The invention provides a manufacturing method for lowering ferrite-pearlite type segregation of cold rolled low-alloy high-strength steel and belongs to the technical field of iron and steel making and controlled rolling and cooling. The low-alloy high-strength steel comprises, by mass, 0.045%-0.075% of C, 0.85%-1.1% of Mn, 0.15%-0.25% of Si, 0.025%-0.055% of Alt, 0.03%-0.04% of Nb, not larger than 0.015% of limited element P, not larger than 0.012% of S, not larger than 0.006% of N and the balance Fe and inevitable impurities. The production technology comprises the steps of smelting, continuous casting, hot rolling, cold rolling and hot galvanizing. The finishing ductility is 0.9-1.6%, and the withdrawal straightening ductility is 0.2-0.4%. The manufacturing method for lowering the ferrite-pearlite type segregation of the cold rolled low-alloy high-strength steel has the advantages that through control over the contents of C, Si and Mn and technological control, the produced cold rolled low-alloy high-strength steel has excellent mechanical property, the ferrite-pearlite type segregation is also lowered, and the grade of a banded structure is 1.0 or lower.