公开(公告)号：WO2023278882A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/036035

申请日：2022-07-01

Applicant: BREWER SCIENCE, INC.

Inventor： FURY, Jonathan J. ,  CAO, Xi ,  LANDORF, Christopher ,  CHEN, Zun ,  NEESON, Alec ,  BOWEN, Weston ,  PETERS, Austin

IPC: G01N27/414 ,  G01N27/30 ,  G01N27/333 ,  G01N33/18 ,  G01N27/02 ,  G01N27/4146 ,  G01N27/4148

Abstract: A carbon nanotube (CNT) ion-selective field effect transistor (IS-FET) integrated device is used to detect nitrate ion in water. The device is operated as an IS-FET sensor, holding the measured potential between the drain electrode and an external reference electrode constant with a potentiometric circuit. Transduction occurs by changes in the effective CNT film gate potential with changes in the phase boundary potential of an ion-selective membrane (ISM) film. Moreover, the nitrate ISM film makes the device highly selective towards nitrate sensing. This printable IS- FET nitrate sensor enables real-time and high-resolution measurements and recording of nitrate ion in water at low cost.

公开(公告)号：WO2021222910A2

公开(公告)日：2021-11-04

申请号：PCT/US2021/036044

申请日：2021-06-04

Applicant: POSTREL, Richard

Inventor： POSTREL, Richard

IPC: F24F110/66 ,  G01N27/04 ,  G01N33/00 ,  B82Y15/00 ,  B82Y30/00 ,  G01N2035/00306 ,  G01N2035/00346 ,  G01N27/3278 ,  G01N27/4146 ,  G01N33/0047 ,  G01N33/487 ,  G01N33/497 ,  G01N35/00594

Abstract: The present invention provides a process and method for the early detection and diagnosis of disease by reading and decoding volatile organic compounds (VOCs) for signatures associated with a specific disease. From its outset, each disease begins producing its own unique set of volatile organic compounds. For many diseases, this early-stage detection may be many months or years before noticeable symptoms. The VOC emissions when analyzed, result in a "signature" that identifies and distinguishes the developing, or at later stages, the developed disease. The device assays non-invasively obtained biosamples in real-time to output a VOC based signature that, when correlated with data in a disease signature library, identifies one or more diseases associated with the sample.

公开(公告)号：WO2022221033A2

公开(公告)日：2022-10-20

申请号：PCT/US2022/022073

申请日：2022-05-19

Applicant: POSTREL, Richard

Inventor： POSTREL, Richard

IPC: C08K3/04 ,  G01N27/12 ,  G01N27/41 ,  G01N33/497 ,  G01N33/00 ,  B01L2300/0636 ,  B01L2300/18 ,  B01L2300/1805 ,  B01L3/502715 ,  B01L3/502761 ,  B01L7/00 ,  G01N27/02 ,  G01N27/4146 ,  G01N33/5438

Abstract: The present inven on provides a system and method for building and op mizing biose create a mulayered bio-sensing system by incorpora ng two different formats comprise single wall carbon tubular sensing element and ii) a non-tubular graphene sensing eler mul -layered system allows for assaying molecules across a large range of molecular w sensing molecules in both gas and liquid from a common sample simultanegiffiliyl. By co analyzing both larger, heavier molecules, including, but not limited to: proteins hormon acids, lipids, lipoproteins, etc., with non-tubular graphene sensors and smaller, lighter organic compounds (VOCs) as emi'ed in gas form from the same sample are assayed w walled-carbon nanotubules (SWNTs), this inven on provides a more complete, holis understanding of the organism's current state of health.

公开(公告)号：WO2019236974A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/036006

申请日：2019-06-07

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SHULAKER, Max ,  BISHOP, Mindy, Deanna

Inventor： SHULAKER, Max ,  BISHOP, Mindy, Deanna

IPC: G01N27/414 ,  G01N27/4141 ,  G01N27/4146

Abstract: A monolithic, three-dimensional (3D) integrated circuit (IC) device includes a sensing layer, a memory layer, and a processing layer. The sensing layer includes a plurality of carbon nanotube field-effect transistors (CNFETs) that are functionalized with at least 50 functional materials to generate data in response to exposure to a gas. The memory layer stores the data generated by the plurality of CNFETs, and the processing layer identifies one or more components of the gas based on the data generated by the plurality of CNFETs.

公开(公告)号：WO2023034113A2

公开(公告)日：2023-03-09

申请号：PCT/US2022/041497

申请日：2022-08-25

Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI

Inventor： WU, Chenglin ,  HUANG, Yue-Wern ,  KIM, DongHyun ,  WANG, Yang ,  LI, Yanxiao ,  WANG, Risheng ,  LI, Jiaoli ,  ZHANG, Yuwei

IPC: G01N27/414 ,  G01N33/569 ,  G01N33/53 ,  G01N33/50 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/56983

Abstract: A sensor for detecting virus, including virus particles and/or genetic sequences, and method of fabrication. The sensor includes a field effect transistor (FET) having source and drain electrodes formed on a substrate and a two-dimensional virus sensing transduction material (VSTM) film formed on the FET. The VSTM film is configured to collect a sample collected from a subject and comprises MXene-graphene. The VSTM film has an antibody corresponding to the virus particles to be detected linked to the film. A drain-source current response of the FET is representative of an amount of the virus particles in the sample for indicating an infection.

公开(公告)号：WO2022005780A1

公开(公告)日：2022-01-06

申请号：PCT/US2021/038125

申请日：2021-06-18

Applicant: ILLUMINA, INC.

Inventor： BOYANOV, Boyan ,  OTTO, Rico ,  MANDELL, Jeffrey G.

IPC: G01N27/414 ,  G01N33/487 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/48721

Abstract: Devices and methods of using the devices are disclosed which can provide scalability, improved sensitivity and reduced noise for sequencing polynucleotide. Examples of the devices include a biological or solid-state nanopore, a field effect transistor (FET) sensor with improved gate controllability over the channel, and a porous structure.

公开(公告)号：WO2020146823A1

公开(公告)日：2020-07-16

申请号：PCT/US2020/013218

申请日：2020-01-10

Applicant: ROSWELL BIOTECHNOLOGIES INC.

Inventor： MERRIMAN, Barry ,  GEISER, Tim ,  ALAGARSWAMY GOVINDARAJ, Venkatesh

IPC: G01N27/327 ,  H01L51/00 ,  G01N27/26 ,  G01N27/414 ,  C12Q1/68 ,  H01L21/764 ,  H01L29/06 ,  C07K14/001 ,  C07K2319/43 ,  C07K2319/50 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/6869 ,  G01N27/3278 ,  G01N27/4145 ,  G01N27/4146 ,  H01L51/0093 ,  H01L51/0098

Abstract: In various embodiments, a synthetic peptide finding use as a molecular wire in a molecular electronic circuit comprises an alpha helical segment further comprising repeating alpha-helical motifs. The synthetic peptide may further comprise at least one specific conjugation site between the termini for attachment to a 5 molecule such as a binding probe, and may further comprise termini having metal binding functionality such as repeats of material binding sequences. In various aspects, the synthetic peptide comprises intramolecular hydrogen bonding, salt bridges, and optionally, aromatic rings that provide for electrical conductivity through the peptide.

公开(公告)号：WO2018207220A1

公开(公告)日：2018-11-15

申请号：PCT/IT2018/050069

申请日：2018-04-23

Applicant: ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA

Inventor： SCAVETTA, Erika ,  FRABONI, Beatrice ,  GUALANDI, Isacco

IPC: G01N27/414 ,  G01N27/4146

Abstract: The present invention relates to an organic electrochemical transistor based on conducting polymers (for example PEDOT: PSS) in which the gate electrode has been integrated on the surface of the channel through the deposition of Ag halide nanoparticles, AgX (X = CI, Br, I). This configuration allows the device to operate without applying a potential difference to the gate electrode (with consequent reduction in operating costs). The device is able to detect the halide ion: by varying the nature of the nanoparticles and in particular by using AgX (X = CI, Br, I) or Ag2S the sensor acquires sensitivity towards anion X or sulfide.