公开(公告)号：WO2023048097A1

公开(公告)日：2023-03-30

申请号：PCT/JP2022/034822

申请日：2022-09-16

Applicant: 株式会社アイシン

Inventor： 重森　康司 ,  井上　慎介 ,  平野　明良 ,  田端　友紀

IPC: A61Q19/00 ,  B82Y5/00 ,  B82Y40/00 ,  A61K9/127 ,  B01J13/04 ,  A61K8/14

Abstract: 粒径が５０ナノメートル以下の微細水は、皮膚の角層内に入ると、皮膚を柔軟化して角層の隙間を拡張させることが知られている。このため、香粧品や皮膚外用薬などに適用した場合に、微細水を含有させた脂質膜小胞体が角層内に入るのを容易にすることができる。

公开(公告)号：WO2022181744A1

公开(公告)日：2022-09-01

申请号：PCT/JP2022/007783

申请日：2022-02-25

Applicant: 株式会社コーセー

Inventor： 池田　裕政

IPC: A61Q19/08 ,  A61K8/14 ,  A61K8/19 ,  A61K8/34 ,  A61K8/36 ,  A61K8/55 ,  A61K8/63 ,  A61K8/64 ,  A61K8/68 ,  B01J13/04

Abstract: 【課題】セラミド類及びステロール類の結晶析出を抑制し、広い温度領域での優れた経時安定性（セラミド類及びフィトステロールの結晶抑制効果、リポソーム組成物の安定性）及び水分閉塞性による保湿効果が得られ、さらにはツヤ感及びハリ感にも優れるリポソーム組成物を提供すること。 【解決手段】次の成分（Ａ）～（Ｄ）； （Ａ）リン脂質 （Ｂ）フィトステロール （Ｃ）セラミド類 （Ｄ）成分（ｄ１）ＩＯＢ値が１．８～３．５の多価アルコールから選ばれる１種又は２種以上及び／又は成分（ｄ２）ＩＯＢ値が４．５～５．５の多価アルコールから選ばれる１種又は２種以上 を含有し、前記成分（Ｄ）の各々が示すＩＯＢ値を含有質量比率に基づいて加重平均して求めた値が２．０を超え５．０未満である、リポソーム組成物。

公开(公告)号：WO2022087425A1

公开(公告)日：2022-04-28

申请号：PCT/US2021/056270

申请日：2021-10-22

Applicant: JOHNSON, Lanny Leo

Inventor： JOHNSON, Lanny Leo

IPC: A01N37/40 ,  A01N31/02 ,  A01N35/04 ,  A01N43/16 ,  A23B7/154 ,  A23L3/3508 ,  A61K8/14 ,  A61K9/08 ,  A61K9/127

Abstract: A suture or a surgical or wound closure staple is disclosed that includes protocatechuic acid. The protocatechuic acid may be coated on, or impregnated in, the suture or wound closure staple. The suture or wound closure staple may include polypropylene, nylon, polyester, and/or braided polyester, catgut, 85/15 D,L lactide/glycolide, and/or 910 Vicryl. The protocatechuic acid may coat 25% or more of the surface of the suture or surgical staple. In embodiments, the protocatechuic acid may have a purity of 95% or greater. The protocatechuic acid may include crystalline protocatechuic acid.

公开(公告)号：WO2021244597A1

公开(公告)日：2021-12-09

申请号：PCT/CN2021/098057

申请日：2021-06-03

Applicant: 江南大学

Inventor： 夏咏梅 ,  柳欢 ,  孟新宇 ,  方云 ,  樊晔 ,  沈洁 ,  刘湘

IPC: A61K9/127 ,  A61K47/12 ,  A61K47/20 ,  A61K31/375 ,  A61P3/02 ,  A61K8/67 ,  A61K8/36 ,  A61K8/14 ,  A61Q19/00 ,  A23L33/15 ,  A23L33/12 ,  A23L29/00 ,  A23L29/04 ,  A23L29/055 ,  A23V2002/00 ,  A61K8/361 ,  A61K8/676 ,  A61K9/1271

Abstract: 一种脂肪酸基VC脂质体的制备方法，以工业共轭亚油酸和其它脂肪酸以及十二烷基硫酸钠的复合物为囊材，囊材在酸性条件(pH＜7)下于水相自组装包埋维生素C形成脂肪酸基维生素C脂质体。所述制备方法不会用到有机溶剂等对人体有害的物质，具有安全、健康的特性，制备得到的脂肪酸脂质体除了能够在酸性条件下包封VC，同时还能对VC起到缓释的作用。

公开(公告)号：WO2021240163A1

公开(公告)日：2021-12-02

申请号：PCT/GB2021/051295

申请日：2021-05-27

Applicant: CHOPRA, Sunil

Inventor： CHOPRA, Sunil

IPC: A61K38/14 ,  A61K8/06 ,  A61K8/11 ,  A61K8/14 ,  A61P17/14 ,  A61Q5/06 ,  A61Q7/00

Abstract: The present disclosure relates to bleomycin for use in the treatment and/or prevention of hair loss and to a composition comprising bleomycin for use in the treatment and/or prevention of hair loss. A non- therapeutic method for promoting hair generation and/or hair growth is also disclosed, the method comprising administering or applying bleomycin or a composition comprising bleomycin to an area on the subject where the promotion of hair generation and/or hair growth is desired. Further disclosed is a non-therapeutic method for darkening hair, the method comprising administering or applying bleomycin or a composition comprising bleomycin to an area on the subject where darkening of hair is desired.

公开(公告)号：WO2021234536A1

公开(公告)日：2021-11-25

申请号：PCT/IB2021/054209

申请日：2021-05-17

Applicant: OFFHEALTH S.P.A.

Inventor： ZANINI, Alessandro ,  VELLANTE, Marco ,  SODO, Eugenio ,  CAVALLO, Giovanni ,  FOSCHINI, Fulvio ,  GIUVA, Roberto

IPC: A61K8/04 ,  A61K8/14 ,  A61K8/55 ,  A61K8/67 ,  A61K8/92 ,  A61K8/34 ,  A61P17/00 ,  A61Q19/00 ,  A61Q1/14 ,  A61K8/03

Abstract: A lipophilic composition for an eye contour gel, with a soothing and cleansing action on the eyelid waterline and the periocular area indicated for the treatment of blepharitis or similar diseases, comprises: liposomes with a particle size less than one micron, or even less than 200 nm, consisting of non-hydrogenated phospholipids which carry Vitamin A Palmitate, Bisabolol, Tea Tree oil and Vitamin E TPGS, Xanthan gum as a viscosifying, gelling and structuring agent with good wetting capacity, and Ferulic acid which, specifically intercalated in the liposomes, protects Vitamin A Palmitate from degradation. By adding Vitamin E TPGS in the liposome preparation step, Vitamin E is inserted into the phospholipid multilayer, while the hydrophilic part thereof, PEG, remains outside the liposomes. This allows the liposomal structure to increase the ability to coordinate water, since the liposomes with PEG chains outside the structure thereof act as "traps" (WHC, Water Holding Capacity) or as "binders" (WBC, Water Binding Capacity).

公开(公告)号：WO2021207630A1

公开(公告)日：2021-10-14

申请号：PCT/US2021/026624

申请日：2021-04-09

Applicant: NORTHWESTERN UNIVERSITY

Inventor： MIRKIN, Chad, A. ,  CALLMANN, Cassandra, Elizabeth

IPC: A61K8/14 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713

Abstract: The disclosure is generally related to nanoparticles have an oxidized tumor cell lysate encapsulated therein and oligonucleotides on the surface thereof. Methods of making and using the nanoparticles are also provided herein.

公开(公告)号：WO2021202493A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/024836

申请日：2021-03-30

Applicant: L'OREAL ,  LE CLAIRE, Laurianne ,  WANG, Miao ,  COTTARD, Jerome

Inventor： LE CLAIRE, Laurianne ,  WANG, Miao ,  COTTARD, Jerome

IPC: A61K8/14 ,  A61K8/34 ,  A61K8/35 ,  A61K8/42 ,  A61K8/68 ,  A61K8/85 ,  A61K8/90 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/08 ,  A61K8/342 ,  A61Q19/004 ,  A61Q19/007

Abstract: The ceramide composition includes capsules dispersed in the ceramide composition, the capsules comprising a shell and a core. The shell includes a polycaprolactone, a block copolymer, and a surfactant. The core includes ceramide NP, hydroxypalmitoyl sphinganine, 2-oleamido-1,3-octadecanediol, and a hydrophobic solvent. The core has a weight ratio of the ceramide NP of (i) and the hydroxypalmitoyl sphinganine of (ii) to the 2-oleamido-1,3-octadecanediol of (iii) is from 1:2.5 to 1:5. Additionally, the ceramide composition includes hydroxyacetophenone and hydrophilic solvent.

公开(公告)号：WO2021005104A1

公开(公告)日：2021-01-14

申请号：PCT/EP2020/069239

申请日：2020-07-08

Applicant: BASF SE

Inventor： LEE, Dong Ryeol ,  LIU, Zhao Ting ,  ZHANG, Yang

IPC: A61K8/02 ,  A61K8/14 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/44 ,  A61K8/45 ,  A61K8/46 ,  A61Q5/02 ,  A61Q5/12

Abstract: The presently claimed invention relates to liquid crystal lipid particles. The presently claimed invention relates to liquid crystal lipid particles which are used in hair care composition and exhibit excellent hair moisturizing effect.

公开(公告)号：WO2020124183A1

公开(公告)日：2020-06-25

申请号：PCT/BR2019/050541

申请日：2019-12-17

Applicant: DE OLIVEIRA LIMA FILHO, Moacir

Inventor： DE OLIVEIRA LIMA FILHO, Moacir

IPC: A61K36/31 ,  A61K8/9789 ,  A61K8/06 ,  A61K8/14 ,  A61K9/107 ,  A61K9/127 ,  A61K9/51 ,  A61K127/00 ,  A61P17/00 ,  A61P17/02

Abstract: A presente invenção refere-se a composições farmacêuticas ou cosméticas compreendendo extrato de Brassica oleracea, preferencialmente Brassica oleracea var capitata, em sistemas nanoestruturados, tais como lipossomas, nanopartículas lipídicas sólidas, nanoemulsões, nanotubos, nanocápsulas, nanosferas, microemulsões ou outros sistemas de carreamento de fármacos com tamanho médio inferior a 1 gm e superior a 20 nm. Os sistemas nanoestruturados de acordo com a presente invenção compreendem fosfolipídos(s) natural(is) ou sintético(s) e/ou surfactante(s) e/ou colesterol e/ou óleos vegetais, tais como rícino, algodão, amêndoas, uva, dentre outros. Tais sistemas permitem aumento da biodisponibilidade dos ativos, com potencialização da ação e redução da toxicidade.