- 专利标题: SHIP1 modulators and methods related thereto
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申请号: US14772737申请日: 2014-02-27
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公开(公告)号: US10100056B2公开(公告)日: 2018-10-16
- 发明人: Lloyd F. Mackenzie , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew
- 申请人: Aquinox Pharmaceuticals (Canada) Inc.
- 申请人地址: CA Vancouver
- 专利权人: Aquinox Pharmaceuticals (Canada) Inc.
- 当前专利权人: Aquinox Pharmaceuticals (Canada) Inc.
- 当前专利权人地址: CA Vancouver
- 代理机构: Seed IP Law Group LLP
- 国际申请: PCT/US2014/019125 WO 20140227
- 国际公布: WO2014/143561 WO 20140918
- 主分类号: C07D473/34
- IPC分类号: C07D473/34 ; C07D207/335 ; C07D207/06 ; C07D213/38 ; C07D231/12 ; C07D249/08 ; C07D233/60 ; C07D209/08 ; C07D317/46 ; C07D295/096 ; C07D213/64 ; C07D239/34 ; C07D241/18 ; C07C279/08 ; C07C215/42 ; C07C233/23 ; C07C311/04 ; C07C225/10 ; C07C233/74 ; C07C255/31 ; C07C275/24
摘要:
Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
公开/授权文献
- US20170253596A2 SHIP1 MODULATORS AND METHODS RELATED THERETO 公开/授权日:2017-09-07