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    OLIGONUCLEOTIDE ASSEMBLY USING pH BASED ELECTRODE CONTROLLED HYBRIDIZATION
    3.
    发明申请
    OLIGONUCLEOTIDE ASSEMBLY USING pH BASED ELECTRODE CONTROLLED HYBRIDIZATION 审中-公开

    公开(公告)号：WO2022256143A1

    公开(公告)日：2022-12-08

    申请号：PCT/US2022/028408

    申请日：2022-05-10

    Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC

    Inventor： CHEN, Yuan-Jyue ,  NGUYEN, Bichlien Hoang ,  STRAUSS, Karin ,  SMITH, Jake Allen

    IPC: C12Q1/6806 ,  C12Q1/6823 ,  C12Q1/6834 ,  G16B50/00

    Abstract: Electrode controlled hybridization is used to change local pH and selectively assemble oligonucleotide complexes on the surface of a microelectrode array. The oligonucleotide complexes have sticky ends that provide locations for subsequent oligonucleotide complexes to hybridize. The order in which specific oligonucleotide complexes are joined together encodes information. Controlled activation of individual electrodes in the microelectrode array creates negative voltages that reduces a buffer solution and raises the pH in proximity to the electrodes. At higher pH levels double-stranded oligonucleotides de-hybridize. Nicks between oligonucleotide complexes and oligonucleotides anchored to the microelectrode array are closed creating covalent attachments. De-hybridized single-stranded oligonucleotides are removed leaving only the oligonucleotides connected to microelectrode array. Thus, during a given round of synthesis, oligonucleotide complexes are added only to the locations on the microelectrode array where the electrodes are not activated.

    MULTI-PLEX ASSAY PLATES AND METHODS OF MAKING
    4.
    发明申请
    MULTI-PLEX ASSAY PLATES AND METHODS OF MAKING 审中-公开

    公开(公告)号：WO2022232027A1

    公开(公告)日：2022-11-03

    申请号：PCT/US2022/026147

    申请日：2022-04-25

    Applicant: MESO SCALE TECHNOLOGIES, LLC.

    Inventor： KENTEN, John H. ,  NIKOLENKO, Galina

    IPC: G01N33/50 ,  C12Q1/6834 ,  G01N33/573

    Abstract: Described herein is a method of preparing a bifunctional assay surface. In particular, a method is provided for preparing an assay surface that includes a primary reagent and a secondary reagent. In one aspect, the primary and secondary reagents are immobilized on the assay surface by different surface chemistries. In one aspect, a method is provided for preparing an assay surface that includes a proteinaceous primary reagent and a thiol-containing secondary reagent. In one aspect, a method is provided for preparing an assay surface that includes a capture-target hybrid and a thiol-containing secondary reagent.

    STRUCTURE AND METHODS FOR DETECTION OF SAMPLE ANALYTES
    10.
    发明申请
    STRUCTURE AND METHODS FOR DETECTION OF SAMPLE ANALYTES 审中-公开

    公开(公告)号：WO2022060728A1

    公开(公告)日：2022-03-24

    申请号：PCT/US2021/050262

    申请日：2021-09-14

    Applicant: PALAMEDRIX, INC.

    Inventor： GOPINATH, Ashwin ,  ROTHEMUND, Paul ,  SHETTY, Rishabh ,  BOWEN, Shane

    IPC: B82Y5/00 ,  B82Y40/00 ,  C12Q1/6834 ,  G01N33/487 ,  G01N33/543

    Abstract: Provided herein are structures and methods for detecting one or more analyte molecules present in a sample. In some embodiments, the one or more analyte molecules are detected using one or more supramolecular structures. In some embodiments, the one or more supramolecular structures are specifically designed to minimize cross-reactivity with each other. In some embodiments, the supramolecular structures are bi-stable, wherein the supramolecular structures shift from an unstable state to a stable state through interaction with one or more analyte molecules from the sample. In some embodiments, the stable state supramolecular structures are configured to provide a signal for analyte molecule detection and quantification. In some embodiments, the signal correlates to a DNA signal, such that detection and quantification of an analyte molecule comprises converting the presence of the analyte molecule into a DNA signal.

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