发明公开
- 专利标题: CELLS PRODUCING ANTIBODY COMPOSITIONS
- 专利标题(中): 抗体组合物产生细胞
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申请号: EP01974718申请日: 2001-10-05
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公开(公告)号: EP1331266A4公开(公告)日: 2005-07-13
- 发明人: KANDA YUTAKA , SATOH MITSUO , NAKAMURA KAZUYASU , UCHIDA KAZUHISA , SHINKAWA TOYOHIDE , YAMANE NAOKO , HOSAKA EMI , YAMANO KAZUYA , YAMASAKI MOTOO , HANAI NOBUO
- 申请人: KYOWA HAKKO KOGYO KK
- 专利权人: KYOWA HAKKO KOGYO KK
- 当前专利权人: KYOWA HAKKO KOGYO KK
- 优先权: JP2000308526 2000-10-06
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/00 ; C07K16/06 ; C07K16/18 ; C07K16/28 ; C07K16/32 ; C12N5/10 ; C12N9/04 ; C12N9/10 ; C12N9/12 ; C12N9/88 ; C12N9/90 ; C12P21/00 ; C12P21/08 ; C12N15/10 ; A01K67/00 ; C12N9/00 ; C12N15/52 ; G01N33/53
摘要:
Cells to be used in producing antibody compositions, for example, an antibody having a high antibody-dependent cellular cytotoxic activity which is useful in various diseases, an antibody fragment or a fused protein having the Fc domain of the antibody; a process for producing an antibody composition by using these cells; antibody compositions; and uses thereof. In the above-described antibody compositions, the ratio of sugar chains, which are free from fucose bonded to N-acetylglucosamine at the sugar chain reducing end, to the total N-glycoside linkage complex sugar chains bonded to the Fc domain amounts to 20% or more. Moreover, novel GDP-mannose 4,6-dehydrogenase, GDP-keto-6-deoxymannose 3,5-epimerase 4-reductase, GDP-beta-L-fucose pyrophosphorylase, alpha-1,6-fucosyltransferase and DNAs encoding the same are provided.
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