Invention Grant
- Patent Title: Sorting of T lymphocytes in a microfluidic device
-
Application No.: US16253869Application Date: 2019-01-22
-
Publication No.: US11666912B2Publication Date: 2023-06-06
- Inventor: Kevin D. Loutherback , Yelena Bronevetsky , Peter J. Beemiller , Xiaohua Wang , Kevin T. Chapman
- Applicant: Berkeley Lights, Inc.
- Applicant Address: US CA Emeryville
- Assignee: Berkeley Lights, Inc.
- Current Assignee: Berkeley Lights, Inc.
- Current Assignee Address: US CA Emeryville
- Agency: Barnes & Thornburg LLP
- Agent Kenneth E. Horton
- Main IPC: B01L3/00
- IPC: B01L3/00 ; A61K35/17 ; G01N1/34 ; B03C5/02 ; A61K35/28 ; B03C5/00 ; G01N1/40

Abstract:
Methods of sorting T lymphocytes in a microfluidic device are provided. The methods can include flowing a fluid sample comprising T lymphocytes through a region of a microfluidic device that contains an array of posts. The array of posts can be configured to have a critical size (Dc) that separates activated T lymphocytes from naïve T lymphocytes. Also provided are microfluidic devices having an array of posts configured to separate activated T lymphocytes from naïve T lymphocytes, compositions enriched for T lymphocytes, particularly activated T lymphocytes that are known to be reactive to an antigen of interest, and methods of treating subjects suffering from a pathogenic disorder or cancer by administering such compositions.
Public/Granted literature
- US20190283026A1 Sorting of T Lymphocytes in a Microfluidic Device Public/Granted day:2019-09-19
Information query
IPC分类: