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公开(公告)号：US11104632B1
公开(公告)日：2021-08-31
申请号：US16872466
申请日：2020-05-12
IPC: C07C47/58 , C07C49/84 , A61P7/00 , C07C69/738 , C07C233/11 , C07D309/12
Abstract: Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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公开(公告)号：US11319292B2
公开(公告)日：2022-05-03
申请号：US17468035
申请日：2021-09-07
IPC: A61P7/00 , A61K31/34 , C07D233/64 , C07D307/46
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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Patent Agency Ranking
公开(公告)号：US20210340109A1
公开(公告)日：2021-11-04
申请号：US17064998
申请日：2020-10-07
IPC: C07D233/64 , A61P7/00 , C07D307/46
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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公开(公告)号：US20210403434A1
公开(公告)日：2021-12-30
申请号：US17468035
申请日：2021-09-07
IPC: C07D233/64 , A61P7/00 , C07D307/46
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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公开(公告)号：US10344001B2
公开(公告)日：2019-07-09
申请号：US15764052
申请日：2016-09-30
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Martin K. Safo , Yan Zhang , Mohini Ghatge , Osheiza Abdulmalik , Abdelsattar Mansour Ebid Omar , Moustafa El-Sayed El-Araby
IPC: A61K31/4174 , A61K31/4178 , C07D233/58 , A61P7/00 , C07D405/12 , C07D233/64
Abstract: Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.
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公开(公告)号：US11149012B1
公开(公告)日：2021-10-19
申请号：US17064998
申请日：2020-10-07
IPC: C07D233/64 , C07D307/46 , A61P7/00 , A61K31/34
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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公开(公告)号：US20180282287A1
公开(公告)日：2018-10-04
申请号：US15764052
申请日：2016-09-30
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Martin K. Safo , Yan Zhang , Mohini Ghatge , Osheiza Abdulmalik , Abdelsattar Mansour Ebid Omar , Moustafa El-Sayed El-Araby
IPC: C07D233/58 , C07D405/12 , A61P7/00
CPC classification number: C07D233/58 , A61K31/4174 , A61K31/4178 , A61P7/00 , C07D233/64 , C07D405/12
Abstract: Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.
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