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公开(公告)号：WO2023091455A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050057
申请日：2022-11-16
Applicant: GENERAL PROGNOSTICS INC.
Inventor： DEPA, Michal , CHUGH, Soumil , JENA, Sidhant , ECHENIQUE, Javier, J. , MATSUOKA, Shunsuke , TRIBBLE, Theresa
Abstract: Methods, systems, and computer readable storage medium storing processor executable instructions for evaluating the quality of a sample card comprising a biological sample. A method of evaluating the quality of a sample card comprising a biological sample and/or an image of the sample card: determining a location of a serum zone in the sample card at least in part by analyzing the image of the sample card using at least one image processing technique; determining at least one characteristic of the serum zone based on the identified location of the serum zone; and determining a measure of quality of the sample card and/or the image of the sample card based on the at least one characteristic of the serum zone.
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公开(公告)号：WO2023090925A1
公开(公告)日：2023-05-25
申请号：PCT/KR2022/018265
申请日：2022-11-18
Applicant: 주식회사 씨젠
Abstract: 본 개시는 자동화 분자진단 시스템을 이용한 고처리량(High throughput) 등온 증폭 방법에 관한 것이다. 본 개시에 따른 방법은 짧은 시간 내에 대량의 샘플로부터 타겟 핵산을 신속하게 검출할 수 있으므로, 대량의 샘플의 분자진단이 필요한 대형 병원, 수탁 검사 기관, 연구소 등에서 유용하게 적용될 수 있다.
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公开(公告)号：WO2023087964A1
公开(公告)日：2023-05-25
申请号：PCT/CN2022/123905
申请日：2022-10-08
Applicant: 江苏液滴逻辑生物技术有限公司
IPC: B01L3/00
Abstract: 本公开提供了一种微流控芯片、及其注液方法和用途。所述微流控芯片包括由下至上依次叠置的微流控芯片基板、导电盖子和注液壳体。所述注液壳体上设置有至少一个注液导管和进油导管。所述注液壳体包括注油腔、样本定量腔和并列设置的至少一个注液腔，所述注油腔、样本定量腔和至少一个注液腔分别用于设置油泡罩、样本定量塞和至少一个试剂泡罩。所述至少一个注液腔内分别设置有连接所述至少一个注液导管中对应的注液导管的注液柱，所述至少一个注液导管中的每个注液导管形成一注液通道。所述注油腔内设置有注油柱，所述注油柱连接所述进油导管。所述注油腔和所述至少一个注液腔的表面均对应设置有尖刺部件。
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公开(公告)号：WO2023087280A1
公开(公告)日：2023-05-25
申请号：PCT/CN2021/131916
申请日：2021-11-19
Applicant: 深圳华大生命科学研究院
Abstract: 一种微流控装置，包括旋转机构（1）、旋转组件（2）和微流控组件（3），所述旋转组件（2）与所述微流控组件（3）通过所述旋转机构（1）转动连接；所述旋转组件（2）包括第一限位机构（22）、旋转组件本体（23）和密封层（24），所述密封层（24）下表面设置有用于流体通过的微流道槽（71，72，73，74）；所述微流控组件（3）包括盖板（31）和流道板（32），所述盖板（31）上设有流道口（41，42，43，44）和过液孔对（61，62，63，64），所述流道板（32）上设有多个流道段，过液孔对（61，62，63，64）可与所述密封层（24）上的微流道槽（71，72，73，74）配合，使得相应流道段连通。
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公开(公告)号：WO2023084246A1
公开(公告)日：2023-05-19
申请号：PCT/GB2022/052886
申请日：2022-11-14
Applicant: OXFORD NANOPORE TECHNOLOGIES PLC
Inventor： UPSDELL, Jonathan
IPC: B01L3/00
Abstract: A fluidic device, such as an electrowetting-on-dielectric device, is provided. The device comprises a fluid chamber containing apolar fluid. The fluid chamber comprises an input port and a channel fluidly connected to the input port. The input port is formed with an opening to receive a pipette tip and impart a droplet of polar fluid into the channel. The insertion of the pipette tip into the fluid chamber causes displacement of the apolar fluid in the fluid chamber such that when the pipette tip is retracted from the fluid chamber, apolar fluid displaces the polar fluid from the surface of the pipette tip to form a droplet of polar fluid surrounded by apolar fluid in the channel of the fluid chamber.
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Patent Agency Ranking
公开(公告)号：WO2023083704A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/080770
申请日：2022-11-04
Applicant: ROBERT BOSCH GMBH
Inventor： SCHEUFELE, Bernd , BOTT, Hannah
Abstract: Es wird eine Mikrofluidische Vorrichtung (10) beschrieben, umfassend ein Rückhalteelement (7), insbesondere einen Mikrofilter und/oder ein Mikrosieb mit Poren, wobei die mikrofluidische Vorrichtung (10) zumindest vier mikrofluidische Kanäle (1, 2, 3, 4) mit je einem fluidischen Anschluss (1a, 2a, 3a, 4a) umfasst, wobei der erste mikrofluidische Kanal (1) und der zweite mikrofluidische Kanal (2) ein erstes Kanalsystem bilden, welches durch das Rückhalteelement (7) hindurchführt und wobei der dritte mikrofluidische Kanal (3) und der vierte mikrofluidische Kanal (4) ein, insbesondere fluidisch mit dem ersten Kanalsystem verbundenes, zweites Kanalsystem bilden, welches entlang einer ersten Seite (7a) des Rückhalteelements (7) führt.
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公开(公告)号：WO2023083425A1
公开(公告)日：2023-05-19
申请号：PCT/DK2022/050235
申请日：2022-11-09
Applicant: MOTILITYCOUNT APS
Inventor： LARSEN, Jacob Møllenbach , LAURSEN, Steen Broch
Abstract: The present invention relates to a mesoscale fluidic device for separating motile cells from non-motile cells, the mesoscale fluidic device comprising a substrate having a sample application compartment below a medium compartment, and a cell permeable filter with a pore size in the range of 1 µm to 20 µm, the cell permeable filter having an upper surface facing the medium compartment and a lower surface facing the sample application compartment, with the sample application compartment and the medium compartment being in fluid communication via the cell permeable filter, wherein the sample application compartment has a floor and at least one flow structure extending from the floor towards the lower surface of the cell permeable filter facing the sample application compartment. The device is especially useful for obtaining a medium enriched in motile sperm cells from a mammal sperm sample.
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公开(公告)号：WO2023081300A2
公开(公告)日：2023-05-11
申请号：PCT/US2022/048856
申请日：2022-11-03
Applicant: ABBOTT LABORATORIES , YOSHIMURA, Toru , ARAI, Yoshiyuki , KOMORI, Tomotaka , CHIBA, Ryotaro , HUFF, Jeffrey
Inventor： YOSHIMURA, Toru , ARAI, Yoshiyuki , KOMORI, Tomotaka , CHIBA, Ryotaro , HUFF, Jeffrey
IPC: B01L3/00
Abstract: Sample analysis systems and methods using assay surfaces, assay processing units (APUs), assay processing systems (APSs), and laboratory systems are disclosed. An assay surface includes a sample processing component comprising a plurality of regions, including at least one wash region and at least one storage region configured to hold a plurality of solid supports moveable through the regions under a magnetic force, and a detection component configured to receive the solid supports. An APU includes an assay surface receiving component, a magnetic element configured to generate a moveable magnetic field, and one or more processors configured to move the magnetic field. An APS includes one or more assay surfaces and an APU. A laboratory system includes one or more APSs and a controller for parallel processing. Sample processing and detection methods are disclosed with a reduced sample volume and/or shortened processing time and/or higher sensitivity.
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公开(公告)号：WO2023081272A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/048807
申请日：2022-11-03
Applicant: URO-1, INC.
Inventor： SNOKE, Phillip, Jack , COLLINS PRESNELL, Sharon , ALLRED, Philip, Morrison, III , BELLEZA, Ted
Abstract: A tissue core sample in a metal core collector or stylet is touched to a substrate channel filled with as special liquid such as a hydrogel to which the tissue core sample is attracted to thereby transfer the tissue sample to the channel while preserving the integrity of the sample, speeding up the transfer and preserving the sample orientation so it can be unambiguously associated with its anatomical origin.
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公开(公告)号：WO2023080305A1
公开(公告)日：2023-05-11
申请号：PCT/KR2021/016371
申请日：2021-11-10
Applicant: 주식회사 위즈바이오솔루션
Abstract: 본 발명은 일체형 분자 진단 장치 및 이를 이용한 분자 진단 방법에 관한 것으로, 시료를 채취하는 시료 채취 도구가 삽입되고, 채취된 시료로부터 추출된 핵산이 포함된 시료 용액을 생성하는 버퍼 튜브, 버퍼 튜브와 결합하여 시료 용액을 공급받고, 유체 채널을 통해 시료 용액을 반응 챔버로 이송하고, 일정 온도의 열을 공급받아 핵산 증폭 반응을 수행하는 카트리지, 및 카트리지와 탈착 가능하게 결합하여 반응 챔버에 상기 일정 온도의 열을 공급하고, 핵산 증폭 반응을 검출하여 진단 대상의 존재 여부를 진단하는 진단 모듈 본체를 포함한다.
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