公开(公告)号：WO2022265043A1

公开(公告)日：2022-12-22

申请号：PCT/JP2022/023976

申请日：2022-06-15

Applicant: 富士フイルム株式会社

Inventor： 金澤　吉憲 ,  渡辺　康介 ,  田中　宏明 ,  中田　飛翼 ,  ▲濱▼田　直佳 ,  込山　和興 ,  川井　一輝

IPC: C09K11/06 ,  C09B23/01 ,  C09B23/14 ,  G01N33/533 ,  G01N33/58 ,  G01N21/64

Abstract: 下記式（１）の化合物、これを有する標識生体物質。　環Ｚ１及び環Ｚ２は、炭素原子及び窒素原子から選択される環構成原子で形成される６員環を示す。　Ｒ１～Ｒ４、Ｒ１１～Ｒ１３、Ｌ１、Ｌ２は特定の基を示し、ｎ、α１、α２は特定の数を示す。　Ｒ１１～Ｒ１３の少なくとも１つはカルボキシ基又は生体物質に結合可能な置換基を含む。　式（１）で表される化合物は、少なくとも１つの－（ＣＨ２－ＣＨ２－Ｏ）ｍ－Ｒ２１で表される構造を有する。Ｒ２１は特定の基を示し、ｍは特定の数を示す。　式（１）で表される化合物は中性の化合物である。

公开(公告)号：WO2022233795A1

公开(公告)日：2022-11-10

申请号：PCT/EP2022/061723

申请日：2022-05-02

Applicant: ILLUMINA CAMBRIDGE LIMITED

Inventor： CALLINGHAM, Michael ,  ROMANOV, Nikolai Nikolaevich ,  LIU, Xiaohai ,  PIEKOS, Justyna

IPC: C07F5/02 ,  A61K31/196 ,  A61K41/00 ,  A61K47/54 ,  C09B23/01 ,  C09B23/04 ,  C09B23/12 ,  C09B57/00

Abstract: The present application relates to substituted dyes containing bis-boron fused heterocycles and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

公开(公告)号：WO2021215514A1

公开(公告)日：2021-10-28

申请号：PCT/JP2021/016361

申请日：2021-04-22

Applicant: 富士フイルム株式会社

Inventor： 金澤　吉憲 ,  藤原　良 ,  白兼　研史 ,  渡辺　康介 ,  荒井　雄輝 ,  込山　和興 ,  田中　宏明

IPC: C07D403/14 ,  C07D471/04 ,  C07D487/22 ,  C07D498/22 ,  A61K49/00 ,  C09B23/01 ,  G01N33/58

Abstract: 下記式（１）の化合物、これを有する標識生体物質。　Ｚ１、Ｚ２は特定の６員環を示す。但し、Ｚ１、Ｚ２の少なくとも一方は、Ｌ１もしくはＬ２が結合する窒素原子に対してオルト位に特定の置換基を有するベンゼン環、又は、上記オルト位に位置する環構成原子が窒素原子である特定の含窒素６員環である。　Ｒ１～Ｒ４、Ｒ１１～Ｒ１３、Ｌ１、Ｌ２、Ｒ２１は特定の基を示し、ｎ、α１、α２、ｍは特定の数を示す。　上記化合物は、－（ＣＨ２－ＣＨ２－Ｏ）ｍ－Ｒ２１で表される構造を複素環上に少なくとも１つ有し、カルボキシ基又は生体物質に結合可能な置換基を特定の位置に少なくとも１つ有し、Ｚ１、Ｚ２の少なくとも一方が上記特定の含窒素６員環である場合、特定の置換基同士が結合して環を形成していてもよい。

公开(公告)号：WO2020041743A1

公开(公告)日：2020-02-27

申请号：PCT/US2019/047972

申请日：2019-08-23

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： BANDI, Venu G. ,  SCHNERMANN, Martin J.

IPC: C09B23/01 ,  A61K31/404 ,  C07D417/08 ,  G01N33/483

Abstract: Cyanine fluorophores including a nine-carbon polymethine bridge are disclosed. The cyanine fluorophores have absorbance and/or emission maxima in the near-infrared (NIR) and short-wave infrared (SWIR) wavelength ranges. Methods of making and using the cyanine fluorophores are also disclosed. The compounds are useful in fluorescence imaging, more particularly in cancer treatment. The compounds have generic formula (I):

公开(公告)号：WO2020020905A1

公开(公告)日：2020-01-30

申请号：PCT/EP2019/069834

申请日：2019-07-23

Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

Inventor： VENDRELL, Marc ,  FERNANDEZ, Antonio ,  MELLANBY, Richard ,  SCOTT, Jamie ,  MAIR, Iris ,  GUZMAN, Claudia, Garcia ,  DHILLON, Baljean ,  BAGNANINCHI, Pierre

IPC: C09B23/01 ,  C07D403/14

Abstract: The present invention provides a tricarbocyanine N -triazoles family of bright, photostable and cell- permeable NIR chromophores containing neutral triazole groups. In particular, a compound of formula (I), a derivative or a salt thereof is provided. Formula (I) wherein, R1 is absent or selected from the group consisting C1-C6 alkyl, and C1-C9 alkyl substituted with one or more of the following groups: halogen, hydroxyl, aryl, carboxylic acids; C3-C6 cycloalkyl, aryl groups substituted with one or more of the following groups: alkyl, cycloalkyl, naphthalenyl, phenanthrenyl, amino, aminoalkyl, aminocycloalkyl, formyl, trifluoromethyl, carboxyl, halogen, hydroxyl, hydroxyalkyl, alkyloxy, hydroxyaryl, nitro; thiophenyl, pyridinyl, imidazolyl, acetal, benzyl; R2 and R3 are each independently selected from the group consisting of C1-C6 alkyl, and C1-C6 alkyl substituted with one or more of the following groups: carboxylic acids, substituted amides, sulphonate groups, aryl, succinimidyl esters, maleimides, polyethyleneglycol-based substituents; R4, R5, R8 and R9 are each independently absent, C1-C6 alkyl or H; R6 and R10 are each independently H; R7 and R11 are each independently selected from the group consisting of H, Me and sulphonate; or R6-R7 and/or R10-R11 form an aromatic ring and/or R5-R6 and/or R9-R10 form an aromatic ring; R12 is selected from the group consisting of H, C1-C6 alkyl, and C1-C9 alkyl substituted with one or more of the following groups: hydroxyl, aryl, carboxylic esters, carboxylic acids; amine, aminoalkyl, aminocycloalkyl, aminoaryl, tosyl, hydroxyalkyl, hydroxyaryl, thioalkyl, thioaryl; X and Y are each independently selected from the group consisting of C, S, O and N; and Z is either C or N. The invention further relates to processes for the preparation of the compounds, and uses of the compounds in therapeutic, diagnostic, surgery and analytical applications.

公开(公告)号：WO2016085884A1

公开(公告)日：2016-06-02

申请号：PCT/US2015/062212

申请日：2015-11-23

Applicant: LI-COR, INC.

Inventor： DRANEY, Daniel, R. ,  VOLCHECK, William, M. ,  SCHAEPE, Katie ,  ELITZIN, Vassil ,  KOVAR, Joy

IPC: A61K49/00 ,  C09B23/01

CPC classification number: A61K49/0032 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/20 ,  A61B5/4244 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/086 ,  C09B23/107

Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4- sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3- dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3- dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4- sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1- ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

Abstract translation: 一种器官成像方法，其特征在于，包括：向患者施用诊断有效量的2 - （（E）-2 - （（E）-3-（2 - （（E）-3,3-二甲基-5-磺酸 -1-（4-磺酰基丁基）二氢吲哚-2-亚基）亚乙基）-2-苯氧基环己-1-烯-1-基）乙烯基）-3,3-二甲基-1-（4-磺酰基丁基） 1 - （ - ） - （（E）-2 - （（E）-3-（2 - （（（E））-3,3-二甲基-5-磺酸酯基 - （4-磺酰基丁基） 亚乙基）亚乙基）-2-（4-磺酰苯氧基）环己-1-烯-1-基）乙烯基）-3,3-二甲基-1-（4-磺酰基丁基）-3H-吲哚-1-基 - -5-磺酸酯。 在一个实施方案中，器官包括肾，膀胱，肝，胆囊，脾，肠，心脏，肺和肌肉中的一种或多种。

公开(公告)号：WO2014078140A1

公开(公告)日：2014-05-22

申请号：PCT/US2013/068662

申请日：2013-11-06

Applicant: EASTMAN KODAK COMPANY

Inventor： SAVARIAR-HAUCK, Celin ,  HEINRICH, Martin

IPC: G03F7/029 ,  B41C1/10 ,  G03F7/105 ,  G03F7/30 ,  C09B23/01

CPC classification number: G03F7/004 ,  B41C1/1008 ,  C09B23/0008 ,  C09B23/0066 ,  C09B23/08 ,  G03F7/029 ,  G03F7/105 ,  G03F7/3035

Abstract: A negative-working lithographic printing plate precursor is used for making lithographic printing plates from infrared radiation imaging. The precursor comprises free radical chemistry and a specific infrared radiation absorber that is a cyanine dye and defined by Formula (1a) described in the disclosure. This particular infrared radiation absorber provides both IR sensitivity and print out after imaging.

Abstract translation: 使用负性平版印刷版原版从红外线成像制造平版印刷版。 前体包括自由基化学和特定的红外辐射吸收剂，其是花青染料并且由本公开内容中描述的式（1a）定义。 这种特殊的红外线辐射吸收器既提供IR灵敏度又能在成像后打印出来。

公开(公告)号：WO2013144177A1

公开(公告)日：2013-10-03

申请号：PCT/EP2013/056461

申请日：2013-03-27

Applicant: BASF SE ,  BASF SCHWEIZ AG

Inventor： SEND, Robert ,  BRUDER, Ingmar ,  ERK, Peter ,  SENS, Rüdiger ,  YAMAMOTO, Hiroshi ,  YAMATO, Hitoshi ,  NAKAMICHI, Shinji ,  TAKAHASHI, Ryuichi

IPC: C09B23/10 ,  C09B69/06 ,  H01G9/20 ,  H01L51/00 ,  C09B23/00 ,  C09B23/14 ,  C09B57/00 ,  C09B23/01

CPC classification number: H01L51/0072 ,  C09B23/0091 ,  C09B23/105 ,  C09B23/148 ,  C09B57/008 ,  C09B69/06 ,  C09K11/06 ,  C09K2211/1014 ,  C09K2211/1018 ,  H01G9/2031 ,  H01G9/2059 ,  H01L51/0059 ,  H01L51/0064 ,  Y02E10/542 ,  Y02E10/549

Abstract: The present invention relates to an electrode layer comprising a porous film made of oxide semiconductor fine particles sensitized with a quinolinium dye having a fluorinated counteranion. Moreover the present invention relatesto a photoelectric conversion device comprising said electrode layer, a dye sensitized solar cell comprising said photoelectric conversion device and to novel quinolinium dyes having a fluorinated counteranion.

Abstract translation: 本发明涉及一种电极层，其包括由具有氟化抗衡阴离子的喹啉染料敏化的氧化物半导体微粒制成的多孔膜。 此外，本发明涉及包括所述电极层，包含所述光电转换装置的染料敏化太阳能电池和具有氟化抗衡阴离子的新型喹啉染料的光电转换装置。

公开(公告)号：WO2009037325A2

公开(公告)日：2009-03-26

申请号：PCT/EP2008/062479

申请日：2008-09-18

Applicant: L'OREAL ,  GREAVES, Andrew ,  DAUBRESSE, Nicolas

Inventor： GREAVES, Andrew ,  DAUBRESSE, Nicolas

IPC: C09B23/10 ,  A61K8/49 ,  A61Q5/10 ,  C09B49/12 ,  C09B23/01 ,  A61K8/46

CPC classification number: A61K8/4933 ,  A61K2800/434 ,  A61Q5/065 ,  C09B23/105 ,  C09B62/78

Abstract: The invention relates to the dyeing of keratin materials using thiol and disulfide, indole-derived, styryl fluorescent dyes. The invention relates to a dye composition comprising thiol and disulfide, indole-derived, styryl fluorescent dyes and to a dyeing process with a lightening effect on keratin materials, in particular keratin fibers, especially human keratin fibers such as the hair, using said composition. It similarly relates to novel thiol and disulfide, indole-derived, styryl fluorescent dyes and to the uses thereof in lightening keratin materials. This composition makes it possible to obtain a lightening effect which is particularly resistant and visible on dark keratin fibers.

Abstract translation: 本发明涉及使用硫醇和二硫键，吲哚衍生的苯乙烯基荧光染料染色角蛋白材料。 本发明涉及包含硫醇和二硫键，吲哚衍生的苯乙烯基荧光染料的染料组合物，以及使用所述组合物对角蛋白材料，特别是角蛋白纤维，特别是人角蛋白纤维如头发的减轻作用的染色方法。 它同样涉及新型硫醇和二硫键，吲哚衍生的苯乙烯基荧光染料及其在减轻角蛋白材料中的用途。 该组合物使得可以获得在黑色角蛋白纤维上特别耐受和可见的减轻效果。

公开(公告)号：WO2005089813A3

公开(公告)日：2006-08-17

申请号：PCT/US2005007429

申请日：2005-03-09

Applicant: MALLINCKRODT INC ,  ACHILEFU SAMUEL ,  RAJAGOPALAN RAGHAVAN ,  DORSHOW RICHARD B ,  BUGAJ JOSEPH E ,  PERIASAMY MUTHUNADAR P

Inventor： ACHILEFU SAMUEL ,  RAJAGOPALAN RAGHAVAN ,  DORSHOW RICHARD B ,  BUGAJ JOSEPH E ,  PERIASAMY MUTHUNADAR P

IPC: A61K49/00 ,  A61K41/00 ,  A61K51/00 ,  C07D209/12 ,  C07D405/14 ,  C07F5/00 ,  C07K14/47 ,  C07K16/46 ,  C09B23/01 ,  C09B23/08

CPC classification number: A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056 ,  C07D209/12 ,  C07D405/14 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/08 ,  C09B23/086

Abstract: Cyanine dyes, as well as bioconjugates thereof, useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologues. Dyes of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1,300 nm; the exact range being dependent upon the particular dye. The use of a biocompatible organic solvent such as dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

Abstract translation: 公开了可用于诊断成像和治疗的花青染料及其生物缀合物。 缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。 本发明的染料可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的传递。 各种染料在350至1300nm的范围内是有用的; 精确的范围取决于特定的染料。 使用生物相容性有机溶剂如二甲基亚砜有助于维持化合物的荧光。 本发明的化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗。