Invention Grant
- Patent Title: IKAROS zinc finger family degraders and uses thereof
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Application No.: US18297316Application Date: 2023-04-07
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Publication No.: US11897862B2Publication Date: 2024-02-13
- Inventor: Gayatri Balan , Peter A. Blomgren , Chen Chen , Julian A. Codelli , Zhimin Du , Musong Kim , Dorothée Saddier Axe , Gregg M. Schwarzwalder , Rhiannon Thomas-Tran , Michael T. Tudesco , Chandrasekar Venkataramani , William J. Watkins , Brian M. Weist , Suet C. Yeung , Helen Yu
- Applicant: Gilead Sciences, Inc.
- Applicant Address: US CA Foster City
- Assignee: Gilead Sciences, Inc.
- Current Assignee: Gilead Sciences, Inc.
- Current Assignee Address: US CA Foster City
- Main IPC: C07D401/04
- IPC: C07D401/04
Abstract:
The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
Public/Granted literature
- US20230295111A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF Public/Granted day:2023-09-21
Information query
