公开(公告)号：WO2023064237A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/046219

申请日：2022-10-11

申请人： LEVITASBIO, INC. ,  LAZARUK, Kathy ,  STEVENS, Christopher ,  TRAVERS, Kevin

发明人： LAZARUK, Kathy ,  STEVENS, Christopher ,  TRAVERS, Kevin

IPC分类号： G01N33/569 ,  B03C1/32

摘要： Described are various embodiments of methods, devices, systems and kits for magnetic levitation-based separation of mixtures or populations of particles that include various types of particles. Some embodiments of such methods, devices, systems and kits are useful for magnetic levitation-based separation of mixtures or populations of cells that include various cell types. Some other embodiments of the described methods, devices, systems and kits are useful for magnetic levitation-based separation of mixtures or population of cellular or mixtures or population of biological molecules.

公开(公告)号：WO2022251936A1

公开(公告)日：2022-12-08

申请号：PCT/BR2022/050187

申请日：2022-05-31

申请人： RIBEIRO DOS SANTOS NOGUEIRA, Daniel

发明人： RIBEIRO DOS SANTOS NOGUEIRA, Daniel

IPC分类号： B22F1/00 ,  B22F9/16 ,  B03C1/01 ,  B03C1/32

摘要： Refere-se a presente invenção a uma melhoria na etapa de concentração magnética de partículas de minerais ou minérios por meio de um ou mais produto químico nanomagnético funcionalizado. Este produto pode ser aplicado de forma dosada diretamente na polpa (minério e água) com o objetivo de ser concentrado magneticamente aderido (seletivamente ou não) de forma eletrostática ou magnética às partículas minerais contidas na polpa de modo a incrementar susceptilidade magnética daquelas partículas expostas nas matrizes (9) às linhas de campo geradas em (2) e (3). O intuito é modificar durante a concentração magnética alguns parâmetros das partículas, sejam eles ambientais ou físicos, como por exemplo a susceptibilidade magnética e de química de superfície como por exemplo a atração eletrostática, isso executado de modo seletivo ou não, visando efeitos sobre as recuperações e teores de minerais e/ou minérios, sejam magnéticos e/ou não magnéticos.

公开(公告)号：WO2022034214A1

公开(公告)日：2022-02-17

申请号：PCT/EP2021/072598

申请日：2021-08-13

申请人： VECOR IP HOLDINGS LIMITED ,  VECOR CERAMIC TILES ITALIA S.R.L.

发明人： SEVERIN, Erik ,  FERNANDEZ, Erwin, N. ,  MISA, John, Vincent, Adap

IPC分类号： B07B1/00 ,  B07B15/00 ,  B03B9/04 ,  B03C1/32 ,  C04B14/00 ,  C08K3/013 ,  C08K9/00 ,  C04B18/08

摘要： The present invention relates to a process for preparing whitened fly ash, wherein the process comprises the steps of: (a) subjecting fly ash to a size classification step to obtain size classified fly ash having a particle size such that at least 90wt% has a particle size of from 44µm to 250µm; (b) optionally, contacting the size classified fly ash from step (a) with water so as to form a slurry, wherein the slurry has a solid content of less than 40wt%; (c) subjecting the slurry obtained in step (b) to an exhaustive magnetic separation step to form magnetically treated fly ash, wherein the exhaustive magnetic separation step comprises a first magnetic extraction step and a second magnetic extraction step, wherein the second magnetic extraction step is carried out at a higher magnetic field strength than the first magnetic extraction step; and (d) subjecting the magnetically treated fly ash obtained in step (c) to a milling step to form whitened fly ash.

公开(公告)号：WO2018184002A1

公开(公告)日：2018-10-04

申请号：PCT/US2018/025669

申请日：2018-04-02

申请人： BIOMAGNETIC SOLUTIONS LLC

发明人： LIBERTI, Paul, A., Ph.D

IPC分类号： B03C1/02 ,  B03C1/32 ,  G01N33/53 ,  G01N33/543

摘要： This invention relates to the static or continuous magnetic separation of specific entities from mixtures where the separation of target entities is clone in a one-step process. It is universally applicable to the harvest or removal of such entities for processing of biological molecules, cells of ail types, virus particles, and the like, and for small- to large-scale separations of the same. By manipulation of the scientific principles that underlie this invention, specific targets can be conveniently captured for analysis, harvested or subjected to further processing on a collection surface free of bystander components. The principles employed and the methods disclosed completely obviate the need for washing of targeted entities such as cycles of resuspension and magnetic separation for removal of contaminating substances in the case of static separation or complex cycles of sample introduction and harvest to perform continuous processing.

公开(公告)号：WO2018129789A1

公开(公告)日：2018-07-19

申请号：PCT/CN2017/074332

申请日：2017-02-22

申请人： 中国科学院过程工程研究所

发明人： 杨良嵘 ,  董婷婷 ,  邢慧芳 ,  于杰淼 ,  戎猛 ,  刘会洲

IPC分类号： B03C1/32

摘要： 全流程连续化气助磁分离系统，包括吸附罐(1)，吸附罐(1)连接有萃取塔(2)，萃取塔(2)连接有解吸塔(3)；萃取塔(2)和解吸塔(3)均包括中空的气浮柱(7)，气浮柱(7)的顶部均设有磁辊(8)，磁辊(8)的一侧设有刮板(9)，气浮柱(7)的底部均设有气体入口；萃取塔(2)和解吸塔(3)的气浮柱(7)均连接有冲洗装置，冲洗装置的冲洗口与刮板(9)相对设置。

公开(公告)号：WO2018098440A1

公开(公告)日：2018-05-31

申请号：PCT/US2017/063298

申请日：2017-11-27

申请人： INCELLDX, INC. ,  PATTERSON, Bruce K. ,  CHARGIN, Amanda Noel ,  SUBRAMANIAM, Srividyabhuvaneswari ,  RADNEDGE, Lyndsay

发明人： PATTERSON, Bruce K. ,  CHARGIN, Amanda Noel ,  SUBRAMANIAM, Srividyabhuvaneswari ,  RADNEDGE, Lyndsay

IPC分类号： B01L3/00 ,  B01L99/00 ,  B03C1/32 ,  G01N33/48 ,  G01N33/487

摘要： Human immunodeficiency virus (HIV) phenotyping assays are provided. Such assays may be used in identifying a phenotype of an HIV virion and find use in HIV susceptibility testing as well as other purposes. Methods employing HIV phenotyping assays are also provided including methods that involve the use of target cells contacted with the HIV virion for generating infected cells and/or assessing infection. Also provided are cells that may be contacted with HIV as part of such an assay, methods of infecting cells with HIV, methods of detecting HIV and methods of evaluating a cellular sample for an HIV infection. Methods of treating a subject based on the result of an assay of the present methods, as well as kits and compositions for use in practicing the herein described methods are also provided.

公开(公告)号：WO2018089760A1

公开(公告)日：2018-05-17

申请号：PCT/US2017/061048

申请日：2017-11-10

申请人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC. ,  GHIRAN, Ionita, C. ,  SHAPIRO, Nathan ,  SHARDA, Anish, V. ,  FELTON, Edward, J.

发明人： GHIRAN, Ionita, C. ,  SHAPIRO, Nathan ,  SHARDA, Anish, V. ,  FELTON, Edward, J.

IPC分类号： B03C1/00 ,  B03C1/32 ,  G01N9/36 ,  G01N33/50

摘要： Methods and apparatus for detecting cell-bound and soluble antigens in a biological sample are described. The method comprises forming complexes of at least one antibody-coated bead and at least one antigen in a solution, placing the solution in a magnetic field such that the formed complexes levitate in the solution at a particular height, and determining at least one characteristic of the antigen in the complexes based, at least in part, on an image of the complexes showing the magnetic levitation height.

摘要翻译： 描述了用于检测生物样品中细胞结合和可溶抗原的方法和装置。 该方法包括在溶液中形成至少一种抗体包被的珠子和至少一种抗原的复合物，将该溶液置于磁场中，使得形成的复合物在溶液中悬浮在特定高度，并且确定至少一个 复合物中的抗原至少部分基于显示磁悬浮高度的复合物的图像。

公开(公告)号：WO2018057961A9

公开(公告)日：2018-03-29

申请号：PCT/US2017/053064

申请日：2017-09-22

申请人： ARCHERDX, INC.

发明人： STAHL, Joshua ,  MYERS, Jason

IPC分类号： B03C1/00 ,  B03C1/02 ,  B03C1/32 ,  G01N1/34

摘要： An apparatus comprising a magnetic assembly and methods for operating the apparatus are provided. The magnetic assembly may be used to manipulate molecules in a liquid preparation, for example to isolate or separate the molecules from the liquid. The magnetic assembly may be used to wash and/or isolate nucleic acid molecules of interest from a liquid preparation.

公开(公告)号：WO2010091874A1

公开(公告)日：2010-08-19

申请号：PCT/EP2010/000879

申请日：2010-02-12

申请人： ASOCIACIÓN-CENTRO DE INVESTIGACIÓN COOPERATIVA EN NANOCIENCIAS - CIC NANOGUNE ,  BERTACCO, Riccardo ,  CANTONI, Matteo ,  DONOLATO, Marco ,  GOBBI, Marco

发明人： BERTACCO, Riccardo ,  CANTONI, Matteo ,  DONOLATO, Marco ,  GOBBI, Marco

IPC分类号： B03C1/32

CPC分类号： B03C1/32 ,  B03C2201/18 ,  Y10T137/0391 ,  Y10T137/206

摘要： A system and a method for the controlled manipulation of any number of magnetic particles in solution are shown. The system and the method of the present invention are based on the employment of magnetic conduits properly structured in order to inject, move and annihilate with high precision magnetic domain walls and on the fact that said magnetic domain walls exert a high attraction force on magnetic particles. The injection, movement and annihilation of domain walls along said magnetic conduit result, therefore, in the trapping, movement and release, respectively, of single magnetic particles placed in solution in proximity of said magnetic conduits. The devices of the present invention guarantee the possibility of a digital transfer of magnetic particles along conduits formed by linear segments as well as high control and nanometric precision in the manipulation of said magnetic particles on curved conduits.

摘要翻译： 示出了用于在溶液中控制任何数量的磁性颗粒的系统和方法。 本发明的系统和方法基于使用适当构造以便用高精度磁畴壁注入，移动和消除的磁导管，以及所述磁畴壁对磁性颗粒施加高吸引力的事实 。 因此，沿着磁导管的畴壁的注入，移动和湮灭导致分别在放置在所述磁导管附近的溶液中的单个磁性颗粒的捕获，移动和释放。 本发明的装置保证磁性颗粒沿着由线性段形成的导管的数字传输以及在弯曲管道上操纵所述磁性颗粒的高控制和纳米精度的可能性。

公开(公告)号：WO2009108047A1

公开(公告)日：2009-09-03

申请号：PCT/NL2009/050016

申请日：2009-01-16

申请人： TECHNISCHE UNIVERSITEIT DELFT ,  REM, Peter, Carlo ,  BERKHOUT, Simon, Peter, Maria

发明人： REM, Peter, Carlo ,  BERKHOUT, Simon, Peter, Maria

IPC分类号： B03C1/01 ,  B03C1/32

CPC分类号： B03B5/44 ,  B03B5/30 ,  B03C1/01 ,  B03C1/0335 ,  B03C1/288 ,  B03C1/32 ,  B03C2201/18 ,  B03C2201/20

摘要： The invention relates to a method and apparatus for separating solid particles of different densities, using a magnetic process fluid. The solid particles are thoroughly mixed in a small partial flow of the process fluid. The small turbulent partial flow is added to a large laminar partial flow of the process fluid, after which the obtained mixture of the respective partial process fluids is conducted over, under, or through the middle of two magnetconfigurations, wherein the particles are separated into lighter particles at the top of the laminar process fluid and heavier particles at the bottom of the laminar process fluid, each of which are subsequently removed with the aid of a splitter. After that furthermore the particles of low density and the particles of high density are separated from the respective process streams, dried and stored. Finally, the process fluid from which the particles have been removed is returned to the original starting process stream. The method according to the invention is especially suitable, for example, for separating a mixture of polypropylene particles and polyethylene particles.

摘要翻译： 本发明涉及使用磁性工艺流体分离不同密度的固体颗粒的方法和装置。 固体颗粒在过程流体的小部分流动中充分混合。 将小的湍流部分流加入到工艺流体的大的层流部分流中，之后将各个部分工艺流体的所得混合物在两个磁体构造的中间或之下进行，其中颗粒被分离成更轻的 在层流过程流体顶部的颗粒和层流过程流体底部的较重颗粒，随后借助分离器将其中的每一个除去。 此后，将低密度颗粒和高密度颗粒与各个工艺流分离，干燥并储存。 最后，将颗粒从其中除去的工艺流体返回原始的起始工艺流程。 根据本发明的方法特别适用于例如分离聚丙烯颗粒和聚乙烯颗粒的混合物。