号：WO2014007588A1

    公开(公告)日：2014-01-09

    申请号：PCT/KR2013/006028

    申请日：2013-07-08

    Applicant: 연세대학교 산학협력단

    Inventor： 신종식 ,  박을수

    IPC: C12P13/06 ,  C12P13/08 ,  C12N9/10 ,  C12N9/78

    CPC classification number: C12P13/14 ,  C12N9/1096 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/12 ,  C12P13/20 ,  C12P13/222 ,  C12Y206/01018 ,  C12Y206/01042 ,  Y02P20/52

    Abstract: 본 발명은 트랜스아미나제의 조기질 순환을 이용한 광학 활성 아미노산을 제조하는 방법에 관한 것으로서, 알파 트랜스아미나제에 의해서 케토산을 아미노산으로 전환시키는 반응과, 오메가 트랜스아미나제에 의해서 아민 기질의 아민을 전이시키는 반응을 아미노산 조기질에 의해서 커플링시켜 순환 반응시키는 것을 특징으로 하며, 본 발명은 종래 트랜스아미나제의 낮은 반응 평형상수 문제를 해결하여 고순도의 다양한 광학 활성 아미노산을 고효율로 생산할 수 있어 다양한 아미노산의 생산 공정에 산업적으로 사용될 수 있다. 또한, 높은 반응성과 안정성을 가지는 본 발명에 의해서 제약 전구체로 사용되는 다양한 비천연 아미노산을 손쉽게 생산할 수 있어 제약, 식품 첨가물, 각종 동물 사료 제조 분야에서 활용할 수 있다.

    Abstract translation: 本发明涉及通过使用转氨酶的基质循环来制备光学活性氨基酸的方法，其中通过α-转氨酶将酮酸转化为氨基酸的反应和转移胺底物的胺的反应 由微米 - 转氨酶通过氨基酸基质偶联循环反应。 通过解决转氨酶的低反应平衡常数的已知问题，本发明可以高效率和高纯度地生产各种光学活性氨基酸，因此可以工业上用于生产各种氨基酸的方法。 此外，本发明可以容易地生产具有高反应性和稳定性的各种非天然氨基酸用作药物前体，因此氨基酸可以应用于医药，食品添加剂和各种动物饲料制造领域。

    COMPOSITIONS AND METHODS FOR ENHANCING THE DEGRADATION OR CONVERSION OF CELLULOSE-CONTAINING MATERIAL
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR ENHANCING THE DEGRADATION OR CONVERSION OF CELLULOSE-CONTAINING MATERIAL 审中-公开
    用于增强含有纤维素的材料的降解或转化的组合物和方法

    公开(公告)号：WO2008140749A3

    公开(公告)日：2009-01-15

    申请号：PCT/US2008005927

    申请日：2008-05-09

    Applicant: NOVOZYMES INC ,  MCFARLAND KEITH

    Inventor： MCFARLAND KEITH

    IPC: C12N9/42 ,  C12N1/14 ,  C12P7/06

    CPC classification number: C12P13/20 ,  C12N9/2437 ,  C12N9/2445 ,  C12P5/023 ,  C12P7/06 ,  C12P7/14 ,  C12P7/24 ,  C12P7/26 ,  C12P19/14 ,  C12P2201/00 ,  C12P2203/00 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16 ,  Y02E50/17 ,  Y02E50/343 ,  Y02P20/52

    Abstract: The present invention relates to methods for degrading or converting a cellulose-containing material, comprising: treating the cellulose-containing material with an effective amount of a cellulolytic enzyme composition comprising a polypeptide having cellulolytic enhancing activity, and one or more (several) components selected from the group consisting of a CEL7 polypeptide having endoglucanase activity, a CEL12 polypeptide having endoglucanase activity, a CEL45 polypeptide having endoglucanase activity, a CEL7 polypeptide having cellobiohydrolase activity with a cellulose binding domain, and a CEL7 polypeptide having cellobiohydrolase activity without a cellulose binding domain. The present invention also relates to such cellulolytic enzyme compositions.

    Abstract translation: 本发明涉及降解或转化含纤维素材料的方法，其包括：用有效量的包含具有纤维素分解增强活性的多肽的纤维素分解酶组合物和选择的一种或多种（若干）组分处理含纤维素材料 由具有内切葡聚糖酶活性的CEL7多肽，具有内切葡聚糖酶活性的CEL12多肽，具有内切葡聚糖酶活性的CEL45多肽，具有纤维素结合结构域的纤维二糖水解酶活性的CEL7多肽和不含纤维素结合结构域的纤维二糖水解酶活性的CEL7多肽 。 本发明还涉及这种纤维素分解酶组合物。

    COMPOSITIONS AND METHODS FOR ENHANCING THE DEGRADATION OR CONVERSION OF CELLULOSE-CONTAINING MATERIAL
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR ENHANCING THE DEGRADATION OR CONVERSION OF CELLULOSE-CONTAINING MATERIAL 审中-公开
    用于增强含有纤维素的材料的降解或转化的组合物和方法

    公开(公告)号：WO2008140749A2

    公开(公告)日：2008-11-20

    申请号：PCT/US2008/005927

    申请日：2008-05-09

    Applicant: NOVOZYMES, INC. ,  MCFARLAND, Keith

    Inventor： MCFARLAND, Keith

    IPC: C12N9/42 ,  C12P7/06 ,  C12N1/14

    CPC classification number: C12P13/20 ,  C12N9/2437 ,  C12N9/2445 ,  C12P5/023 ,  C12P7/06 ,  C12P7/14 ,  C12P7/24 ,  C12P7/26 ,  C12P19/14 ,  C12P2201/00 ,  C12P2203/00 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16 ,  Y02E50/17 ,  Y02E50/343 ,  Y02P20/52

    Abstract: The present invention relates to methods for degrading or converting a cellulose-containing material, comprising: treating the cellulose-containing material with an effective amount of a cellulolytic enzyme composition comprising a polypeptide having cellulolytic enhancing activity, and one or more (several) components selected from the group consisting of a CEL7 polypeptide having endoglucanase activity, a CEL12 polypeptide having endoglucanase activity, a CEL45 polypeptide having endoglucanase activity, a CEL7 polypeptide having cellobiohydrolase activity with a cellulose binding domain, and a CEL7 polypeptide having cellobiohydrolase activity without a cellulose binding domain. The present invention also relates to such cellulolytic enzyme compositions.

    Abstract translation: 本发明涉及降解或转化含纤维素材料的方法，其包括：用有效量的包含具有纤维素分解增强活性的多肽的纤维素分解酶组合物和选择一种或多种（若干）组分来处理含纤维素材料 由具有内切葡聚糖酶活性的CEL7多肽，具有内切葡聚糖酶活性的CEL12多肽，具有内切葡聚糖酶活性的CEL45多肽，具有纤维素结合结构域的纤维二糖水解酶活性的CEL7多肽和不含纤维素结合结构域的纤维二糖水解酶活性的CEL7多肽组成的组 。 本发明还涉及这种纤维素分解酶组合物。

    GENES FROM ACTINOBACILLUS SUCCINOGENES 13OZ (ATCC 55618) FOR PRODUCTION OF CHEMICALS FROM THE A. SUCCINOGENES C4-PATHWAY
    6.
    发明申请
    GENES FROM ACTINOBACILLUS SUCCINOGENES 13OZ (ATCC 55618) FOR PRODUCTION OF CHEMICALS FROM THE A. SUCCINOGENES C4-PATHWAY 审中-公开
    来自ACTINOBACILLUS SUCCINOGENES 13OZ的基因（ATCC 55618）用于从A.SCCC生产C4途径中的化学物质

    公开(公告)号：WO2007019301A3

    公开(公告)日：2007-07-12

    申请号：PCT/US2006030425

    申请日：2006-08-04

    Applicant: UNIV MICHIGAN STATE ,  ZEIKUS J GREGORY ,  MCKINLAY JAMES B ,  LAIVENIEKS MARIS ,  VIEILLE CLAIRE

    Inventor： ZEIKUS J GREGORY ,  MCKINLAY JAMES B ,  LAIVENIEKS MARIS ,  VIEILLE CLAIRE

    IPC: C12N1/20 ,  A61K39/02

    CPC classification number: C12P7/46 ,  C07K14/285 ,  C12P7/50 ,  C12P13/001 ,  C12P13/14 ,  C12P13/20

    Abstract: Actinobacillus succinogenes genes and methods of using the genes in genetically engineered A. succinogenes so as to improve production of chemicals such as succinate, fumarate, malate, 5-aminolevulinate, 2-oxoglutarate, glutamate, and aspartate. The genetically engineered A. succinogenes strains are capable of overexpressing C4 enzymes. The genetically engineered A. succinogenes can have one or more gene knockouts or modifications that inhibit C3 enzymes. The fluxes supplying substrate to the C4 pathway can also be improved in some of the genetically engineered A. succinogenes.

    Abstract translation: 放线芽胞杆菌属基因和使用基因工程改造的琥珀酸酵母中的基因的方法，以改善琥珀酸盐，富马酸盐，苹果酸盐，5-氨基乙酰丙酸盐，2-氧戊二酸盐，谷氨酸盐和天冬氨酸盐等化学品的生产。 遗传工程化的琥珀酸酵母菌株能够过量表达C4酶。 遗传工程化的琥珀酸酵母可以具有抑制C3酶的一种或多种基因敲除或修饰。 向C4途径提供底物的助熔剂也可以在一些遗传工程的A.succinogenes中得到改善。

    Ｎ−ホルミルアミノ酸の製造方法及びその使用
    9.
    发明申请
    Ｎ−ホルミルアミノ酸の製造方法及びその使用 审中-公开
    生产N-甲醛酸的方法及其利用

    公开(公告)号：WO2002085840A1

    公开(公告)日：2002-10-31

    申请号：PCT/JP2002/003754

    申请日：2002-04-16

    Applicant: 味の素株式会社 ,  河原 滋 ,  竹本 正 ,  藤田 伸二 ,  大野 綾子

    Inventor： 河原 滋 ,  竹本 正 ,  藤田 伸二 ,  大野 綾子

    IPC: C07C231/02

    CPC classification number: C07K5/0613 ,  C07C231/02 ,  C07C231/08 ,  C12P13/02 ,  C12P13/20 ,  C12P21/02 ,  C07C233/47

    Abstract: A process for efficiently and industrially advantageously producing an N-formylamino acid by reacting an amino acid or its salt with formamide and/or methyl formate in the presence of a base. A process for efficiently and industrially advantageously producing N-formyl- alpha -aspartylphenylalanine methyl ester, which is a precursor of aspartame, by an enzymatic fusion reaction of N-formylaspartic acid with phenylalanine methyl ester wherein the concentration of N-formylaspartic acid is specified or the reaction is carried out in the presence of a trialkyl phosphate. A process for efficiently and industrially advantageously producing N-formyl- alpha -aspartylphenylalanine methyl ester having a high purity by adjusting the pH value of a phenylalanine methyl ester adduct of N-formyl- alpha -aspartylphenylalanine methyl ester.

    Abstract translation: 一种通过在碱存在下使氨基酸或其盐与甲酰胺和/或甲酸甲酯反应而有效和工业上有利地生产N-甲酰氨基酸的方法。 通过N-甲酰天冬氨酸与苯丙氨酸甲酯的酶融合反应有效地产生N-甲酰基-α-天冬氨酰苯丙氨酸甲酯（其是天冬甜素的前体）的方法，其中指定N-甲酰天冬氨酸的浓度或 反应在磷酸三烷基酯存在下进行。 通过调节N-甲酰基-α-天冬酰苯基苯丙氨酸甲酯的苯丙氨酸甲酯加合物的pH值，有效地和工业上有利地生产具有高纯度的N-甲酰基-asp-酰基苯丙氨酸甲酯的方法。

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