公开(公告)号：WO2022240817A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028502

申请日：2022-05-10

申请人： LIKEMINDS, INC.

发明人： KOENIG, Reinhard

IPC分类号： A61K51/04 ,  A61K51/0455 ,  A61K51/0468

摘要： Disclosed are methods of dopamine transporter (DaT) visualization in the brain of a subject (e.g., a subject suspected of suffering from Parkinson's disease, dementia with Lewy bodies, or Alzheimer's disease). The methods typically include the step of intravenous administration to the subject of a first dose of [123I]altropane and the step of acquiring SPECT counts from the subject's brain (e.g., obtaining a first number of SPECT counts of the subject's brain). If the first number of SPECT counts is less than the number indicating that a final SPECT image is obtainable within one SPECT session, then the subject is uptitrated using one or more intravenous administrations of [123I]altropane in the increments of, e.g., 0.5-3 mCi of [123I]altropane, until the number of acquired SPECT counts indicates that a final SPECT image may be obtained.

公开(公告)号：WO2021118728A2

公开(公告)日：2021-06-17

申请号：PCT/US2020/059406

申请日：2020-11-06

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： EVANS, Michael ,  HUANG, Yangjie ,  DRAKE, Christopher

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K51/0455

摘要： Disclosed herein are compounds useful for detection of glucocorticoid receptor expression and activity via positron emission tomography and related techniques. Methods for preparation and use of the compounds are also described.

公开(公告)号：WO2021252775A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036830

申请日：2021-06-10

申请人： CHDI FOUNDATION, INC.

发明人： LIU, Longbin ,  LEE, Matthew ,  DOMINGUEZ, Celia ,  JOHNSON, Peter David ,  GREENAWAY, Catherine Jane ,  KHURANA, Kanika ,  MILLS, Matthew Robert ,  ROTA, Filippo

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D519/00 ,  A61K51/04 ,  A61K31/4985 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07B2200/05 ,  C07B59/002 ,  C07D231/12 ,  C07D487/14

摘要： Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, especially huntingtin protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：WO2022006007A1

公开(公告)日：2022-01-06

申请号：PCT/US2021/039436

申请日：2021-06-28

申请人： THE GENERAL HOSPITAL CORPORATION ,  AUBURN UNIVERSITY

发明人： NAHRENDORF, Matthias ,  KELIHER, Edmund J. ,  PANIZZI, Peter

IPC分类号： A61K31/4439 ,  C07D235/14 ,  C07D401/12 ,  A61K49/00 ,  A61K49/0052 ,  A61K51/0455 ,  C07B59/002

摘要： The present application provides conjugates of thrombin inhibitor dabigatran, as well as methods of using these conjugates for detecting thrombin-associated diseases or conditions, for example, for diagnosing bacterial endocarditis in the heart of the patient.

公开(公告)号：WO2021123013A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/086811

申请日：2020-12-17

申请人： JOHANNES GUTENBERG-UNIVERSITÄT MAINZ

发明人： RÖSCH, Frank ,  LAHNIF, Hanane ,  GRUS, Tilman

IPC分类号： A61K47/54 ,  A61K47/68 ,  A61K51/04 ,  A61K103/00 ,  A61P35/00 ,  A61K47/542 ,  A61K47/545 ,  A61K47/547 ,  A61K47/548 ,  A61K51/0402 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0489 ,  A61K51/0497

摘要： Ein Smart-Drug-Delivery-System für duale nuklearmedizinisch-cytotoxische Theranostik umfasst – eine erste Verbindung mit der Struktur: oder – eine zweite Verbindung mit der Struktur Chel—S—TV und eine dritte Verbindung mit der Struktur CT—L—TV; wobei in der ersten, zweiten und dritten Verbindung Chel ein Rest eines Chelators für die Komplexierung eines Radioisotops; CT ein Rest einer cytotoxischen Verbindung; TV ein biologischer Targetingvektor; L1 und L jeweils ein Linker; S1, S2 und S jeweils ein Spacer ist.

公开(公告)号：WO2023283627A1

公开(公告)日：2023-01-12

申请号：PCT/US2022/073544

申请日：2022-07-08

申请人： BLUE EARTH DIAGNOSTICS LIMITED ,  RAHMAN, Sabitur ,  BEJOT, Romain ,  LIANG, Guyan ,  HAJI, Abdul, Karim ,  BARNES, Colin

发明人： RAHMAN, Sabitur ,  BEJOT, Romain ,  LIANG, Guyan ,  HAJI, Abdul, Karim ,  BARNES, Colin

IPC分类号： A61K51/04 ,  A61K51/08 ,  A61P35/00 ,  A61K101/02 ,  A61K103/00 ,  A61K51/0446 ,  A61K51/0455 ,  A61K51/088

摘要： The present invention relates to a ligand-SIFA conjugate, comprising, within in a single molecule two separate moieties: (a) one or more ligands which are capable of binding to Fibroblast Activation Protein (FAP), and (b) a silicon-fiuoride acceptor (SI FA) moiety which comprises a covalent bond between a silicon atom and a fluorine atom.

公开(公告)号：WO2022251516A2

公开(公告)日：2022-12-01

申请号：PCT/US2022/031157

申请日：2022-05-26

申请人： CORNELL UNIVERSITY

发明人： WILSON, Justin J. ,  WOODS, Joshua J.

IPC分类号： A61K51/00 ,  C07D401/12 ,  A61K47/68 ,  A61K51/0455 ,  A61P35/00 ,  C07D213/79 ,  C07D215/26 ,  C07D215/30

摘要： The present technology provides compounds, as well as compositions including such compounds, useful in targeted radiotherapy (e.g., uranium therapy) of cancer and/or mammalian tissue overexpressing e.g., an antigen or a receptor, where the compounds are represented by the following Formulas or a pharmaceutically acceptable salt and/or solvate thereof, or a pharmaceutically acceptable salt and/or solvate thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein M1 is independently at each occurrence a radionuclide. Equivalents of such compounds are also disclosed.

公开(公告)号：WO2022072738A1

公开(公告)日：2022-04-07

申请号：PCT/US2021/053031

申请日：2021-09-30

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

发明人： SEELEY, William, W. ,  SEONG, Joon-Kyung

IPC分类号： A61K31/00 ,  A61K39/0008 ,  A61K51/0455 ,  A61P25/28

摘要： The disclosure relates to a system comprising software that predicts responsiveness of healthy subjects or subjects at risk for or suffering from Alzheimer's Disease to certain disease modifying drugs. Embodiments of the disclosure include methods comprising analyzing images of the brain for depositions of amyloid-beta (Αβ) protein and tau protein, and correlating protein deposition levels to drug responsiveness.