发明公开
- 专利标题： SUBSTITUIERTE PHENYLALANIN-DERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON THROMBOTISCHEN / THROMBOEMBOLISCHEN ERKRANKUNGEN
- 专利标题（英）： Substituted phenylalanine derivatives and use thereof to treat thrombotic/thromboembolic diseases
- 专利标题（中）： 取代的苯丙氨酸衍生物及其血栓/血栓栓塞性疾病的治疗
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申请号： EP14771915.7申请日： 2014-09-24
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公开(公告)号： EP3049406A1公开(公告)日： 2016-08-03
- 发明人: RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： BIP Patents
- 优先权： EP13186057 20130926
- 国际公布： WO2015044170 20150402
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D231/56 ; C07D401/12 ; C07D235/26 ; C07D413/12 ; C07D249/10 ; C07D257/04 ; C07D271/07 ; A61K31/41 ; A61K31/416 ; A61K31/4184 ; A61K31/4196 ; A61K31/4245 ; A61K31/454 ; A61K31/496
摘要：
The invention relates to substituted phenylalanine derivatives of formula (I), in which R
1 stands for a group of formula (II) or formula (III), R
2 stands for hydrogen, fluorine, chlorine, methyl, or methoxy, R
3 stands for hydrogen, fluorine, chlorine, C
1 -C
4 alkyl, methoxy, or trifluoromethyl, and R
4 stands for amino, cyano, C
1 -C
3 alkoxy, C
1 -C
3 alkylamino, C
1 -C
3 alkoxycarbonyl, C
1 -C
3 alkylcarbonylamino, C
1 -C
3 alkysulfonyl, -S(O)
2 NR
10 R
11 , or 5- to 7-membered heterocyclyl bonded by means of a nitrogen atom. The invention further relates to the use thereof to produce drugs for treating and/or preventing illnesses, in particular cardiovascular diseases and/or perioperative heavy blood loss.
1 stands for a group of formula (II) or formula (III), R
2 stands for hydrogen, fluorine, chlorine, methyl, or methoxy, R
3 stands for hydrogen, fluorine, chlorine, C
1 -C
4 alkyl, methoxy, or trifluoromethyl, and R
4 stands for amino, cyano, C
1 -C
3 alkoxy, C
1 -C
3 alkylamino, C
1 -C
3 alkoxycarbonyl, C
1 -C
3 alkylcarbonylamino, C
1 -C
3 alkysulfonyl, -S(O)
2 NR
10 R
11 , or 5- to 7-membered heterocyclyl bonded by means of a nitrogen atom. The invention further relates to the use thereof to produce drugs for treating and/or preventing illnesses, in particular cardiovascular diseases and/or perioperative heavy blood loss.
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