Invention Grant
- Patent Title: RNA-guided human genome engineering
-
Application No.: US16397423Application Date: 2019-04-29
-
Publication No.: US11359211B2Publication Date: 2022-06-14
- Inventor: George M. Church , Prashant G. Mali , Luhan Yang
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Banner & Witcoff, Ltd.
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/85 ; C12N15/10 ; C12N15/63 ; C12N15/90 ; C12N15/01 ; C12N15/81 ; C12N15/82 ; C12N15/87 ; C12N9/22
Abstract:
A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.
Public/Granted literature
- US20190249194A1 RNA-Guided Human Genome Engineering Public/Granted day:2019-08-15
Information query
IPC分类:
