BUTYRATE AND BETA-HYDROXYBUTYRATE COMPOSITIONS AND METHODS OF USE THEREOF

    公开(公告)号:WO2018187852A1

    公开(公告)日:2018-10-18

    申请号:PCT/CA2017/050646

    申请日:2017-05-29

    Inventor: CAVALERI, Franco

    Abstract: Compositions and methods for providing a person with an exogenous and therapeutically effective supply of ketones are disclosed. The compositions may consist essentially of (a) purified butyrate (or esters or propionate salts thereof) and (b) purified beta-hydroxybutyrate (or esters or propionate salts thereof). The compositions may further include other pharmacologically active agents, such as acetyl-L carnitine, R- alpha lipoic acid, green tea extract, vitamins, and various combinations of such agents. The methods include providing a person with an exogenous supply of ketones, by orally administering a pharmacologic composition, which is effective to deliver 2000 - 5000 mg of a short chain fatty acid (e.g., butyrate) and 5000 - 10,000 mg of ketone (e.g., beta- hydroxybutyrate) on a daily basis. In addition, methods for increasing nuclear factor erythroid 2 related factor 2 (Nrf2) levels in a group of cells are disclosed, which involve the administration of the compositions described above to the group of cells.

    PROCESSES FOR PREPARING OXYGENATES AND CATALYSTS THEREFOR
    10.
    发明申请
    PROCESSES FOR PREPARING OXYGENATES AND CATALYSTS THEREFOR 审中-公开
    制备氧化剂和催化剂的方法

    公开(公告)号:WO99038836A1

    公开(公告)日:1999-08-05

    申请号:PCT/US1999/002024

    申请日:1999-01-28

    Abstract: This invention relates in part to processes and catalysts for the conversion of a feedstock comprising carbon monoxide and hydrogen to a product stream comprising at least one of an ester, acid, acid anhydride and mixtures thereof. This invention also relates in part to processes and catalysts for converting an alcohol, ether and/or ether alcohol feedstock to oxygenated products, e.g., esters, acids, acid anhydrides and mixtures thereof. The processes and catalysts are especially suitable for the production of acetic acid and methyl acetate from a synthesis gas feedstock or from an alcohol, ether or ether alcohol feedstock.

    Abstract translation: 本发明部分涉及用于将包含一氧化碳和氢的原料转化成包含酯,酸,酸酐及其混合物中的至少一种的产物流的方法和催化剂。 本发明还部分涉及用于将醇,醚和/或醚醇原料转化为氧化产物,例如酯,酸,酸酐及其混合物的方法和催化剂。 该方法和催化剂特别适用于从合成气原料或醇,醚或醚醇原料生产乙酸和乙酸甲酯。

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