公开(公告)号：WO2021257387A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/036917

申请日：2021-06-11

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  BROWN, Matthew Robert ,  GODFREY, Scott A. ,  KWONG, Aaron Thomas

Inventor： BROWN, Matthew Robert ,  GODFREY, Scott A. ,  KWONG, Aaron Thomas

IPC: B01F5/06 ,  B01F5/10 ,  C12M1/00 ,  B01F25/4331 ,  B01F25/50 ,  B01F25/51 ,  C07K1/145

Abstract: A device and method for in-line homogenizing a non-uniform feed stream is described herein, which includes a plug flow reactor (PFR), a bypass line, and a pump in a closed-circuit flow path that allows for rapid homogenization of the non-uniform feed stream.

公开(公告)号：WO2023059657A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/045696

申请日：2022-10-04

Applicant: WEST PHARMACEUTICAL SERVICES, INC.

Inventor： LEE, Claudia ,  SULLIVAN, Michael ,  KUMAR, Rajiv ,  DELVECCHIO, Daniel E. ,  GUTHLEIN, James

IPC: B01F25/433 ,  A61J1/2062 ,  A61J1/2096 ,  A61K47/6929 ,  B01F2101/22 ,  B01F23/405 ,  B01F23/45 ,  B01F25/4331 ,  B01F33/301 ,  B01F35/75425 ,  B01F35/75465

Abstract: An adapter for connecting one or more storage containers with a syringe is described. The adapter includes a first port that provide a connection with a first container volume, a second port that provides a connection with a second container volume, a third port that provides a connection to a syringe. The adapter further includes a mixing channel extending from a first end in fluid communication with the third port to a second end. The mixing channel includes a tortuous path along at least a portion of its length. The mixing channel enables two constituents of a pharmaceutical complex to be mixed through the mixing channel to form the pharmaceutical complex. Also disclosed is a system including such an adapter, a method of mixing two constituents of a pharmaceutical complex via such an adapter and a method of manufacturing such an adapter.

公开(公告)号：WO2022271382A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/030670

申请日：2022-05-24

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： GRITTI, Fabrice

IPC: B01F33/30 ,  B01F25/432 ,  B01F25/433 ,  B01F2101/2204 ,  B01F25/4323 ,  B01F25/4331 ,  G01N2030/027 ,  G01N2030/347 ,  G01N30/02 ,  G01N30/34

Abstract: Described is a mixer for a liquid chromatography system. The mixer (58) includes an inlet (42), an outlet (50), a first flow channel (44B), and a second flow channel (44A). The inlet receives a fluid flow to be mixed and the outlet provides the mixed fluid flow. Each of the two flow channels is coupled between the inlet and the outlet. The second flow channel includes an offset volume that delays fluid propagation through the second flow channel relative to the first flow channel. The offset volume includes a coiled channel (64) which increases radial dispersion and decreases axial dispersion of a fluid flowing through the offset volume, thereby enabling a further reduction in periodic noise in a detector baseline signal as compared to known split flow mixers for liquid chromatography systems.

公开(公告)号：WO2021255692A1

公开(公告)日：2021-12-23

申请号：PCT/IB2021/055376

申请日：2021-06-17

Applicant: MIROSŁAW SZUSTER, Szuster Consulting

Inventor： SZUSTER, Jolanta

IPC: B01F3/04 ,  B01F5/04 ,  B01F5/02 ,  B01F5/06 ,  B01F13/10 ,  B01F23/2323 ,  B01F25/21 ,  B01F25/3121 ,  B01F25/31233 ,  B01F25/31243 ,  B01F25/32 ,  B01F25/4331 ,  B01F33/811

Abstract: The object of the present invention is a method of mixing a liquid with a gas, in a gas-tight multi-tube reactor, and a device for mixing liquid with gas. The multi-tube reactor disclosed herein is used for mixing liquids, at least one of which is in a form of a gas or emits a gas, especially for introducing process gases into the liquids being treated, whether for oxygenating water or wastewater and sewage sludge. Furthermore, the multi-tube reactor according to the invention may be used in water treatment and wastewater disinfection technologies utilising ozone and/or hydrogen peroxide. It may also be used in existing wastewater treatment plants, as well as for the oxygenation of water in various bodies of water. The device is in a form of a multi-tube reactor provided with a main mixing chamber having a front part, a rear part, a bottom and a ceiling, wherein at least one propulsion injector nozzle, located at the bottom of the main mixing chamber, is introduced into the front part of the main mixing chamber, and an additional mixing chamber is led out of the rear part of the main mixing chamber, the additional mixing chamber having at least two times smaller cross-sectional area than the cross-sectional area of the main mixing chamber of the multi-tube reactor, characterised in that at the opposite end of the main mixing chamber (2), in the additional mixing chamber (5), a propulsion injector nozzle (3) is installed, directed with its tapering end towards the outlet from the additional mixing chamber (5), and from the ceiling (2.4) of the main mixing chamber (2), at least one bypass connection (6) is provided, which is connected at its other end to the additional mixing chamber (5).