The invention provides a coordination control device and method for a chassis integrated control system of a wheel driving electric vehicle and belongs to the field of electric vehicles. The device comprises a driver manipulation platform, an attitude parameter ideal value generating unit, a vehicle side-deviation observation unit, a yaw angular speed sensor, a vehicle speed sensor, a left front wheel speed sensor, a right front wheel speed sensor, a left rear wheel speed sensor, a right rear wheel speed sensor, a coordination control unit, an AFS controller, an ABS controller and a DYC controller. According to the device and method, different working conditions of vehicle driving are analyzed, the control working conditions suitable for all subsystems are judged, the coordination control system is designed, the responsibilities of the subsystems are allocated reasonably, the subsystems can give play to respective advantages, the vehicle stability is improved, the problem that the subsystems in a chassis integrated system are coupled to one another is solved, and functions of the subsystems are brought into play to the greatest extent.