公开(公告)号：US20230295111A1

公开(公告)日：2023-09-21

申请号：US18297316

申请日：2023-04-07

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US20230373950A1

公开(公告)日：2023-11-23

申请号：US18184335

申请日：2023-03-15

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US11897862B2

公开(公告)日：2024-02-13

申请号：US18297316

申请日：2023-04-07

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05 ,  C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.