公开(公告)号：EP1469065A4

公开(公告)日：2006-05-10

申请号：EP02793391

申请日：2002-12-25

申请人： KYOWA HAKKO KOGYO KK

发明人： SHITARA KENYA ,  SAKURADA MIKIKO ,  UCHIDA KAZUHISA ,  SHINKAWA TOYOHIDE ,  SATOH MITSUO ,  NAKANO RYOSUKE

IPC分类号： A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  C12N5/10 ,  A01H5/00 ,  A01K67/027 ,  A61K39/395 ,  C12N15/00

CPC分类号： C07K16/2887 ,  A01K2217/05 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/72 ,  C07K2317/732

摘要： A composition comprising an antibody molecule which binds specifically to CD20 and has an N-glycoside bond complex type sugar chain Fc domain; cells or a transgenic nonhuman animal or plant producing the composition; a process for producing the antibody composition; and drugs containing the antibody composition.

公开(公告)号：EP1295939A4

公开(公告)日：2005-02-02

申请号：EP01941064

申请日：2001-06-15

申请人： KYOWA HAKKO KOGYO KK

发明人： YAMANO KAZUYA ,  SEKINE SUSUMU ,  SATOH MITSUO ,  OTA TOSHIO ,  FURUYA AKIKO ,  SHIBATA KENJI ,  KOBAYASHI YUKI ,  TAKEBAYASHI MIHO ,  NAKAMURA YUSUKE ,  SUGANO SUMIO

IPC分类号： A61K38/00 ,  A61P1/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/14 ,  A61P5/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  C07K14/47 ,  C07K16/18 ,  C07K16/26 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  C12P21/08 ,  C12N15/00 ,  A61K38/17 ,  A61K48/00 ,  C12N5/00 ,  C12P21/02 ,  C12Q1/68

CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4743 ,  C07K16/18 ,  C07K2317/34

摘要： A protein, a DNA encoding this protein and an antibody recognizing this protein. Use of these substances makes it possible to provide a method of judging diseases relating to the novel insulin-like growth factor-binding protein, and diagnostics, preventives and remedies for diseases relating to the above-described protein.

公开(公告)号：EP1792987A4

公开(公告)日：2008-01-23

申请号：EP05768941

申请日：2005-08-05

申请人： KYOWA HAKKO KOGYO KK

发明人： NISHIYA HARUE ,  SATOH MITSUO ,  MORI KATSUHIRO

IPC分类号： C12N15/11 ,  A61K39/395 ,  C07K2/00 ,  C07K16/00 ,  C12N5/10 ,  C12P21/02 ,  C12P21/08

CPC分类号： C12P21/005 ,  C12N9/1051 ,  C12N9/88

摘要： It is intended to provide a cell having an RNA, which inhibits the function of an enzyme catalyzing the reaction of converting GDP-mannose into GDP-4-keto,6-deoxy-GDP mannose, transferred thereinto; a method of producing a glycoprotein composition by using this cell; a cell having an RNA which inhibits the function of an enzyme participating in the sugar chain modification of the binding, via a-bond, of the 1-position of fucose to the 6-position of N-acetylglucosamine at the reducing end of an N-glycoside bond type complex sugar chain, an RNA which inhibits the function of an enzyme protein participating in the intracellular synthesis of a sugar nucleotide GDP-fucose, or an RNA inhibiting the function of a protein participating in the intracellular transport of a sugar nucleotide GDP-fucose into the Golgi body, transferred thereinto; a method of producing a glycoprotein composition by using this cell; and so on.

公开(公告)号：EP1452594A4

公开(公告)日：2007-01-10

申请号：EP02781768

申请日：2002-11-14

申请人： KYOWA HAKKO KOGYO KK ,  SASAI YOSHIKI ,  IWATA HIROO

发明人： SASAI YOSHIKI ,  IWATA HIROO ,  MURAKAMI YOSHINOBU ,  SATOH MITSUO ,  KOBORI MASATO ,  YANO KEIICHI

IPC分类号： A61K35/12 ,  A61K35/48 ,  A61K38/17 ,  A61P17/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C12N5/071 ,  C12N5/073 ,  C12N15/12 ,  G01N33/50 ,  G01N33/68 ,  C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  C07K14/47 ,  C12N5/06 ,  C12Q1/02 ,  G01N33/15

CPC分类号： G01N33/5073 ,  A61K35/12 ,  A61K35/48 ,  A61K38/1709 ,  C12N5/0603 ,  C12N5/0619 ,  C12N2501/415 ,  C12N2501/90 ,  C12N2501/91 ,  C12N2502/13 ,  C12N2503/02 ,  C12N2506/02 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5058 ,  G01N33/6896

摘要： A method of obtaining a solution having an activity of inducing the differentiation of embryo stem cells into ectodermal cells or ectoderm-origin cells which involves the step of culturing stroma cells with the use of a liquid medium containing a polyanion compound and then recovering the liquid medium; a solution having an activity of inducing the differentiation of embryo stem cells into ectodermal cells or ectoderm-origin cells which is obtained by using the above method; and an inducer for the differentiation of embryo stem cells into ectodermal cells or ectoderm-origin cells.

公开(公告)号：EP1498485A4

公开(公告)日：2006-09-06

申请号：EP03720897

申请日：2003-04-09

申请人： KYOWA HAKKO KOGYO KK

发明人： OHNUKI NAOKO ,  SATOH MITSUO ,  MORI KATSUHIRO ,  YAMANO KAZUYA

IPC分类号： A61P9/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  C07K16/30 ,  C12N9/10 ,  C12P21/08 ,  C12N15/09 ,  A01H5/00 ,  A01K67/027 ,  A61K39/395 ,  C07K16/00 ,  C12N5/10

CPC分类号： C07K16/3084 ,  A01K2217/075 ,  C07K16/2866 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732 ,  C12N9/1051 ,  C12N2510/00 ,  C12Y204/01068

摘要： Cells wherein the genome has been modified so that the activity of an enzyme relating to the sugar chain modification of binding the 1-position of fucose to the 6-position of a N-acetylglucosamine at the reducing end of a complex N-glycoside linked sugar chain via an α-bond is lowered, compared with the activity in the parent strain cells, or deleted; and a process for producing an antibody composition using these cells.

公开(公告)号：EP1308509A4

公开(公告)日：2004-05-12

申请号：EP01955553

申请日：2001-08-01

申请人： KYOWA HAKKO KOGYO KK

发明人： SATOH MITSUO ,  SHIBATA KENJI ,  SEKINE SUSUMU ,  KOIKE MASAMICHI ,  SAKURAI WATARU ,  FURUYA AKIKO ,  MORI KATSUHIRO ,  KATO YOKO

IPC分类号： A61K38/00 ,  A61K48/00 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/06 ,  A61P13/12 ,  A61P17/06 ,  A61P19/02 ,  A61P25/02 ,  A61P27/06 ,  A61P27/14 ,  A61P27/16 ,  A61P35/00 ,  A61P37/06 ,  A61P37/08 ,  C07K14/47 ,  C07K14/52 ,  C12P21/08 ,  C12N15/09 ,  A61K39/00

CPC分类号： C07K14/52 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47

摘要： A physiologically active peptide which is useful in searching for and developing remedies for diseases accompanying infection or inflammation, diseases accompanying abnormal differentiation and proliferation of smooth muscle cells, diseases accompanying abnormal activation of fibroblasts, diseases accompanying abnormal activation of synovial tissues, diseases accompanying disorders in pancreatic ss cells, diseases accompanying disorders in osteoblasts or osteoclasts, diseases accompanying abnormal activation of immunocytes, diseases accompanying vascular disorders, eye diseases based on abnormal angiogenesis, diseases accompanying abnormal cell proliferation, diseases in association with the major histocompatible antigen gene domain, etc.; DNA encoding this peptide; an antibody recognizing this peptide; and methods of using the same.

公开(公告)号：EP1676860A4

公开(公告)日：2008-12-31

申请号：EP04773775

申请日：2004-10-08

申请人： KYOWA HAKKO KOGYO KK

发明人： YAMADA TSUYOSHI ,  SATOH MITSUO ,  KANDA YUTAKA ,  YAMANO KAZUYA

IPC分类号： C07K14/47 ,  A61K38/57 ,  A61P7/02 ,  C07K14/81 ,  C12N1/19 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02

CPC分类号： C12P21/02 ,  C07K14/8128 ,  C12N9/1051 ,  C12N9/88 ,  C12N9/90 ,  C12Y204/01068 ,  C12Y402/01047 ,  C12Y501/03018

摘要： It is intended to provide a process for producing an antithrombin III composition comprising a genetically modified antithrombin III molecule having an N-glycoside-binding complex sugar chain, which has an N-glycoside-binding complex sugar chain having no fucose attached to N-acetylglucosamine at the reducing end of the sugar chain.

摘要翻译： 本发明提供一种抗凝血酶III组合物的制备方法，其包含具有复合型N-糖苷连接的糖链的抗凝血酶III分子，其中复合型N-糖苷连接的糖链具有岩藻糖不与N结合的结构 乙酰葡糖胺在糖链的还原端。

公开(公告)号：EP1676910A4

公开(公告)日：2007-03-14

申请号：EP04773769

申请日：2004-10-08

申请人： KYOWA HAKKO KOGYO KK

发明人： SATOH MITSUO ,  IIDA SHIGERU ,  MORI KATSUHIRO ,  INOUE MIHO ,  KAMOCHI REIKO ,  YAMANO KAZUYA

IPC分类号： C12N5/10 ,  A01H5/00 ,  A01K67/027 ,  A61K39/395 ,  C07K16/00 ,  C12N9/88 ,  C12N15/13 ,  C12P21/08

CPC分类号： C12N9/88 ,  A01K2217/075 ,  C07K16/00 ,  C07K2317/41 ,  C07K2317/732 ,  C12N2510/02

摘要： It is intended to provide a cell capable of regulating the sugar chain structure of a glycoprotein which is a protein product thereof, namely, a cell carrying a knockout genome gene of an enzyme which catalyzes a dehydration reaction of converting GDP-mannose into GDP-4-keto,6-deoxy-GDP mannose; a process for producing a glycoprotein by using the cell; a glycoprotein produced by this process; and its use.

公开(公告)号：EP1498490A4

公开(公告)日：2006-11-29

申请号：EP03723096

申请日：2003-04-09

申请人： KYOWA HAKKO KOGYO KK

发明人： SATOH MITSUO ,  KAMACHI REIKO ,  KANDA YUTAKA ,  MORI KATSUHIRO ,  YAMANO KAZUYA ,  KINOSHITA SATOKO ,  IIDA SHIGERU

IPC分类号： A61K39/395 ,  A61P9/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P35/00 ,  A61P37/02 ,  A61P37/04 ,  A61P37/08 ,  A61P43/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C12N9/10 ,  C12N15/113 ,  C12P21/08 ,  C12N15/11

CPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/2866 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732 ,  C12N9/1051 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/53 ,  C12Y204/01068

摘要： A process for producing an antibody composition with the use of cells characterized by using cells tolerant to a lectin recognizing a sugar chain structure in which an α-bond is formed between the 6-position of N-acetylglucosamine at the reducing end of an N-glycoside bond-type complex sugar chain and the 1-position of fucose; and cell usable in this process.

公开(公告)号：EP1686173A4

公开(公告)日：2006-11-22

申请号：EP04773766

申请日：2004-10-08

申请人： KYOWA HAKKO KOGYO KK

发明人： NAKANO RYOSUKE ,  SATOH MITSUO ,  IIDA SHIGERU ,  INOUE MIHO ,  KUSUNOKI MACHI ,  KINOSHITA SATOKO ,  OHNUKI NAOKO

IPC分类号： C12N5/10 ,  C12N5/00 ,  C12N15/13 ,  C12P21/08

CPC分类号： C12N5/0018 ,  C12N2500/92 ,  C12N2500/95 ,  C12N2510/00 ,  C12N2510/02

摘要： Attempts have been made to develop host cells capable of producing glycoprotein compositions such as antibody compositions useful in drug discovery. It is intended to provide a cell having been neutralized to a serum-free medium and carrying a knockout genome gene of an enzyme which participates in a sugar chain modification whereby fucose is attached via an alpha-bond at the 1-position to the 6-position of N-acetylglucosamine at the reducing end of an N-glycoside-binding complex sugar chain; and a process for producing a glycoprotein composition with the use of this cell.