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1.发明授权公开(公告)号：US11458144B1
公开(公告)日：2022-10-04
申请号：US17560795
申请日：2021-12-23
Applicant: King Abdulaziz University , The Children's Hospital of Philadelphia , Virginia Commonwealth University
Inventor： Moustafa E. El-Araby , Abdelsatter M. Omar , Osheiza Abdulmalik , Martin K. Safo
IPC: A61K31/5377 , A61K31/341 , A61K31/4155 , A61P7/06 , A61K31/496 , A61K31/351 , A61K31/4525
Abstract: Methods for administering compounds provide a rapid treatment for sickle cell disease (SCD) to inhibit or reverse red blood cell sickling. The compounds are a group of 5-hydroxymethylfurfural (5-HMF) analogs modified to increase water-solubility. The compounds can be formulated in an aqueous carrier and administered intravenously for immediate uptake into red blood cells (RBCs) within hours, rather than days or weeks. In vitro experiments demonstrated rapid uptake into RBCs and increased O2 affinity of HbS to an equilibrium point within 30 to 90 minutes. The compounds have a desired level of safety as well as a short half-life, both of which are compatible with acute usage. Thus, the methods of treatment rapidly achieve therapeutic steady-state drug levels, making it possible to deliver a treatment in critical emergency care situations to prevent, reverse and otherwise treat acute sickling or anemia.
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公开(公告)号：US11104632B1
公开(公告)日：2021-08-31
申请号：US16872466
申请日：2020-05-12
IPC: C07C47/58 , C07C49/84 , A61P7/00 , C07C69/738 , C07C233/11 , C07D309/12
Abstract: Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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公开(公告)号：US11149012B1
公开(公告)日：2021-10-19
申请号：US17064998
申请日：2020-10-07
IPC: C07D233/64 , C07D307/46 , A61P7/00 , A61K31/34
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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公开(公告)号：US20180282287A1
公开(公告)日：2018-10-04
申请号：US15764052
申请日：2016-09-30
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Martin K. Safo , Yan Zhang , Mohini Ghatge , Osheiza Abdulmalik , Abdelsattar Mansour Ebid Omar , Moustafa El-Sayed El-Araby
IPC: C07D233/58 , C07D405/12 , A61P7/00
CPC classification number: C07D233/58 , A61K31/4174 , A61K31/4178 , A61P7/00 , C07D233/64 , C07D405/12
Abstract: Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.
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公开(公告)号：US11319292B2
公开(公告)日：2022-05-03
申请号：US17468035
申请日：2021-09-07
IPC: A61P7/00 , A61K31/34 , C07D233/64 , C07D307/46
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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Patent Agency Ranking
公开(公告)号：US10653634B1
公开(公告)日：2020-05-19
申请号：US16719248
申请日：2019-12-18
Inventor： Khalid M. El-Say , Osama A. A. Ahmed , Amir I. Mohamed , Abdelsattar M. Omar , Martin K. Safo
IPC: A61K9/51 , A61K31/138 , A61P15/12 , A61K9/19
Abstract: Dapoxetine nanoparticles comprising zein and alpha lipoic acid (ALA) are provided. When present in zein-ALA loaded nanoparticles, dapoxetine exhibits increased bioavailability (compared to conventional formulations) when administered to subjects for the prevention or treatment of premature ejaculation (PE). Thus, lower doses are administered, and side effects are attenuated or eliminated.
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公开(公告)号：US20210340109A1
公开(公告)日：2021-11-04
申请号：US17064998
申请日：2020-10-07
IPC: C07D233/64 , A61P7/00 , C07D307/46
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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公开(公告)号：US09765017B2
公开(公告)日：2017-09-19
申请号：US15107962
申请日：2014-12-22
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Martin K. Safo , Richmond Danso-Danquah , Mohini Ghatge , Jurgen Venitz , Martin Mangino , Kevin R. Ward
IPC: C07C235/38 , A61K31/655 , C07C245/24 , A61K31/216 , A61K31/40 , A61K33/00 , A61K45/06
CPC classification number: C07C235/38 , A61K31/216 , A61K31/40 , A61K31/655 , A61K33/00 , A61K45/06 , C07C245/24 , Y02A50/411 , A61K2300/00
Abstract: Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.
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公开(公告)号：US20210403434A1
公开(公告)日：2021-12-30
申请号：US17468035
申请日：2021-09-07
IPC: C07D233/64 , A61P7/00 , C07D307/46
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
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公开(公告)号：US10709662B1
公开(公告)日：2020-07-14
申请号：US16775304
申请日：2020-01-29
Inventor： Tarek A. Ahmed , Alaa O. Bawazir , Abdelsattar M. Omar , Martin K. Safo
Abstract: Mucoadhesive buccal films comprising a statin-hydroxypropyl-beta-cyclodextrin inclusion complex and a statin-loaded mixed micelle composition, wherein the ratio of the mixed micelle composition to the inclusion complex is from 2:0.5 to 2:1.5 are provided. Methods of improving permeation of a statin across mucosal tissue by administering the film to a subject are also provided.
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