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公开(公告)号:US20220306722A1
公开(公告)日:2022-09-29
申请号:US17633173
申请日:2020-08-04
申请人: Icahn School of Medicine at Mount Sinai , Montefiore Medical Center , Albert Einstein College of Medicine, Inc.
发明人: Yaron Tomer , Roman Osman , Angela Lombardi
摘要: The disclosure provides polypeptides that specifically bind to HLA-DQ8 for treating Type 1 Diabetes (TID) and methods using same for reducing autoimmune destruction of pancreatic islet beta cells. In particular, the present disclosure relates to peptides containing at least one D-amino acid that are capable of blocking the presentation of antigenic islet peptides (e.g., lnsB:9-23) by HLA-DQ8, and to their uses, especially as it relates to the prevention and/or treatment of TID.
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公开(公告)号:US20210077832A1
公开(公告)日:2021-03-18
申请号:US16961436
申请日:2019-01-25
发明人: Tibor KELER , Michael YELLIN , Chandan GUHA , Nitin OHRI
摘要: Methods of treating cancer comprising administering to patients a dendritic cell mobilizing agent (e.g., Flt3 ligand) in combination with radiation and/or immunoregulatory agents (e.g., checkpoint inhibitors), are disclosed.
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公开(公告)号:US20190249163A1
公开(公告)日:2019-08-15
申请号:US16283468
申请日:2019-02-22
申请人: The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人: Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号: C12N9/52 , A61K47/64 , A61K38/29 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K14/50 , A61K8/49 , A61K8/65 , A61Q7/00 , A61K8/99 , A61Q7/02 , A61K8/64 , A61K38/18 , A61K38/27 , A61K39/395 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/51 , A61K8/66 , A61K38/17 , A61K38/19 , A61K38/30 , A61K39/44
CPC分类号: C12N9/52 , A61K8/4913 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/99 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/27 , A61K38/29 , A61K38/30 , A61K39/3955 , A61K39/44 , A61K47/64 , A61K2039/505 , A61K2039/6031 , A61K2800/57 , A61Q7/00 , A61Q7/02 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12Y304/24003
摘要: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号:US20180169037A1
公开(公告)日:2018-06-21
申请号:US15735214
申请日:2016-06-27
IPC分类号: A61K31/12 , A61P39/06 , A61K31/167 , A61K31/5375 , A61K31/381 , A61K31/495 , A61K31/402 , C07C49/825 , C07C49/84 , C07C49/80 , C07C49/807 , C07C233/33 , C07C323/22 , C07D295/112 , C07D333/22 , C07D207/04 , C07D207/325 , A01N1/02
CPC分类号: A61K31/12 , A01N1/0226 , A61K31/05 , A61K31/095 , A61K31/167 , A61K31/36 , A61K31/381 , A61K31/402 , A61K31/495 , A61K31/5375 , A61P39/06 , C07C49/80 , C07C49/807 , C07C49/825 , C07C49/84 , C07C233/33 , C07C323/22 , C07D207/04 , C07D207/325 , C07D295/112 , C07D333/22 , A61K2300/00
摘要: Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.
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公开(公告)号:US20170106093A1
公开(公告)日:2017-04-20
申请号:US15386626
申请日:2016-12-21
申请人: The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER
发明人: Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure
CPC分类号: A61K38/48 , A61K38/29 , A61K47/56 , A61K47/64 , C12Y304/00
摘要: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号:US09579273B2
公开(公告)日:2017-02-28
申请号:US14365226
申请日:2012-12-14
申请人: The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人: Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号: A61K8/65 , A61K8/99 , A61K38/29 , C07K14/635 , A61Q7/00 , A61K8/66 , A61K47/48 , A61K8/49 , A61K8/64 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/30 , A61K39/44 , A61Q7/02 , A61K39/00
CPC分类号: C12N9/52 , A61K8/4913 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/99 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/27 , A61K38/29 , A61K38/30 , A61K39/3955 , A61K39/44 , A61K47/64 , A61K2039/505 , A61K2039/6031 , A61K2800/57 , A61Q7/00 , A61Q7/02 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12Y304/24003
摘要: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
摘要翻译: 提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。 在这些方法中,治疗剂不是PTH / PTHrP受体激动剂或拮抗剂,碱性成纤维细胞生长因子(bFGF)或表皮生长因子(EGF)。 细菌胶原结合多肽片段将药物递送到部分未扭曲或扭曲不足的胶原蛋白部位。 还提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗胶原病的方法。 此外,提供使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。 最后,提供通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。
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公开(公告)号:US20150038423A1
公开(公告)日:2015-02-05
申请号:US14378067
申请日:2013-02-11
申请人: The Board of Trustees of the University of Arkansas , The Kitasato Institute , Montefiore Medical Center
发明人: Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure
CPC分类号: A61K38/48 , A61K38/29 , A61K47/56 , A61K47/64 , C12Y304/00
摘要: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
摘要翻译: 提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。 提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。 此外,提供了通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。
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公开(公告)号:US11413255B2
公开(公告)日:2022-08-16
申请号:US15735214
申请日:2016-06-27
IPC分类号: A61K31/167 , A61K31/191 , A61K31/122 , A61K31/12 , C07C49/825 , C07C49/82 , C07C49/835 , C07C49/78 , C07C233/33 , C07C323/22 , A61K31/495 , A61K31/05 , A61K31/095 , A61K31/36 , A61P39/06 , A01N1/02 , A61K31/381 , A61K31/402 , A61K31/5375 , C07C49/80 , C07C49/807 , C07C49/84 , C07D207/04 , C07D207/325 , C07D295/112 , C07D333/22
摘要: Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.
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公开(公告)号:US20210283370A1
公开(公告)日:2021-09-16
申请号:US16482724
申请日:2018-01-22
发明人: Lee Goddard , Madhur Garg , Wolfgang Tomé , Carlo Greco
摘要: A sterilizable device comprising electromagnetic transponders separated from one another by a flexible spacer material enclosed within radiofrequency-transparent sterilizable tubing for target tracking during prostate treatments, and method of use thereof.
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公开(公告)号:US20210205322A1
公开(公告)日:2021-07-08
申请号:US17144715
申请日:2021-01-08
发明人: Haiying Cheng , Roman Perez-Soler , Balazs Halmos , Ni Fan , Yiyu Zou
IPC分类号: A61K31/5377 , A61P35/00 , A61P35/04 , A61K31/519 , A61K31/426 , A61K31/517 , A61K31/506 , A61K31/53 , A61K31/4545 , A61K31/47 , A61K31/4745 , A61K31/4985 , A61K31/496 , A61K31/437
摘要: A method of treating metastases (e.g., brain metastases) in a patient with cancer (e.g., lung cancer) and at risk for metastases, exhibiting symptoms of metastases, or identified with metastases includes administering a therapeutically effective amount of a RICTOR inhibitor for the treatment of metastases. A method of reducing resistance to an EGFR, MET or AKT inhibitor in a cancer patient being administered the EGFR. MET or AKT inhibitor comprises co-administering a therapeutically effective amount of a RICTOR inhibitor and the EGFR, MET or AKT inhibitor. RICTOR inhibitors include compounds of formulas I-IV.
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