- 专利标题： Delivery of therapeutic agents by a collagen binding protein
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申请号： US16283468申请日： 2019-02-22
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公开(公告)号： US11279922B2公开(公告)日： 2022-03-22
- 发明人: Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
- 申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
- 申请人地址： US AR Little Rock; JP Tokyo; US NY New York; JP Kagawa
- 专利权人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS,The Kitasato Institute,MONTEFIORE MEDICAL CENTER,NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
- 当前专利权人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS,The Kitasato Institute,MONTEFIORE MEDICAL CENTER,NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
- 当前专利权人地址： US AR Little Rock; JP Tokyo; US NY New York; JP Kagawa
- 代理机构： Quarles & Brady LLP
- 主分类号： A61K38/29
- IPC分类号： A61K38/29 ; A61K38/17 ; A61K38/18 ; A61K38/19 ; A61K39/395 ; C12N9/52 ; A61K8/49 ; A61K8/65 ; A61Q7/00 ; A61K47/64 ; A61K8/64 ; A61K8/66 ; A61K38/30 ; A61K39/44 ; A61Q7/02 ; A61K38/27 ; C07K14/475 ; C07K14/485 ; C07K14/49 ; C07K14/495 ; C07K14/50 ; C07K14/51 ; C07K14/535 ; C07K14/61 ; C07K14/71 ; C07K16/18 ; A61K39/00 ; A61K38/00
摘要：
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.