A shopping facility assistance system includes a plurality of motorized transport units, a plurality of user interface units, and a central computer system having a network interface such that the central computer system wirelessly communicates with one or both of the motorized transport units and the user interface units. The central computer system is configured to control movement of the motorized transport units through a shopping facility space based at least on inputs from the user interface units. More particularly, the central computer system controls movement of the motorized transport units such that a given one of the plurality of motorized transport units selectively leads a user to a destination within the shopping facility or follows the user within the shopping facility as determined by the central computer system. By one approach, the motorized transport units move through the shopping facility via a plurality of preferred pre-determined path segments.