公开(公告)号：US20230295111A1

公开(公告)日：2023-09-21

申请号：US18297316

申请日：2023-04-07

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US11897862B2

公开(公告)日：2024-02-13

申请号：US18297316

申请日：2023-04-07

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05 ,  C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US12122764B2

公开(公告)日：2024-10-22

申请号：US18069028

申请日：2022-12-20

申请人： Gilead Sciences, Inc.

发明人： Peter A. Blomgren ,  Zhimin Du ,  Musong Kim ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani

IPC分类号： C07D401/14

CPC分类号： C07D401/14

摘要： The present disclosure relates to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2, including cancer.

公开(公告)号：US20230242508A1

公开(公告)日：2023-08-03

申请号：US18069028

申请日：2022-12-20

申请人： Gilead Sciences, Inc.

发明人： Peter A. Blomgren ,  Zhimin Du ,  Musong Kim ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani

IPC分类号： C07D401/14

CPC分类号： C07D401/14

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zink Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US20240124412A1

公开(公告)日：2024-04-18

申请号：US18068700

申请日：2022-12-20

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US20230373950A1

公开(公告)日：2023-11-23

申请号：US18184335

申请日：2023-03-15

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.