Invention Grant
- Patent Title: Azolylacryloyl derivatives as therapeutic agents for sickle cell disease
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Application No.: US15764052Application Date: 2016-09-30
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Publication No.: US10344001B2Publication Date: 2019-07-09
- Inventor: Martin K. Safo , Yan Zhang , Mohini Ghatge , Osheiza Abdulmalik , Abdelsattar Mansour Ebid Omar , Moustafa El-Sayed El-Araby
- Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
- Applicant Address: US VA Richmond SA Jeddah US PA Philadelphia
- Assignee: VIRGINIA COMMONWEALTH UNIVERSITY,KING ABDULAZIZ UNIVERSITY,THE CHILDREN'S HOSPITAL OF PHILADELPHIA
- Current Assignee: VIRGINIA COMMONWEALTH UNIVERSITY,KING ABDULAZIZ UNIVERSITY,THE CHILDREN'S HOSPITAL OF PHILADELPHIA
- Current Assignee Address: US VA Richmond SA Jeddah US PA Philadelphia
- Agency: W&C IP
- International Application: PCT/US2016/054684 WO 20160930
- International Announcement: WO2017/059204 WO 20170406
- Main IPC: A61K31/4174
- IPC: A61K31/4174 ; A61K31/4178 ; C07D233/58 ; A61P7/00 ; C07D405/12 ; C07D233/64
Abstract:
Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.
Public/Granted literature
- US20180282287A1 AZOLYLACRYLOYL DERIVATIVES AS THERAPEUTIC AGENTS FOR SICKLE CELL DISEASE Public/Granted day:2018-10-04
Information query
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