公开(公告)号：WO2005039500A3

公开(公告)日：2009-04-02

申请号：PCT/US2004035219

申请日：2004-10-25

Applicant: UNIV CALIFORNIA ,  FENICAL WILLIAM H ,  JENSEN PAUL R ,  MINCER TRACY

Inventor： FENICAL WILLIAM H ,  JENSEN PAUL R ,  MINCER TRACY

IPC: C12N1/20 ,  A61K31/7048 ,  A61K35/74 ,  C07D321/00 ,  C07H17/08 ,  C12P1/00 ,  C12P1/06 ,  C12P19/62 ,  C12P21/04

CPC classification number: C07D321/00 ,  A61K31/7048 ,  C07H17/08 ,  C12P1/06 ,  C12R1/01

Abstract: The present invention provides methods for the isolation of a new group of actinomycetes and for the identification of members of this group based on characteristic nucleotide sequences and phylogenetic analyses. This group is phylogenetically distinct from all other known actinomycetes and represents a novel genus that includes multiple new species. Members of this group can be recognized by signature MAR2 nucleotides present in their 16S rRNA gene sequences and by standard phylogenetic treeing methods.

Abstract translation: 本发明提供了基于特征性核苷酸序列和系统发育分析来分离新组放线菌和鉴定该组成员的方法。 该组与所有其他已知的放线菌在系统发育上是不同的，并且代表一种包括多种新物种的新颖属。 该组的成员可以通过其16S rRNA基因序列中存在的签名MAR2核苷酸和标准系统发育树方法来识别。

公开(公告)号：WO2005025490A3

公开(公告)日：2007-11-01

申请号：PCT/US2004019916

申请日：2004-06-21

Applicant: UNIV CALIFORNIA ,  FENICAL WILLIAM H ,  JENSEN PAUL R ,  KWON HAK CHEOL

Inventor： FENICAL WILLIAM H ,  JENSEN PAUL R ,  KWON HAK CHEOL

IPC: C07H17/08 ,  A61K31/665 ,  A61K31/70 ,  A61K31/7048 ,  A61K45/06 ,  C07D321/00 ,  C12N1/20 ,  C12P1/06 ,  C12P17/08

CPC classification number: C12P1/06 ,  A61K31/7048 ,  A61K45/06 ,  C07D321/00 ,  C07H17/08 ,  C12N1/20 ,  C12P17/08 ,  C12R1/01

Abstract: A novel family of cyclic polyene natural products isolated from marine actinomycete strain CNQ 140 is provided. This novel strain of actinomycetes was obtained from a previously unstudied population of marine actinomycetes that reside in sediments off La Jolla, California. Compounds derived from strain CNQ 140 have been characterized as having a cyclic polyene-polyol structure; a molecular weight from about 996 to about 1010 in the core ring structure; and at least 58 carbons and at least 14 oxygens. The invention compounds have antitumor and/or anti-microbial activity.

Abstract translation: 提供了从海洋放线菌株CNQ 140中分离的环状多烯天然产物的新家族。 这种新型放线菌菌株是从加利福尼亚州拉霍亚（La Jolla）沉积物中存在的海洋放线菌以前未经研究的群体获得的。 衍生自应变CNQ 140的化合物已被表征为具有环状多烯 - 多元醇结构; 核心环结构中分子量约996至约1010; 和至少58个碳和至少14个氧。 本发明化合物具有抗肿瘤和/或抗微生物活性。

公开(公告)号：WO2006111743A9

公开(公告)日：2007-04-05

申请号：PCT/GB2006001429

申请日：2006-04-20

Applicant: PLANT BIOSCIENCE LTD ,  DODD HELEN ,  GASSON MICHAEL JOHN ,  MAYER MELINDA ,  NARBAD ARJAN

Inventor： DODD HELEN ,  GASSON MICHAEL JOHN ,  MAYER MELINDA ,  NARBAD ARJAN

IPC: C12Q1/68 ,  C07K14/355 ,  C07K14/36 ,  C12P1/06

CPC classification number: C07K14/36 ,  C12Q1/689

Abstract: This invention provides a method for discovery of new lantibiotic pathways by mining available sequence information and by exploiting conserved regions in lantibiotic biosynthetic enzymes to design probes and PCR primers for analysis of un-studied organisms. We have found that lantibiotic biosynthetic enzymes are broadly distributed in Gram-positive. New pathways are being cloned and sequenced and their lantibiotic products are being defined and disclosed.

Abstract translation: 本发明提供了一种通过挖掘可获得的序列信息和通过利用羊毛硫抗生素生物合成酶中的保守区域来设计探针和PCR引物来分析未研究的生物体的方法来发现新的羊毛硫抗生素途径。 我们发现羊毛硫素生物合成酶广泛分布在革兰氏阳性菌中。 正在克隆和测序新的途径，并且定义和披露其羊毛硫抗生素产品。

公开(公告)号：WO2006052787A3

公开(公告)日：2006-08-31

申请号：PCT/US2005040098

申请日：2005-11-04

Applicant: NOVOZYMES NORTH AMERICA INC ,  ICM INC ,  BHARGAVA SWAPNIL ,  KOHL SCOTT DENNIS

Inventor： BHARGAVA SWAPNIL ,  KOHL SCOTT DENNIS

IPC: A61K38/43 ,  A61K38/46 ,  C12N9/00 ,  C12N9/14 ,  C12N9/28 ,  C12N9/30 ,  C12N9/54 ,  C12N9/62 ,  C12P1/02 ,  C12P1/04 ,  C12P1/06 ,  C12P7/06 ,  C12P7/08

CPC classification number: C12P19/14 ,  C12P7/10 ,  Y02E50/16 ,  Y02E50/17

Abstract: The present invention relates to method of liquefying starch-containing material, wherein starch-containing material is subjected to a bacterial alpha-amylase at (a) a temperature around 50-80°C for 10-180 minutes, followed by (b) treatment at a higher temperature than used in step (a) for 1-60 minutes.

Abstract translation: 本发明涉及液化含淀粉材料的方法，其中含淀粉材料在（a）约50-80℃的温度下经受10-180分钟的细菌α-淀粉酶，接着（b）处理 在比步骤（a）中使用的时间更高的温度下进行1-60分钟。

公开(公告)号：WO02101051A3

公开(公告)日：2003-04-10

申请号：PCT/CA0200864

申请日：2002-06-11

Applicant: ECOPIA BIOSCIENCES INC ,  STAFFA ALFREDO ,  FARNET CHRIS M

Inventor： STAFFA ALFREDO ,  FARNET CHRIS M

IPC: C07K14/36 ,  C12N1/21 ,  C12N15/31 ,  C12N15/52 ,  C12N15/63 ,  C12P1/06

CPC classification number: C12N15/52 ,  C07K14/36

Abstract: Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from Streptomyces refuineus subsp. thermotolerans. The genes and proteins allow direct manipulation of benzodiazepines and related chemical structures via chemical engineering of the enzymes involved in the biosynthesis of anthramycin.

Abstract translation: 参与苯并二氮杂类生物合成的基因和蛋白质，包括从链霉菌（Streptomyces refuineus subsp。）中形成苯并二氮杂蒽环霉素生物合成基因座的基因和蛋白质。 thermotolerans。 基因和蛋白质可以通过化学工程来参与蒽环霉素的生物合成来直接操作苯并二氮杂类和相关的化学结构。

公开(公告)号：WO0176612A8

公开(公告)日：2002-06-20

申请号：PCT/US0111699

申请日：2001-04-10

Applicant: VALENT BIOSCIENCES CORP ,  WARRIOR PREM ,  HEIMAN DANIEL F ,  REHBERGER LINDA A ,  JOHNSON RONALD E ,  HANSEN JAMES R ,  MCVICKER KEVIN A

Inventor： WARRIOR PREM ,  HEIMAN DANIEL F ,  REHBERGER LINDA A ,  JOHNSON RONALD E ,  HANSEN JAMES R ,  MCVICKER KEVIN A

IPC: C12P1/02 ,  A01N61/00 ,  A01N63/00 ,  A01N63/02 ,  A61K35/66 ,  A61K35/74 ,  A61K36/06 ,  A61K36/062 ,  C12N1/20 ,  C12P1/00 ,  C12P1/04 ,  C12P1/06 ,  A61K35/84

CPC classification number: A61K35/74 ,  A01N63/02 ,  A61K35/742 ,  A61K36/06 ,  A61K36/062 ,  C12P1/02 ,  C12P1/04

Abstract: The present invention is directed to a method for producing a new nematocidal composition particularly useful against plant parasitic nematodes and also a process to prevent damage resulting from nematode infestation. The method for production of the composition involves heating a pH-adjusted fermentation broth of microorganisms to a temperature of at least about 100 DEG C for at least about 15 minutes. Preferably, the microorganism is Gibberella fujikuroi, Streptomyces erythraeus, Bacillus sphaericus, Bacillus thuringiensis or Fusarium moniliforme .

Abstract translation: 本发明涉及一种用于生产特别适用于植物寄生线虫的新型杀线虫组合物的方法，还涉及一种防止线虫侵袭引起的损害的方法。 制备组合物的方法包括将pH调节的微生物发酵液加热到至少约100℃的温度至少约15分钟。 优选地，微生物是赤霉病，红链霉菌，球形芽孢杆菌，苏云金芽孢杆菌或镰孢镰刀菌。

公开(公告)号：WO00058482A2

公开(公告)日：2000-10-05

申请号：PCT/US2000/007771

申请日：2000-03-23

IPC: C12N15/09 ,  C12N1/21 ,  C12N7/00 ,  C12N15/76 ,  C12P1/06 ,  C12R1/465 ,  C12R1/92

CPC classification number: C12R1/465 ,  C12N15/76 ,  C12R1/91

Abstract: The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient microbe, and producing a secondary metabolite from a microbe. The transducing phages typically have a broad host range, and transduce microbes in the Order Actinomycetales, in particular in the Family Streptomycetaceae, including Streptomyces coelicolor, Streptomyces lividans, Streptomyces venezuelae, Streptomyces avermitilis, and Saccharopolyspora erythraea. The transducing phages can be specialized transducing phages or generalized transducing phages.

Abstract translation: 本发明涉及分离的转导噬菌体，分离转导噬菌体的方法，以及使用转导性噬菌体的方法，包括例如将至少一种核酸片段从供体微生物转移至受体微生物，以及从 微生物。 转导噬菌体通常具有广泛的宿主范围，并且在放线菌纲中转导微生物，特别是在家族链霉菌科，包括天蓝色链霉菌（Streptomyces coelicolor），变形链霉菌（Streptomyces lividans），维生素链霉菌（Streptomyces venezuelae），阿维链霉菌（Streptomyces avermitilis）和糖酵母（Saccharopolyspora erythraea）中。 转导噬菌体可以是专门的转化噬菌体或广泛转导的噬菌体。

公开(公告)号：WO99055895A1

公开(公告)日：1999-11-04

申请号：PCT/EP1999/002670

申请日：1999-04-21

IPC: C12P1/06 ,  C12P15/00 ,  C12P7/00 ,  C12N1/20 ,  A61K31/00 ,  C12R1/04

CPC classification number: C12P15/00 ,  C12P1/06 ,  C12R1/04

Abstract: The present invention relates to a novel glucose-6-phosphate translocase inhibitor L 970871, which is produced by an Actinomycete sp. (culture number HIL-007997) during fermentation, a process for its preparation, to chemical derivatives derived from compound L 970871, to the use of compound L 970871 and derivatives derived therefrom and pharmacological active substances, as medicament and, in particular, for the treatment of diabetes mellitus, and to an Actinomycete sp. HIL-007997(DSM 11993) for producing the abovementioned compound L 970871.

Abstract translation: 本发明涉及一种新型的葡萄糖-6-磷酸转位酶抑制剂L 970871，其由放线菌属（Proinomycete sp。 （培养物编号HIL-007997），其制备方法，衍生自化合物L 970871的化学衍生物，使用化合物L 970871及其衍生物及其药理活性物质作为药物，特别是用于 治疗糖尿病，以及放线菌属（Actinomycete sp。 HIL-007997（DSM 11993），用于制备上述化合物L 970871。

公开(公告)号：WO8807580A3

公开(公告)日：1988-11-17

申请号：PCT/DE8800212

申请日：1988-03-31

Applicant: SOCOP NAHRUNGSMITTEL ,  WANK ANNA

Inventor： WANK ANNA

IPC: A01N63/00 ,  A01N63/02 ,  A01N63/04 ,  A23C9/127 ,  A23C9/13 ,  A23K10/18 ,  A61K8/99 ,  A61K36/06 ,  A61K36/062 ,  A61K36/48 ,  A61P17/00 ,  A61Q19/00 ,  C05F11/08 ,  C12N1/16 ,  C12N9/58 ,  C12P1/00 ,  C12P1/06 ,  A23K1/00

CPC classification number: C12N9/58 ,  A01N63/00 ,  A01N63/04 ,  A23C9/127 ,  A23C9/1322 ,  A23K10/18 ,  A61K8/99 ,  A61K36/06 ,  A61K36/062 ,  A61K36/48 ,  A61K2800/782 ,  A61K2800/85 ,  A61Q19/00 ,  A61K2300/00

Abstract: A biophysically derived yeast preparation is proposed which stimulates respiration in liver homogenate, contains an L-amino acid oxidase inhibiting factor, and exhibits excellent cicatrization properties and RES-stimulating action. The process for manufacturing the yield preparation consists in treating an initial yeast, if necessary with addition of a liquid support, until a light resuspended material is obtained, followed by a brief thermal shock treatment until gases are evolved by fermentation. In addition, fodder and plant hormone solutions containing these biophysically derived yeasts are proposed.

公开(公告)号：WO2020072908A1

公开(公告)日：2020-04-09

申请号：PCT/US2019/054703

申请日：2019-10-04

Applicant: MANUS BIO, INC.

Inventor： LOVE, Aaron ,  GHADERI, Adel ,  DONALD, Jason, Eric ,  SANTOS, Christine, Nicole, S. ,  KUMARAN, Ajikumar, Parayil

IPC: C12N1/20 ,  C12N1/26 ,  C12P1/04 ,  C12P1/06 ,  C12P7/00 ,  C12P19/00 ,  C12P23/00 ,  C12P33/00

Abstract: Aspects of the invention provide methods for producing one or more secondary metabolites from microbial culture. In various embodiments, the method comprises culturing a microbial cell producing a secondary metabolite for recovery from a bioreactor medium, the medium comprising an aqueous phase and an extraction phase. The composition of the extraction phase, and the relevant amount with respect to the aqueous phase, enhances production of the secondary metabolite from microbial cells and/or enhances extracellular transfer of the metabolite.