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    METHODS AND COMPOSITIONS OF INCORPORATING A BIOACTIVE AGENT AND USE THEREOF
    4.
    发明申请
    METHODS AND COMPOSITIONS OF INCORPORATING A BIOACTIVE AGENT AND USE THEREOF 审中-公开

    公开(公告)号：WO2018217588A1

    公开(公告)日：2018-11-29

    申请号：PCT/US2018/033560

    申请日：2018-05-20

    申请人： INNOVANUTRA INC.

    发明人： RANGANATHAN, Anupama, Tarakkad ,  PARKS, Mario, Christopher ,  YOUNG, Stephen, Allan

    IPC分类号： A61K36/00 ,  A61K36/27 ,  A61K36/45

    摘要： Provided herein are compositions comprising a carrier and one or more bioactive agents in which one or more bioactive agents are incorporated into said carrier. Sugars that are naturally present with one or more bioactive agents as mixture are preferentially excluded out of said carrier in the composition. The compositions have wide applications including, but not limited to food and beverage industries. Also provided are methods of incorporating one or more bioactive agents into a carrier, compositions comprising a carrier and one or more bioactive agents and use of such methods and compositions, and kits. The methods are useful for (a) improving color, thermal, photo, and oxidative stability of bioactive agents, e.g., natural food colorants and other bioactive ingredients, (b) reducing and eliminating the usage of artificial chemicals such as sacrificial antioxidants and metal ion chelators that are used to improve bioactive stability.

    PROCESS FOR PREPARING AN EDIBLE COMPOSITION COMPRISING STEROIDAL GLYCOSIDES
    8.
    发明申请
    PROCESS FOR PREPARING AN EDIBLE COMPOSITION COMPRISING STEROIDAL GLYCOSIDES 审中-公开
    制备包含非甾体类糖苷的食用组合物的方法

    公开(公告)号：WO2007096217A1

    公开(公告)日：2007-08-30

    申请号：PCT/EP2007/050482

    申请日：2007-01-18

    申请人： UNILEVER N.V. ,  UNILEVER PLC ,  HINDUSTAN LEVER LIMITED ,  ABRAHAMSE, Salomon, Leendert ,  VAN AMERONGEN, Ivo, Antonius ,  POVEY, Kevin, John

    发明人： ABRAHAMSE, Salomon, Leendert ,  VAN AMERONGEN, Ivo, Antonius ,  POVEY, Kevin, John

    IPC分类号： A23L1/30 ,  A61K36/27

    CPC分类号： C07J17/005 ,  A23L33/105 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/704 ,  A61K36/27 ,  C07J7/002 ,  A23V2250/21

    摘要： There is provided a process for preparing an edible aqueous dispersion of one or more steroidal glycosides, comprising the steps of: (a) preparing a composition comprising at least 1% by weight steroidal glycosides from plants, (b) dissolving an emulsifier having a HLB (hydrophilic lipophilic balance) value between 7 and 30 in a solvent, and (c) thoroughly homogenising the composition comprising the steroidal glycosides for about 1 to 10 minutes in the solution of the solvent and the emulsifier at a temperature of 20 to 200°C to obtain a dispersion, and d) optionally, cooling the solution to a temperature below 40°C, whereby said steroidal glycosides are dispersed to a mean particle size (D3,2) of less than 15 micrometer, wherein the ratio (w/w) of the steroidal glycosides to the emulsifier in said edible dispersion is less than 10:1.

    摘要翻译： 提供了一种制备一种或多种甾体糖苷的可食用水性分散体的方法，包括以下步骤：（a）制备包含至少1重量％的来自植物的甾体糖苷的组合物，（b）将具有HLB的乳化剂 （亲水亲油平衡）值在7至30之间，和（c）在溶剂和乳化剂的溶液中在20至200℃的温度下将包含甾体糖苷的组合物充分均化约1至10分钟 以获得分散体，以及d）任选地将溶液冷却至低于40℃的温度，由此将所述甾体糖苷分散至小于15微米的平均粒度（D3,2），其中所述比例（w / w ）所述可食用分散体中的甾体糖苷与乳化剂的比例小于10:1。

    EXTRACTS OF LATEX OF CALOTROPIS PROCERA AND TO A METHOD OF PREPARATION THEREOF
    10.
    发明申请
    EXTRACTS OF LATEX OF CALOTROPIS PROCERA AND TO A METHOD OF PREPARATION THEREOF 审中-公开
    胼CAL体法的提取及其制备方法

    公开(公告)号：WO2005099730A8

    公开(公告)日：2006-12-21

    申请号：PCT/IN2005000106

    申请日：2005-04-07

    申请人： ALL INDIA INST MED ,  ICGEB ,  KUMAR L VIJAY ,  KUMAR VIJAY

    发明人： KUMAR L VIJAY ,  KUMAR VIJAY

    IPC分类号： A61K36/27 ,  A61K35/78

    CPC分类号： A61K36/27

    摘要： The invention relates to aqueous suspension of dried latex (DL) of Calotropis procera and to a method of preparation for the prevention/treatment of cancer. The DL suspension when administered orally ín the X-myc mice - a transgenic mouse model of hepatocellular carcinoma (HCC), was effective in protecting the animals from the atypical mitosis and displastic/nenoplastic changes occuring in vivo. Further, the DL suspension did not show any observable side effects when administered orally to the animals for 16 weeks. Further, the purified fractions of the latex were found to exhibit potent cytotoxic activity in in vitro cell culture system using two different cancer cell lines.

    摘要翻译： 本发明涉及Calotropis procera的干燥胶乳（DL）的水性悬浮液以及预防/治疗癌症的方法。 口服X-myc小鼠时的DL悬浮液 - 一种肝细胞癌（HCC）的转基因小鼠模型，可有效保护动物免受非典型有丝分裂和体内发生的移位/非生物体变化。 此外，当向动物口服施用16周时，DL悬浮液没有显示任何可观察到的副作用。 此外，发现胶乳的纯化部分在使用两种不同的癌细胞系的体外细胞培养系统中表现出有效的细胞毒性活性。