公开(公告)号：US10344001B2

公开(公告)日：2019-07-09

申请号：US15764052

申请日：2016-09-30

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. Safo ,  Yan Zhang ,  Mohini Ghatge ,  Osheiza Abdulmalik ,  Abdelsattar Mansour Ebid Omar ,  Moustafa El-Sayed El-Araby

IPC: A61K31/4174 ,  A61K31/4178 ,  C07D233/58 ,  A61P7/00 ,  C07D405/12 ,  C07D233/64

Abstract: Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.

公开(公告)号：US09765017B2

公开(公告)日：2017-09-19

申请号：US15107962

申请日：2014-12-22

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. Safo ,  Richmond Danso-Danquah ,  Mohini Ghatge ,  Jurgen Venitz ,  Martin Mangino ,  Kevin R. Ward

IPC: C07C235/38 ,  A61K31/655 ,  C07C245/24 ,  A61K31/216 ,  A61K31/40 ,  A61K33/00 ,  A61K45/06

CPC classification number: C07C235/38 ,  A61K31/216 ,  A61K31/40 ,  A61K31/655 ,  A61K33/00 ,  A61K45/06 ,  C07C245/24 ,  Y02A50/411 ,  A61K2300/00

Abstract: Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.

公开(公告)号：US20180282287A1

公开(公告)日：2018-10-04

申请号：US15764052

申请日：2016-09-30

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. Safo ,  Yan Zhang ,  Mohini Ghatge ,  Osheiza Abdulmalik ,  Abdelsattar Mansour Ebid Omar ,  Moustafa El-Sayed El-Araby

IPC: C07D233/58 ,  C07D405/12 ,  A61P7/00

CPC classification number: C07D233/58 ,  A61K31/4174 ,  A61K31/4178 ,  A61P7/00 ,  C07D233/64 ,  C07D405/12

Abstract: Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.