The invention relates to a process for removing non-metallic inclusions in molten steel. The process comprises the following steps of: placing the molten steel into a top-bottom combined blowing converter for performing smelting, then performing steel tapping, adding granular lime and fluorite in the steel tapping process, adding a sustained-release deoxidizing agent on the slag surface at the end of the steel tapping, and blowing argon from the bottom of a ladle for stirring after the end of the steel tapping; performing secondary refining on the molten steel; and sequentially performing primary soft blowing stirring, feeding of a silicon-calcium wire after reaching a wire feeding position and secondary soft blowing stirring on the molten steel after refining, and then performing the continuous casting step for full-protection casting. In the invention, the primary soft blowing is performed after the end of the secondary refining, thereby improving the Als/Alt ratio of the molten steel; and then the silicon-calcium wire is fed, and the secondary soft blowing is further performed for further improving the Als/Alt ratio, thereby being capable of effectively controlling the type B inclusions, being low in input of consumptive raw materials, being capable of realizing multi-converter continuous casting and the like.