TRANSDERMAL PSYCHOACTIVE ALKALOID COMPOSITION AND PREPARATION THEREOF

    公开(公告)号:WO2022140842A1

    公开(公告)日:2022-07-07

    申请号:PCT/CA2021/051702

    申请日:2021-11-29

    摘要: A transdermal psychoactive alkaloid composition including a psychoactive alkaloid extract or synthetic psychoactive alkaloid. The alkaloids in the extract are predominantly dephosphorylated rather than phosphorylated. The transdermal psychoactive alkaloid composition also includes an alcohol carrier, a permeation enhancer, a thickener or gelling agent, and optional further excipients. A process for obtaining a transdermal psychoactive alkaloid composition includes dephosphorylating the alkaloid during extraction, purifying the extracted alkaloid, and standardizing it to a specific concentration by adding measured quantities of excipients.

    一种猴头菇膳食纤维、制备方法及其应用

    公开(公告)号:WO2022134293A1

    公开(公告)日:2022-06-30

    申请号:PCT/CN2021/076781

    申请日:2021-02-19

    摘要: 本发明公开了一种猴头菇膳食纤维、制备方法及其应用,属于食品加工技术领域,所述制备方法包括以下步骤:将提取多糖和蛋白后的猴头菇残渣水洗,粉碎,干燥,备用;按照1g:(30~40)mL的料液比加入蒸馏水,加入碱性蛋白酶酶解25~30min;调节pH至5~6,加入纤维素酶进行酶解,酶解的同时进行微波-超声处理,沸水浴灭酶10~15min;加入乙醇溶液,经抽滤、洗涤、干燥得到猴头菇膳食纤维。所述猴头菇膳食纤维呈簇状结构,表面结构被破坏,可以束缚、破坏脂肪乳状液,提高粪便中胆汁酸排泄能力,改善胆汁酸的代谢,在小肠内延迟对脂类和胆固醇的扩散和吸收。

    EXTRACTION OF PSYCHOACTIVE COMPOUNDS FROM PSYCHEDELIC FUNGUS

    公开(公告)号:WO2021253123A1

    公开(公告)日:2021-12-23

    申请号:PCT/CA2021/050822

    申请日:2021-06-16

    摘要: This invention relates to the extraction of psychoactive compounds from psychedelic fungus for use in medicine. Raw psychedelic fungus is dried and ground. The solvent used for extraction is a lower aliphatic alcohol, water, a hydro-alcohol mixture, an acidic hydro-alcohol mixture, or an alkaline hydro-alcohol mixture. The extraction slurry is filtered and pH-adjusted if necessary. The solvent is then partially evaporated, or completely evaporated with water added back, to form a concentrated slurry. The concentrated slurry is then standardized to provide a known concentration of the psychoactive alkaloids that have been extracted. The standardized slurry may then be dried to result in a powdered psilocybin mushroom extract with a precisely defined purity.