Invention Grant
- Patent Title: Method for determining the state of a cell
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Application No.: US15560694Application Date: 2016-03-23
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Publication No.: US10481076B2Publication Date: 2019-11-19
- Inventor: Cedric Allier , Geoffrey Esteban , Lionel Herve
- Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , IPRASENSE SAS , HORIBA ABX SAS
- Applicant Address: FR Paris FR Clapiers FR Montpellier
- Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES,IPRASENSE SAS,HORIBA ABX SAS
- Current Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES,IPRASENSE SAS,HORIBA ABX SAS
- Current Assignee Address: FR Paris FR Clapiers FR Montpellier
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: FR1552445 20150324
- International Application: PCT/FR2016/050644 WO 20160323
- International Announcement: WO2016/151249 WO 20160929
- Main IPC: G01N15/14
- IPC: G01N15/14 ; C12M1/34 ; G01N21/45 ; G01N21/47 ; G01N21/51 ; G03H1/08 ; G06K9/00 ; G06T7/00 ; G03H1/04 ; G01N33/483 ; G01N15/10 ; G01N21/17 ; G03H1/00 ; G01N15/00

Abstract:
A method for identifying a state of a cell contained in a sample, including: illuminating the sample using a light source by producing an incident light wave propagating toward the sample; then acquiring, using a matrix-array photodetector, an image of the sample, the sample being placed between the light source and the matrix-array photodetector such that the matrix-array photodetector is exposed to a light wave resulting from interference between the incident light wave and a diffraction wave produced by each cell; applying a numerical reconstruction algorithm to the image acquired by the matrix-array photodetector, to estimate a characteristic quantity of the light wave reaching the matrix-array detector, at a plurality of distances from the matrix-array photodetector. The value of the characteristic quantity, or its variation as a function of distance, allows the state of the cell to be determined from among predetermined states.
Public/Granted literature
- US20180113064A1 METHOD FOR DETERMINING THE STATE OF A CELL Public/Granted day:2018-04-26
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