APPARATUS AND METHODS FOR REDUCED NEUTRAL CONTAMINATION IN A MASS SPECTROMETER

    公开(公告)号:WO2019012367A1

    公开(公告)日:2019-01-17

    申请号:PCT/IB2018/054874

    申请日:2018-06-29

    CPC classification number: H01J49/067

    Abstract: Apparatus and methods for controlling contamination of components contained within the high- vacuum chambers of mass spectrometer systems are provided. The apparatus and methods employ a beam of neutral gas injected in a contra-flow configuration to incoming particle stream from the ionization chamber. The contra-flow can be in the directly opposite counter-flow direction (e.g., 180 degrees) or at a cross-flow angle to the incoming ion stream (e.g., flowing at an angle between about 10 degrees and 170 degrees). The contra-flow disrupts the axial gas flow and diverts neutral molecules and other undesirable contaminants before they reach the high vacuum stages (e.g., beyond the IQ0 orifice) of the spectrometer. By reducing the transmission of contaminants into the sensitive components housed deep within the mass spectrometer, the present invention can increase throughput, improve robustness, and/or decrease the downtime typically required to vent/disassemble/clean the fouled components.

    THIN FIELD TERMINATOR FOR LINEAR QUARUPOLE ION GUIDES, AND RELATED SYSTEMS AND METHODS
    2.
    发明申请
    THIN FIELD TERMINATOR FOR LINEAR QUARUPOLE ION GUIDES, AND RELATED SYSTEMS AND METHODS 审中-公开
    用于线性QUARUPOLE ION指南的薄场终端器及相关系统和方法

    公开(公告)号:WO2016127079A1

    公开(公告)日:2016-08-11

    申请号:PCT/US2016/016815

    申请日:2016-02-05

    CPC classification number: H01J49/063 H01J3/18 H01J49/067 H01J49/26 H01J49/4215

    Abstract: A field terminator includes a plurality of electrode plates positioned around a guide axis at a radial distance therefrom. The plates generate a quadrupole DC field such that a polarity on each plate is opposite to a polarity on the plates adjacent thereto. The plates may be positioned at an axial end of a quadrupole ion guide such as a mass filter. In addition to an RF field, the ion guide may generate a quadrupole DC field. The DC field of the plates may be opposite in polarity to that of the ion guide.

    Abstract translation: 场终止器包括多个电极板,定位在引导轴线的径向距离处。 板产生四极DC场,使得每个板上的极性与相邻的板上的极性相反。 板可以位于四极离子导向器的轴向端部,例如质量过滤器。 除了RF场之外,离子导向器可以产生四极DC场。 板的DC场可能与离子导向器的极性相反。

    IMPROVEMENTS IN AND RELATING TO MASS SPECTROMETRY
    3.
    发明申请
    IMPROVEMENTS IN AND RELATING TO MASS SPECTROMETRY 审中-公开
    改进和相关质谱

    公开(公告)号:WO2015181564A1

    公开(公告)日:2015-12-03

    申请号:PCT/GB2015/051569

    申请日:2015-05-29

    CPC classification number: H01J49/067 H01J49/24

    Abstract: An ion transfer apparatus for transferring ions from an ion source at a first pressure, which first pressure is >500 mbar, suitably atmospheric pressure, along a path towards a mass spectrometer at a lower second pressure, comprising a plurality of pressure- control chambers each comprising an ion inlet opening for receiving therein ions from said ion source on said path and an ion outlet opening for outputting said ions on said path; wherein said plurality of pressure-control chambers are arranged in succession along said path whereby a said ion outlet opening of each pressure-control chamber is in flow communication with a said ion inlet opening of a successive adjacent pressure- control chamber; a pump apparatus in flow communication with each said pressure- control chamber via a respective plurality of pressure exhaust openings formed within each said pressure-control chamber, and arranged to control the pressure in each respective pressure-control chamber to be lower than the pressure in a preceding adjacent pressure-control chamber such that the pressure in a last of said pressure- control chambers is the lowest amongst the plurality of pressure-control chambers.

    Abstract translation: 一种离子转移装置,用于在第一压力(第一压力> 500mbar)适当地大气压下将离子从离子源转移到沿质子分析仪的较低的第二压力的路径,每个压力控制室包括多个压力控制室 包括用于从所述路径上的所述离子源接收离子的离子入口和用于在所述路径上输出所述离子的离子出口; 其特征在于,所述多个压力控制室沿着所述路径连续布置,由此每个压力控制室的所述离子出口与所述相邻的压力控制室的所述离子入口开口流动连通; 一个与每个所述压力控制室经由形成在每个所述压力控制室内的相应多个压力排气开口流动连通的泵装置,并被布置成将每个压力控制室中的压力控制在低于 前一相邻的压力控制室,使得最后的压力控制室中的压力在多个压力控制室中是最低的。

    REFLECTRONS AND METHODS OF PRODUCING AND USING THEM
    4.
    发明申请
    REFLECTRONS AND METHODS OF PRODUCING AND USING THEM 审中-公开
    电子生产与使用方法

    公开(公告)号:WO2014194023A2

    公开(公告)日:2014-12-04

    申请号:PCT/US2014/039900

    申请日:2014-05-29

    CPC classification number: H01J49/067 H01J49/405

    Abstract: Certain embodiments described herein are directed to reflectron assemblies and methods of producing them. In some configurations, a reflectron comprising a plurality of lenses each comprising a planar body and comprising a plurality of separate and individual conductors spanning a central aperture from a first side to a second side of a first surface of the planar body is described. In some instances, the plurality of conductors are each substantially parallel to each other and are positioned in the same plane.

    Abstract translation: 本文描述的某些实施例涉及反射器组件及其制造方法。 在一些配置中,描述了包括多个透镜的反射器,每个透镜都包括平面主体,并且包括跨越从平面主体的第一表面的第一侧到第二侧的中心孔的多个单独和独立的导体。 在一些情况下,多个导体各自基本上彼此平行并且位于同一平面中。

    AN IMPROVED INTERFACE FOR MASS SPECTROMETRY APPARATUS
    5.
    发明申请
    AN IMPROVED INTERFACE FOR MASS SPECTROMETRY APPARATUS 审中-公开
    改进的大规模光谱仪器接口

    公开(公告)号:WO2013134833A1

    公开(公告)日:2013-09-19

    申请号:PCT/AU2013/000271

    申请日:2013-03-18

    CPC classification number: H01J49/067 H01J49/009 H01J49/105 H01J49/26

    Abstract: There is provided an interface for use in sampling ions in a mass spectrometer, the interface being arranged for receiving a quantity of ions from an ion source and forming more than one ion beam therefrom, each ion beam being directed along a respective desired pathway.

    Abstract translation: 提供了一种用于在质谱仪中对离子进行采样的界面,该界面布置成从离子源接收一定数量的离子并从其形成多于一个的离子束,每个离子束沿相应的期望路径被引导。

    ION REGULATOR FOR MASS SPECTROMETER, MASS SPECTROMETER COMPRISING THE SAME AND METHOD OF REGULATING ION FOR MASS SPECTROMETER
    6.
    发明申请
    ION REGULATOR FOR MASS SPECTROMETER, MASS SPECTROMETER COMPRISING THE SAME AND METHOD OF REGULATING ION FOR MASS SPECTROMETER 审中-公开
    用于质谱仪的离子稳压器,包含其的质谱仪和用于质谱仪的调节方法

    公开(公告)号:WO2013055081A1

    公开(公告)日:2013-04-18

    申请号:PCT/KR2012/008178

    申请日:2012-10-10

    CPC classification number: H01J49/067 H01J49/40

    Abstract: An ion regulator for a mass spectrometer may include: a first extraction lens having a first hole through which ions can pass; and a second extraction lens electrically isolated from the first extraction lens and having a second hole which is aligned with the first hole so that the ions passing through the first hole can pass therethrough. The surface of the first hole may be inclined with respect to the moving direction of the ions. Use of the ion regulator will simplify the overall structure of a mass spectrometer and control parameters therefor, and will allow the development of a reliable and efficient compact mass spectrometer.

    Abstract translation: 用于质谱仪的离子调节器可以包括:具有离子可以通过的第一孔的第一提取透镜; 以及与所述第一提取透镜电隔离并且具有与所述第一孔对准的第二孔的第二提取透镜,使得穿过所述第一孔的所述离子可以通过。 第一孔的表面可以相对于离子的移动方向倾斜。 离子调节器的使用将简化质谱仪的总体结构并控制其参数,并且将允许开发可靠且高效的紧凑型质谱仪。

    MASS SPECTROMETRY FOR GAS ANALYSIS IN WHICH BOTH A CHARGED PARTICLE SOURCE AND A CHARGED PARTICLE ANALYZER ARE OFFSET FROM AN AXIS OF A DEFLECTOR LENS, RESULTING IN REDUCED BASELINE SIGNAL OFFSETS
    7.
    发明申请
    MASS SPECTROMETRY FOR GAS ANALYSIS IN WHICH BOTH A CHARGED PARTICLE SOURCE AND A CHARGED PARTICLE ANALYZER ARE OFFSET FROM AN AXIS OF A DEFLECTOR LENS, RESULTING IN REDUCED BASELINE SIGNAL OFFSETS 审中-公开
    用于气体分析的大量光谱分析,其中充电颗粒源和充电颗粒分析仪偏离偏光镜的轴,从而降低基线信号偏差

    公开(公告)号:WO2012170170A1

    公开(公告)日:2012-12-13

    申请号:PCT/US2012/038275

    申请日:2012-05-17

    CPC classification number: H01J49/067 H01J49/061

    Abstract: Apparatus, methods and systems are provided to inhibit a sightline from a charged particle source to an analyzer and for changing a baseline offset of an output spectrum of an analyzer. A supply of charged particles is directed through a hollow body of a deflector lens that is positioned relative to a charged particle source and an analyzer. A flow path along a preferred flow path through a deflector lens permits passage of the ions from the source to the detector while inhibiting a sightline from the detector to the source in a direction parallel to the central longitudinal axis of the deflector lens.

    Abstract translation: 提供了装置,方法和系统以阻止从带电粒子源到分析器的视线以及用于改变分析仪的输出光谱的基线偏移。 带电粒子的供应被引导通过相对于带电粒子源和分析器定位的偏转器透镜的空心体。 沿通过偏转器透镜的优选流动路径的流动路径允许离子从源到检测器的通过,同时在平行于偏转器透镜的中心纵向轴线的方向上将检测器从检测器到源的阻挡。

    MASS SPECTROMETRY FOR GAS ANALYSIS WITH A ONE-STAGE CHARGED PARTICLE DEFLECTOR LENS BETWEEN A CHARGED PARTICLE SOURCE AND A CHARGED PARTICLE ANALYZER BOTH OFFSET FROM A CENTRAL AXIS OF THE DEFLECTOR LENS
    8.
    发明申请
    MASS SPECTROMETRY FOR GAS ANALYSIS WITH A ONE-STAGE CHARGED PARTICLE DEFLECTOR LENS BETWEEN A CHARGED PARTICLE SOURCE AND A CHARGED PARTICLE ANALYZER BOTH OFFSET FROM A CENTRAL AXIS OF THE DEFLECTOR LENS 审中-公开
    气体分析用气体分析与充电颗粒源和充电颗粒分析仪之间的一级充电颗粒偏光镜透镜从偏光镜的中心轴偏移

    公开(公告)号:WO2012170168A2

    公开(公告)日:2012-12-13

    申请号:PCT/US2012038271

    申请日:2012-05-17

    CPC classification number: H01J49/061 H01J49/062 H01J49/067

    Abstract: Apparatus, methods and systems are provided to inhibit a sightline from a charged particle source to an analyzer and for changing a baseline offset of an output spectrum of an analyzer. A supply of charged particles is directed through a hollow body of a deflector lens that is positioned relative to a charged particle source and an analyzer. A flow path along a preferred flow path through a deflector lens permits passage of the ions from the source to the detector while inhibiting a sightline from the detector to the source in a direction parallel to the central longitudinal axis of the deflector lens.

    Abstract translation: 提供了装置,方法和系统以阻止从带电粒子源到分析器的视线以及用于改变分析仪的输出光谱的基线偏移。 带电粒子的供应被引导通过相对于带电粒子源和分析器定位的偏转器透镜的空心体。 沿通过偏转器透镜的优选流动路径的流动路径允许离子从源到检测器的通过,同时在平行于偏转器透镜的中心纵向轴线的方向上将检测器从检测器到源的阻挡。

    質量分析装置
    9.
    发明申请
    質量分析装置 审中-公开
    质谱仪

    公开(公告)号:WO2012165053A1

    公开(公告)日:2012-12-06

    申请号:PCT/JP2012/059681

    申请日:2012-04-09

    Inventor: 三瓶 誠人

    Abstract: 試料イオン化装置(イオン源)からの試料導入の際、イオン化が不充分であった試料が導入部細孔以外の部位に滞留し、熱などのエネルギーにより、酸化物ないし炭化物などの生成物として堆積する。その堆積する生成物は質量分析装置の性能劣化の原因となる。本発明は、試料供給源と、試料供給源から供給される試料をイオン化する試料イオン化部と、イオン化された試料イオンが導入される試料導入抑制室と、試料導入抑制室の下流になる差動排気室と、差動排気室の下流側になる分析部を有する質量分析装置において、試料導入抑制室、前記差動排気室の少なくとも一方の内部で放電を生成する放電生成手段を有する。そして、放電生成手段は、試料導入抑制室で対向するように設けた対向する試料導入部電極と第一細孔部用部材(電極)、ないし前記差動排気室で対向するように設けた第一細孔部用部材(電極)と第二細孔部用部材(電極)を有することを特徴とする。

    Abstract translation: 在从样品电离装置(离子源)注入样品期间,不充分电离的样品可能沉积在注射部分的小孔以外的区域中,并且由于能量而以诸如氧化物或碳化物的形式积聚在那里 如热。 积聚的产物可能会降低质谱装置的性能。 本发明提供一种质谱装置,其具有:试样供给源; 用于使由所述检体供给源供给的试样离子化的检体离子化部; 注入离子化试样离子的试样注入调节室; 位于试样注射调节室下游的差动排空室; 以及位于所述差动排空室下游的分析部分; 其中所述装置具有用于在所述检体注入调节室和/或所述差动排空室的内部产生放电的放电产生装置。 放电产生装置的特征在于具有相对的样本注入部分电极和在样本注入调节室中彼此面对地设置的第一小孔部分限定部件(电极); 以及第一小孔部分限定部件(电极)和第二小孔部分限定部件(电极),所述第二小孔部分限定部件(电极)被布置为在差动排空室中彼此面对。

    飛行時間型質量分析装置
    10.
    发明申请
    飛行時間型質量分析装置 审中-公开
    飞行时间质谱仪

    公开(公告)号:WO2012132550A1

    公开(公告)日:2012-10-04

    申请号:PCT/JP2012/052593

    申请日:2012-02-06

    CPC classification number: H01J49/067 H01J49/401

    Abstract:  直交加速部にイオンを送り込むイオン入射光学系として、5個の円筒状電極(31~35)がイオン光軸(C)に沿って配置され、アフォーカル条件の下で形成される2つの仮想凸レンズ(L1、L2)の共通焦点面上にアパーチャ板(38)が配置された静電レンズ(3)を用いる。アパーチャ板(38)に形成された絞り開口(39)の径によって出射イオンビームの角度広がりが決まる。静電レンズ(3)がアフォーカル系となるように印加電圧が設定されると、感度は若干犠牲になるものの高質量分解能の測定が可能となり、イオン通過率が最大である非アフォーカル系となるように印加電圧が設定されると、分解能は若干犠牲になるものの高感度の測定が可能となる。これにより、直交加速方式TOFMSにおいて質量分解能優先モードと測定感度優先モードとを簡単に切替えられる。

    Abstract translation: 一种静电透镜(3),其中,作为用于将离子发送到正交加速单元的离子入射光学系统,沿离子光轴(C)和孔板(38)布置五个圆柱形电极(31-35) )设置在形成在无焦条件下的两个虚拟凸透镜(L1,L2)的公共焦平面上。 形成在孔板(38)中的孔口(39)的直径决定了出射离子束的角度扩展。 当设置施加电压使得静电透镜(3)成为无焦点系统时,可以通过稍微牺牲灵敏度来执行具有高质量分辨率的测量,并且当施加电压使得静电透镜(3) 成为离子通过率最大的非焦点系统,可以通过稍微牺牲分辨率来进行高灵敏度的测量。 因此,在正交加速型TOFMS中,可以容易地切换质量分辨率优先模式和测量灵敏度优先模式。

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