Invention Grant
- Patent Title: Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
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Application No.: US15430218Application Date: 2017-02-10
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Publication No.: US10415059B2Publication Date: 2019-09-17
- Inventor: J. Keith Joung , Jeffry D. Sander , Morgan Maeder , Yanfang Fu
- Applicant: The General Hospital Corporation
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N9/10 ; C12N9/16 ; C12N9/22 ; C12N9/96 ; C12N15/01 ; C12N15/10 ; C12N15/11 ; C12N15/63 ; C12N15/85 ; C12N15/90 ; C07K14/005 ; C07K14/195
Abstract:
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
Public/Granted literature
- US20170152508A1 Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing Public/Granted day:2017-06-01
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