The invention relates to a high-strength long-fatigue life wheel steel used for a heavy truck and a manufacturing method thereof, belonging to the technical field of high-strength stamping wheel steel for the heavy truck. The wheel steel comprises the following components: 0.12-0.14% of C, less than or equal to 0.05% of Si, 1.1-1.3% of Mn, 0.008-0.015% of P, less than or equal to 0.003% of S, 0.030-0.060% of Al, 0.015-0.025% of Nb, 0.01-0.02% of Ti, less than or equal to 23ppm of O, less than or equal to 33ppm of N and the balance of Fe and inevitable impurities. The manufacturing process comprises the following steps of: molten iron pretreatment to remove sulphur, top and bottom-blown converter smelting, LF (low frequency) furnace refining, slab casting, hot rolling to obtain the finished product. The wheel steel provided by the invention has the advantages that: compared with the traditional wheel steel, the tensile strength can reach more than 500MPa, the elongation percentage is more than 30%, the flexible life of a manufactured steel ring is more than 500000 times, the radial fatigue life is more than 1450000 times, and the weight of the wheel is reduced by 12-15%. The self weight of a car body is effectively reduced, and the oil consumption is reduced, thus the wheel steel is an ideal plate used for producing wheel rims and wheel arms of the heavy truck.