公开(公告)号：EP1333032A4

公开(公告)日：2005-03-16

申请号：EP01974669

申请日：2001-10-03

申请人： KYOWA HAKKO KOGYO KK

发明人： SHINKAWA TOYOHIDE ,  UCHIDA KAZUHISA ,  YAMASAKI MOTOO ,  HOSAKA EMI ,  SHITARA KENYA

IPC分类号： C07K16/06 ,  C07K16/28 ,  C07K1/22 ,  A61K39/395 ,  A61K45/00 ,  G01N33/531

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K16/065 ,  C07K2317/24 ,  C07K2317/732

摘要： An antibody having desired properties which is purified by a method with the use of a substance having an affinity for a sugar chain binding to the antibody; drugs containing the antibody purified by the above method as the active ingredient; and a method of diagnosing or preventing various diseases by using a substance having an affinity for a sugar chain binding to the antibody.

公开(公告)号：EP1176195A4

公开(公告)日：2005-03-02

申请号：EP00915403

申请日：2000-04-07

申请人： KYOWA HAKKO KOGYO KK

发明人： HANAI NOBUO ,  NAKAMURA KAZUYASU ,  HOSOKA EMI ,  YAMASAKI MOTOO ,  UCHIDA KAZUHISA ,  SHINKAWA TOYOHIDE ,  IMABEPPU SUSUMU ,  KANDA YUTAKA ,  YAMANE NAOKO ,  ANAZAWA HIDEHARU

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  C12P21/08 ,  G01N33/53 ,  C12N15/09 ,  A61K39/00 ,  C12P21/00

CPC分类号： C07K16/3084 ,  A61K2039/505 ,  C07K16/2866 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2319/00 ,  C12P21/005 ,  G01N33/53

摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.

公开(公告)号：EP1469065A4

公开(公告)日：2006-05-10

申请号：EP02793391

申请日：2002-12-25

申请人： KYOWA HAKKO KOGYO KK

发明人： SHITARA KENYA ,  SAKURADA MIKIKO ,  UCHIDA KAZUHISA ,  SHINKAWA TOYOHIDE ,  SATOH MITSUO ,  NAKANO RYOSUKE

IPC分类号： A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  C12N5/10 ,  A01H5/00 ,  A01K67/027 ,  A61K39/395 ,  C12N15/00

CPC分类号： C07K16/2887 ,  A01K2217/05 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/72 ,  C07K2317/732

摘要： A composition comprising an antibody molecule which binds specifically to CD20 and has an N-glycoside bond complex type sugar chain Fc domain; cells or a transgenic nonhuman animal or plant producing the composition; a process for producing the antibody composition; and drugs containing the antibody composition.

公开(公告)号：EP1331266A4

公开(公告)日：2005-07-13

申请号：EP01974718

申请日：2001-10-05

申请人： KYOWA HAKKO KOGYO KK

发明人： KANDA YUTAKA ,  SATOH MITSUO ,  NAKAMURA KAZUYASU ,  UCHIDA KAZUHISA ,  SHINKAWA TOYOHIDE ,  YAMANE NAOKO ,  HOSAKA EMI ,  YAMANO KAZUYA ,  YAMASAKI MOTOO ,  HANAI NOBUO

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/06 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C12N5/10 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12P21/00 ,  C12P21/08 ,  C12N15/10 ,  A01K67/00 ,  C12N9/00 ,  C12N15/52 ,  G01N33/53

CPC分类号： C07K16/3084 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/065 ,  C07K16/18 ,  C07K16/2866 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/90 ,  C12P21/005

摘要： Cells to be used in producing antibody compositions, for example, an antibody having a high antibody-dependent cellular cytotoxic activity which is useful in various diseases, an antibody fragment or a fused protein having the Fc domain of the antibody; a process for producing an antibody composition by using these cells; antibody compositions; and uses thereof. In the above-described antibody compositions, the ratio of sugar chains, which are free from fucose bonded to N-acetylglucosamine at the sugar chain reducing end, to the total N-glycoside linkage complex sugar chains bonded to the Fc domain amounts to 20% or more. Moreover, novel GDP-mannose 4,6-dehydrogenase, GDP-keto-6-deoxymannose 3,5-epimerase 4-reductase, GDP-beta-L-fucose pyrophosphorylase, alpha-1,6-fucosyltransferase and DNAs encoding the same are provided.