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公开(公告)号：WO2011061629A3
公开(公告)日：2011-12-01
申请号：PCT/IB2010003154
申请日：2010-11-19
Applicant: OXYRANE UK LTD , GEYSENS STEVEN CHRISTIAN JOZEF , VERVECKEN WOUTER
Inventor： GEYSENS STEVEN CHRISTIAN JOZEF , VERVECKEN WOUTER
CPC classification number: C12N9/1051 , C07K16/32 , C07K2317/14 , C07K2317/41 , C12N9/2402 , C12N9/2488 , C12N9/60 , C12N15/81 , C12P21/005 , C12Y204/01 , C12Y204/01133 , C12Y302/01024 , C12Y302/01084 , C12Y302/01114
Abstract: Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosylation pathway.
Abstract translation: 本文描述了用于在哺乳动物糖基化途径中产生包含哺乳动物样复合体N-聚糖或含有中间体的靶分子的方法和基因工程真菌细胞。
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2.发明申请FUSION CONSTRUCTS AND USE OF SAME TO PRODUCE ANTIBODIES WITH INCREASED FC RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION 审中-公开融合结构及其用途生产具有增强的FC受体结合亲和力和效应功能的抗体
公开(公告)号：WO2004065540A3
公开(公告)日：2005-03-24
申请号：PCT/IB2004000844
申请日：2004-01-22
Applicant: GLYCART BIOTECHNOLOGY AG , UMANA PABLO , BRUENKER PETER , FERRARA CLAUDIA , SUTER TOBIAS
Inventor： UMANA PABLO , BRUENKER PETER , FERRARA CLAUDIA , SUTER TOBIAS
IPC: A61K38/00 , C07K16/28 , C07K16/30 , C07K16/32 , C12N9/10 , C12N9/24 , C12N15/62 , C12P21/00 , C07K16/00 , C12N15/54
CPC classification number: C07K16/2887 , A61K38/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/05 , C12N9/1051 , C12N9/2488 , C12N15/62 , C12P21/005 , C12Y204/01038 , C12Y204/01144 , C12Y302/01024 , C12Y302/01096 , C12Y302/01114
Abstract: The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Abstract translation: 本发明涉及蛋白质的糖基化工程领域。 更具体地说，本发明涉及具有催化活性的核酸分子，包括具有催化活性的核糖分子，以及其在宿主细胞的糖基化工程中的用途，以产生具有改善的治疗性质的多肽，包括具有增加的Fc受体结合和增加的效应子功能的抗体。
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3.发明申请METHOD OF GENERATING HYPOALLERGENIC GLYCOPROTEINS IN MUTATED OR TRANSGENIC PLANTS OR PLANT CELLS, AND MUTATED OR TRANSGENIC PLANTS AND PLANT CELLS FOR GENERATING HYPOALLERGENIC GLYCOPROTEINS 审中-公开方法来生成低过敏性糖蛋白突变体的或转基因植物或植物细胞和突变或转基因植物和植物细胞于产生低过敏性糖蛋白
公开(公告)号：WO2009135603A8
公开(公告)日：2011-02-24
申请号：PCT/EP2009003033
申请日：2009-04-25
Applicant: UNIV MUENSTER WILHELMS , VON SCHAEWEN ANTJE , KAULFUERST-SOBOLL HEIDI
Inventor： VON SCHAEWEN ANTJE , KAULFUERST-SOBOLL HEIDI
CPC classification number: C12P21/005 , C12N9/1051 , C12N9/2402 , C12N15/8257 , C12N15/8258 , C12Y204/01065 , C12Y302/01045 , C12Y302/01114
Abstract: The present invention relates to a method of generating hypoallergenic glycoproteins in mutated or transgenic plants, parts of these plants, or plant cells produced therefrom, and also to the corresponding mutated or transgenic plants, plant parts and plant cells, in which the activity of the enzyme Golgi a-mannosidase II is eliminated or reduced, and which produce hypoallergenic heterologous glycoproteins.
Abstract translation: 本发明涉及一种用于生产由其以及与相应的突变或转基因植物，植物部分和植物细胞，其中所述酶的活性高尔基体甘露糖苷酶消除或减少II产生的突变体低变应原性的糖蛋白，或转基因植物，这些植物的部分或植物细胞 和产生低变应原性异源糖蛋白。
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4.发明申请FUSION CONSTRUCTS AND USE OF SAME TO PRODUCE ANTIBODIES WITH INCREASED FC RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION 审中-公开融合结构及其用途生产具有增强的FC受体结合亲和力和效应功能的抗体
公开(公告)号：WO2004065540A2
公开(公告)日：2004-08-05
申请号：PCT/IB2004/000844
申请日：2004-01-22
Applicant: GLYCART BIOTECHNOLOGY AG , UMANA, Pablo , BRUENKER, Peter , FERRARA, Claudia , SUTER, Tobias
Inventor： UMANA, Pablo , BRUENKER, Peter , FERRARA, Claudia , SUTER, Tobias
IPC: C12N
CPC classification number: C07K16/2887 , A61K38/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/05 , C12N9/1051 , C12N9/2488 , C12N15/62 , C12P21/005 , C12Y204/01038 , C12Y204/01144 , C12Y302/01024 , C12Y302/01096 , C12Y302/01114
Abstract: The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Abstract translation: 本发明涉及蛋白质的糖基化工程领域。 更具体地说，本发明涉及具有催化活性的核酸分子，包括具有催化活性的核糖分子，以及其在宿主细胞的糖基化工程中的用途，以产生具有改善的治疗性质的多肽，包括具有增加的Fc受体结合和增加的效应子功能的抗体。
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5.发明申请VERFAHREN ZUR ERZEUGUNG VON HYPOALLERGENEN GLYKOPROTEINEN IN MUTIERTEN ODER TRANSGENEN PFLANZEN ODER PFLANZENZELLEN SOWIE MUTIERTE ODER TRANSGENE PFLANZEN UND PFLANZENZELLEN ZUR ERZEUGUNG HYPOALLERGENER GLYKOPROTEINE 审中-公开方法来生成低过敏性糖蛋白突变体的或转基因植物或植物细胞和突变或转基因植物和植物细胞于产生低过敏性糖蛋白
公开(公告)号：WO2009135603A1
公开(公告)日：2009-11-12
申请号：PCT/EP2009/003033
申请日：2009-04-25
Applicant: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER , VON SCHAEWEN, Antje , KAULFÜRST-SOBOLL, Heidi
Inventor： VON SCHAEWEN, Antje , KAULFÜRST-SOBOLL, Heidi
CPC classification number: C12P21/005 , C12N9/1051 , C12N9/2402 , C12N15/8257 , C12N15/8258 , C12Y204/01065 , C12Y302/01045 , C12Y302/01114
Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Erzeugung von hypoallergenen Glykoproteinen in mutierten oder transgenen Pflanzen, Teilen dieser Pflanzen oder daraus hergestellten Pflanzenzellen sowie die entsprechenden mutierten oder transgenen Pflanzen, Pflanzenteile und Pflanzenzellen, bei welchen die Aktivität des Enzyms Golgi α-Mannosidase II beseitigt oder verringert ist und welche hypoallergene heterologe Glykoproteine produzieren.
Abstract translation: 本发明涉及一种用于生产由其以及与相应的突变或转基因植物，植物部分和植物细胞，其中所述酶的活性高尔基体甘露糖苷酶消除或减少II产生的突变体低变应原性的糖蛋白，或转基因植物，这些植物的部分或植物细胞 和产生低变应原性异源糖蛋白。
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Patent Agency Ranking6.发明申请EXPRESSION OF CLASS 2 MANNOSIDASE AND CLASS III MANNOSIDASE IN LOWER EUKARYOTIC CELLS 审中-公开在较低的原核细胞中表达2类曼卡塞菌素和第3类芒果苷
公开(公告)号：WO2004074498A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/005132
申请日：2004-02-20
Applicant: HAMILTON, Stephen, R. , GERNGROSS, Tillman, U. , WILDT, Stefan , CHOI, Byung-Kwon , NETT, Juergen, Hermann , BOBROWICZ, Piotr , DAVIDSON, Robert, C.
Inventor： HAMILTON, Stephen, R. , GERNGROSS, Tillman, U. , WILDT, Stefan , CHOI, Byung-Kwon , NETT, Juergen, Hermann , BOBROWICZ, Piotr , DAVIDSON, Robert, C.
IPC: C12P21/00
CPC classification number: C12P21/005 , A01K2217/075 , C12N9/1051 , C12N9/2488 , C12N15/79 , C12Y302/01024 , C12Y302/01114
Abstract: A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manαl,3 and Manαl,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway.
Abstract translation: 公开了通过在低等真核生物中表达具有Manalphal，3和Manalphal，6个糖苷键的底物特异性的2类α-甘露糖苷酶来生产人样糖蛋白的方法。 在寡糖上的这些键合的水解产生用于在分泌途径中进一步N-聚糖加工的底物。
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公开(公告)号：WO2004003194A3
公开(公告)日：2004-04-22
申请号：PCT/EP0306711
申请日：2003-06-25
Applicant: FLANDERS INTERUNIVERSITY INST
Inventor： CONTRERAS ROLAND , CALLEWAERT NICO L M , GEYSENS STEVEN C J , KAIGORODOV VLADIMIR , WOUTER VERVECKEN
CPC classification number: C12Y302/01114 , C12N9/1288 , C12N9/2488 , C12N15/815 , C12Y302/01024
Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for alpha-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the contemplated vectors are also included in this invention.
Abstract translation: 本发明提供了甲基营养酵母的基因工程菌株，包括毕赤酵母，特别是能够产生具有降低或修饰的糖基化的蛋白质的巴斯德毕赤酵母。 还提供了使用这种基因工程化的毕赤酵母菌株生产具有降低的和/或修饰的糖基化的糖蛋白的方法。 包含用于转化甲基营养酵母的α-1,2-甘露糖苷酶I，葡糖苷酶II，GlcNAc-转移酶I和甘露糖苷酶II或包含OCH1破坏序列的编码序列的载体被本发明考虑。 用于提供预期载体的试剂盒也包括在本发明中。
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8.发明申请
公开(公告)号：WO2011061629A2
公开(公告)日：2011-05-26
申请号：PCT/IB2010/003154
申请日：2010-11-19
Applicant: OXYRANE UK LIMITED , GEYSENS, Steven Christian, Jozef , VERVECKEN, Wouter
Inventor： GEYSENS, Steven Christian, Jozef , VERVECKEN, Wouter
IPC: C12N1/00
CPC classification number: C12N9/1051 , C07K16/32 , C07K2317/14 , C07K2317/41 , C12N9/2402 , C12N9/2488 , C12N9/60 , C12N15/81 , C12P21/005 , C12Y204/01 , C12Y204/01133 , C12Y302/01024 , C12Y302/01084 , C12Y302/01114
Abstract: Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosylation pathway.
Abstract translation: 本文描述了可用于产生含有哺乳动物样复合N-聚糖的靶分子或在哺乳动物糖基化途径中含有中间体的遗传工程真菌细胞。
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公开(公告)号：WO2006026992A1
公开(公告)日：2006-03-16
申请号：PCT/DK2005/000569
申请日：2005-09-07
Applicant: NOVOZYMES A/S , JØRGENSEN, Christel, Thea , HJORT, Carsten
Inventor： JØRGENSEN, Christel, Thea , HJORT, Carsten
CPC classification number: C12N9/2488 , C07K2319/04 , C07K2319/05 , C12N1/14 , C12N15/80 , C12Y204/01038 , C12Y204/01101 , C12Y204/01143 , C12Y302/01113 , C12Y302/01114
Abstract: The present invention relates to methods for altering the structure of N-glycans in fun-gal cells and to fungal cells having an altered N-glycan structure.
Abstract translation: 本发明涉及用于改变游离gal细胞中N-聚糖结构的方法和具有改变的N-聚糖结构的真菌细胞。
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10.发明申请EXPRESSION OF CLASS 2 MANNOSIDASE AND CLASS III MANNOSIDASE IN LOWER EUKARYOTIC CELLS 审中-公开在较低的原核细胞中表达2类曼卡塞菌素和第3类芒果苷
公开(公告)号：WO2004074498A3
公开(公告)日：2005-06-23
申请号：PCT/US2004005132
申请日：2004-02-20
Applicant: HAMILTON STEPHEN R , GERNGROSS TILLMAN U , WILDT STEFAN , CHOI BYUNG-KWON , NETT JUERGEN HERMANN , BOBROWICZ PIOTR , DAVIDSON ROBERT C
Inventor： HAMILTON STEPHEN R , GERNGROSS TILLMAN U , WILDT STEFAN , CHOI BYUNG-KWON , NETT JUERGEN HERMANN , BOBROWICZ PIOTR , DAVIDSON ROBERT C
CPC classification number: C12P21/005 , A01K2217/075 , C12N9/1051 , C12N9/2488 , C12N15/79 , C12Y302/01024 , C12Y302/01114
Abstract: A method for producing human-like glycoproteins by expressing a Class 2 alpha-mannosidase having a substrate specificity for Manalphal,3 and Manalphal,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway.
Abstract translation: 公开了通过在低等真核生物中表达具有Manalphal，3和Manalphal，6个糖苷键的底物特异性的2类α-甘露糖苷酶来生产人样糖蛋白的方法。 在寡糖上的这些键合的水解产生用于在分泌途径中进一步N-聚糖加工的底物。
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