公开(公告)号：US10344001B2

公开(公告)日：2019-07-09

申请号：US15764052

申请日：2016-09-30

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. Safo ,  Yan Zhang ,  Mohini Ghatge ,  Osheiza Abdulmalik ,  Abdelsattar Mansour Ebid Omar ,  Moustafa El-Sayed El-Araby

IPC: A61K31/4174 ,  A61K31/4178 ,  C07D233/58 ,  A61P7/00 ,  C07D405/12 ,  C07D233/64

Abstract: Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.

公开(公告)号：US20180282287A1

公开(公告)日：2018-10-04

申请号：US15764052

申请日：2016-09-30

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. Safo ,  Yan Zhang ,  Mohini Ghatge ,  Osheiza Abdulmalik ,  Abdelsattar Mansour Ebid Omar ,  Moustafa El-Sayed El-Araby

IPC: C07D233/58 ,  C07D405/12 ,  A61P7/00

CPC classification number: C07D233/58 ,  A61K31/4174 ,  A61K31/4178 ,  A61P7/00 ,  C07D233/64 ,  C07D405/12

Abstract: Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.