公开(公告)号：WO2022208369A1

公开(公告)日：2022-10-06

申请号：PCT/IB2022/052916

申请日：2022-03-30

申请人： BIOMX LTD.

发明人： ZELCBUCH, Lior, Moshe ,  EDGAR, Rotem ,  SHERMAN, Irit ,  INBAR, Dana ,  BEN-YISHAI, Noa ,  KAHAN-HANUM, Maya

IPC分类号： A61K35/76 ,  A61P31/04 ,  A61K45/06 ,  A61K9/00 ,  G01N33/00 ,  A61K31/7036 ,  A61K38/16 ,  A61K31/427 ,  A61K38/164 ,  A61K9/0031 ,  A61K9/0073

摘要： A composition comprising at least two different strains of isolated bacteriophages, each capable of infecting a bacteria of the species Pseudomonas aeruginosa, wherein at least one of said at least two different strains of isolated bacteriophages has a genomic nucleic acid sequence at least 90% identical to one of the nucleic acid sequence as set forth in SEQ ID NOs: 1-10. Uses thereof are also disclosed.

公开(公告)号：WO2022032468A8

公开(公告)日：2022-02-17

申请号：PCT/CN2020/108362

申请日：2020-08-11

申请人： 黄志祥

发明人： 黄志祥 HUANG, Chih-Hsiang

IPC分类号： A61L9/14 ,  A61K9/72 ,  A61K9/0073

摘要： 一种抗呼吸道病毒的装置及方法。抗呼吸道病毒的装置包含抗病毒液、雾化器。抗病毒液包含次氯酸。雾化器具有容置空间及出口。容置空间连通于出口并用以盛装抗病毒液。雾化器用以将抗病毒液雾化形成气雾粒子并由出口排出气雾粒子。

公开(公告)号：WO2021202928A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/025455

申请日：2021-04-01

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： WILLIAMS III, Robert, O. ,  SMYTH, Hugh, D., C. ,  WARNKEN, Zachary, N. ,  GONZALEZ, Miguel, Orlando, Jara ,  SEO, Hyo-Jong ,  BRUNAUGH, Ashee, D. ,  HERPIN, Matthew

IPC分类号： A61K31/609 ,  A61K45/06 ,  A61K9/00 ,  A61K9/10 ,  A61K31/498 ,  A61P3/10 ,  A61P11/00 ,  A61P31/04 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P35/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K9/146 ,  A61K9/1635

摘要： The present disclosure provides pharmaceutical compositions of niclosamide that may be administered either orally or by inhalation. These compositions may allow the achievement of a therapeutically effective dose of niclosamide to the lungs or the gastrointestinal tract. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.

公开(公告)号：WO2021199047A1

公开(公告)日：2021-10-07

申请号：PCT/IL2021/050366

申请日：2021-03-31

申请人： BIOMUSE LTD.

发明人： ROSENBERG, Eugene ,  ZILBER-ROSENBERG, Ilana ,  LEVY, Ophir

IPC分类号： A23L33/135 ,  A61K35/74 ,  C12N1/20 ,  A61K9/00 ,  A61P25/34 ,  A24B15/30 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  C12N1/205 ,  C12R2001/19 ,  C12R2001/41 ,  C12R2001/43

摘要： A method of treating or preventing a disease associated with smoke residue in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one agent which increases the amount of a bacterium which is capable of breaking down the smoke residue in the subject. Methods of alleviating the symptoms caused by withdrawal from the use of nicotine are also disclosed.

公开(公告)号：WO2022256024A1

公开(公告)日：2022-12-08

申请号：PCT/US2021/040860

申请日：2021-07-08

申请人： MOREHOUSE SCHOOL OF MEDICINE

发明人： BOND, Vincent, Craig ,  HUANG, Ming, Bo ,  LILLARD, James, W., Jr.

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  A61P11/00 ,  A61P31/12 ,  A61P31/14 ,  A61K38/00 ,  A61K45/06 ,  A61K47/542 ,  A61K47/60 ,  A61K9/0073 ,  A61K9/127 ,  C07K14/005 ,  C07K14/163 ,  C07K2319/07 ,  C07K2319/10 ,  C07K2319/35 ,  C07K2319/70 ,  C12N2740/16022 ,  C12N2740/16033

摘要： The present application relates to methods and compositions and methods for treating viral infections, especially those caused by SARS-CoV-2. In one aspect, a method of treatment comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising a multipartite SARS-CoV-2-inhibiting peptide comprising a secretion modulating region (VI-SMR) peptide from HIV-1 Nef in combination with a cell-penetrating peptide (CPP) domain, a Clusterin (Clu)-binding peptide (Clu-BP) domain, a mitochondrial targeting (Mito-T) peptide domain, an anti-fusogenic (AF) peptide domain, a viral attachment inhibitor (VAI) domain or combination thereof, optionally where the SARS-CoV-2-inhibiting peptide is pegylated and/or modified with one or more hydrophobic domains.

公开(公告)号：WO2021198328A1

公开(公告)日：2021-10-07

申请号：PCT/EP2021/058428

申请日：2021-03-31

申请人： BAYER AKTIENGESELLSCHAFT

发明人： UNGER, Florian ,  SCHNEID, Stefan, Christian ,  MOTZKUS, Hans-Walter ,  HAASBACH, Carina

IPC分类号： A61K47/60 ,  A61K9/00 ,  A61K9/19 ,  A61K38/22 ,  A61P11/08 ,  A61P9/08 ,  A61K38/00 ,  A61K9/0073

摘要： The present invention relates to novel pharmaceutical formulations, preferably for inhalation, comprising polyethylene glycol (PEG)-based prodrugs of Adrenomedullin (PEG-ADM) and the use thereof for the treatment and/or prevention of acute lung injury/acute respiratory distress syndrome (ALI/ARDS).

公开(公告)号：WO2021143962A1

公开(公告)日：2021-07-22

申请号：PCT/DE2020/100988

申请日：2020-11-21

申请人： JUNGHANS, Simon Frank ,  GROSS, Justus

发明人： JUNGHANS, Simon Frank ,  GROSS, Justus

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/48 ,  A61K9/51 ,  A61K9/70 ,  A61K35/00 ,  A61K47/46 ,  A61K35/76 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/0073 ,  A61K9/4875 ,  A61K9/5184 ,  A61K9/7007 ,  A61L17/005 ,  A61P17/02 ,  A61P31/04

摘要： Die Erfindung betrifft Bakteriophagen- Bereitstellungen, nämlich intracorporale Bakteriophagen- Bereitstellung, naso-pharyngeale und pulmonale Bakteriophagen-Bereitstellung, cutane Bakteriophagen-Bereitstellung und Bakteriophagen-Nahtmaterial-Bereitstellung sowie weiter eine Zwei-Spritzen-Bakteriophagen-Bereitstellung, eine naso-pharyngeale und pulmonale Bakteriophagen-Bereitstellungs-Vorrichtung sowie eine Bakteriophagen-Sensitive-Tester-Applikation.

公开(公告)号：WO2022241167A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/029074

申请日：2022-05-12

申请人： APPLIED MOLECULAR TRANSPORT INC. ,  MRSNY, Randall J.

发明人： HUNTER, Thomas Carl ,  MASUYER, Geoffrey ,  LIU, Keyi

IPC分类号： A61K38/00 ,  A61K38/27 ,  A61K47/64 ,  A61P5/06 ,  C12N9/10 ,  A61K9/00 ,  C07K14/195 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/28 ,  A61K9/0073 ,  A61K9/148

摘要： The present disclosure provides delivery constructs comprising a carrier derived from a mono-ADP-ribosyl transferase (mART). The mART can be from an Aeromonas, Chromobacterium, Collimonas, Shewanella, Janthinobacterium, Serratia, or Acinetobacter microorganism. The carrier contains a transcytosing element of the mART (typically Domain I) and is coupled to a heterologous payload. The carrier can be capable of transporting the payload across an intact polarized epithelium. The delivery construct can be part of a pharmaceutical composition that can be orally or nasally administered to a subject to provide for improved, effective therapies for treatment of various diseases.

公开(公告)号：WO2021198116A1

公开(公告)日：2021-10-07

申请号：PCT/EP2021/058047

申请日：2021-03-26

申请人： UNION THERAPEUTICS A/S

发明人： SOMMER, Morten ,  TOFT-KEHLER, Rasmus ,  TOFT-KEHLER, Anne, Katrine ,  DITZINGER, Günter ,  JELLINGSOE, Mads ,  ANDRES, Philippe ,  KNOPP, Matthias, Manne

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/609 ,  A61K47/40 ,  A61P31/00 ,  A61P31/04 ,  A61P31/14 ,  A61P31/16 ,  A61P11/00 ,  A61P11/06 ,  A61P27/02 ,  A61K9/0073

摘要： The invention relates to formulations comprising a halogenated salicylanilide, or a pharmaceutically acceptable salt thereof, and a cyclodextrin. The formulations may be in the form of a liquid formulation, particularly an aqueous formulation, and provide high concentrations of solubilised halogenated salicylanilide. Also disclosed a formulations in the form of powders and aerosols. Also disclosed are the formulations for use in the treatment of bacterial and viral infections, and the treatment of inflammatory diseases. The formulations are particularly suitable for administration by inhalation for the treatment of bacterial and viral pulmonary infections and the treatment of pulmonary inflammatory diseases.

公开(公告)号：WO2021195017A1

公开(公告)日：2021-09-30

申请号：PCT/US2021/023574

申请日：2021-03-23

申请人： IOCURE, INC.

发明人： FARB, Mark Daniel

IPC分类号： A61K9/00 ,  A61K33/18 ,  A61K45/06 ,  A61P31/04 ,  A61P31/06 ,  A61P31/10 ,  A61P31/12 ,  A61P31/14 ,  A61K2300/00 ,  A61K31/4706 ,  A61K9/007 ,  A61K9/0073 ,  A61K9/0078 ,  A61M11/042 ,  A61M16/024 ,  A61M16/109 ,  A61M16/14 ,  A61M16/202 ,  A61M2016/1035 ,  A61M2202/0468 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/18 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/502 ,  A61P11/00

摘要： Provided herein are compositions, methods, uses, and articles of manufacture for iodine treatment on mucosal membranes, and treatment of respiratory pathogens in this way—e.g., by inhalation and combined with the evaporation of steam. In certain embodiments, iodine treatment encompasses administration of compounds that release molecular iodine and/or physiologically active iodine-containing compounds.